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Antagonism of Dextromethorphan and Riluzole to Neurotoxicity Induced by Methylmercury in Rats

XIN Xin,XU Zhao-fa,DENG Xiao-qiang,et al.Department of Environmental Health,School of Public Health,China Medical University,Shenyang,Liaoning 110001,China  
Objective To observe the adverse effect of methylmercury on the cortex and cerebellum respectively as well as to approach the antagonisms of dextromethorphan(DM) and riluzole to the mercury-induced neurotoxicity.Methods Twenty-eight Wistar rats were randomly divided into 4 groups by weight,7 in each.The first group was the control group and the second group was methylmercuric chloride(MMC) group.The third and fourth groups were DM and riluzole group respectively.Both of the former groups were subcutaneously injected with saline.The third and fourth groups were subcutaneously injected with 13.5 μmol/kg DM and 21.35 μmol/kg respectively every other day.Two hours later,the animals in the control group were intraperitoneally given the injection of saline.From the second to fourth groups were injected with 12.0 μmol/kg MMC.The administration of MMC above was given five times a week(from Monday to Friday),for 4 weeks as well as the administration of DM and riluzole every other day before injected with MMC(on Monday,Wednesday and Friday).Twenty-four hours after the last injection,7 rats in each group were sacrificed.The contents of Hg,Ca2+-ATPase in the cerebellum were determined.Results In MMC group,the contents of Hg,Glu and the content of Gln were decreased,the activities of SDH,Na+-K+-ATPase and Ca2+-ATPase were decreased compared with the control group.Compared with MMC group,in DM and riluzole groups,the contents of Hg,Glu decreased,the content of Gln increased,moreover,the activities of SDH,Na+-K+-ATPase and glutamate(Glu),glutamine(Gln) in the rat cortex and the activities of SDH,Na+-K+-AT Pase and Ca2+-AT Pase increased significantly.Conclusion "Glu-Gln Cycle" can be destroyed by MMC,DM and liluzole present some antagonistic effects on MMC-indused neurotoxicity in rats.
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