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《Journal of Environment and Health》 2008-08
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Effects of Benzimidazole on Spermatogenesis Function and Enzymatic Activity in Testis of Rats

YU Gong-chang WANG Xiao-fen LIU Yan-zhong,et al.Department of Toxicology,Shandong Academy of Occupational Health and Occupational Disease,Ji'nan,Shandong 250002,China  
Objective To explore the effects of benzirnidazole on spermatogenesis function and enzymatic activity in testis of male rats.Methods 40 male Wistar rats,clean degree,were randomly divided into four groups,10 in each.The rats in the low- dose group (20 mg/kg),the moderate-dose group (100 mg/kg) and the high-dose (200 mg/kg) were treated with benzimidazole at different doses by garage,once a day for 80 consecutive days.Simultaneously,the rats control group were treated with the equivalent volume of distilled water and tween-80.In the end of the experiment,the rats were weighed,the testis and epididymides were immediately excised and weighed,the appearance was observed,and the viscera coefficients of the bilateral testis and epididymides were calculated.The number and motility of sperms in the tail of epididymis,the activity of some enzymes (LDH, ACP,SDH,G-6-PDH) of testis were tested.Results The testis and epididymides in the control group and the low-dose group were pink,large,smooth and plump,but they were mauve,small,obviously atrophic in the moderate-dose group and the high-dose group. The viscera coefficient of the testis and epididymides,the number and motility of sperms in the tail of epididymis were significantly decreased in the moderate-dose group and the high-dose group (P0.01).The activity of ACP and SDH in the moderate-dose group and the high-dose group significantly decreased (P0.05,P0.01).The activity of LDH in the high-dose group significantly decreased (P 0.05).There is no significantly dedifference among the activity of G-6-PDH of four groups.Conclusion Benzimidazole can affect the spermatogenesis function of male rats by affecting the activity of energy metabolic enzymes in testicular tissue,leading to the sloughing of immature spermatogenic cells.
【Fund】: 山东省科技攻关计划项目(2006GG2202057)
【CateGory Index】: R114
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