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《Journal of Environment and Health》 2011-02
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Association between MT2A Gene Polymorphism and Water-Born Endemic Arsenism in Xinjiang

XIE Hui-fang,WU Shun-hua,ZHANG Jie,et al.College of Public Health of Xinjiang Medical University,Urumqi,Xinjiang 830011,China  
Objective To investigate the relationship between genetic polymorphism in MT2A rs10636 locus in chromosome 16 and susceptibility of water-born endemic arsenism.Methods MT2A gene polymorphism were analyzed by polymerase chain reaction restriction fragment length polymorphism technique(PCR-RFLP) among 96 patients with arsenism(case group),73 healthy individuals(intra-control,IC) and 89 unrelated healthy individuals(extra-control,EC) in 2007.Results The distributions of genotype frequencies of rs10636 were deviated from the Hardy-Weinberg equilibrium(P0.05);The difference of MT2A rs10636 CG,GG and CG genotype in three groups was statistically significant(χ2=16.353,P0.05).Binary logistic regression analysis showed: gender could effect MT2A genetic polymorphism(P0.05),the mutation superiority of female was higher than male by 1.941 times.Conclusions MT2A(rs10636) gene may be associated with water-born endemic arsenism,and can be used as a biomarker in the related study.
【Fund】: 国家自然科学基金(30960323)
【CateGory Index】: R599
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