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《Journal of Environment and Health》 2011-04
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Effect of Chlorpyrifos on Spermatogenesis Function and Enzymatic Activity in Male Rats

LIU Yan-zhong,LI Lan-bo,LI Xiang-xin Shandong Academy of Occupational Health and Occupational Medicine,Ji'nan,Shandong 250002,China  
Objective To explore the effects of chlorpyrifos on spermatogenesis function and enzymatic activity of male rats.Methods Forty male Wistar rats,clean degree,were randomly divided into four groups,ten in each.The rats in the low-dose group(2.7mg/kg),the moderate-dose group(5.4 mg/kg)and the high-dose group(12.8 mg/kg)were treated with chlorpyrifos through gavage,once a day for 90 consecutive days,and the volume of gavage was 10 ml/kg.The control rats were administered to the equal volume redistilled water and tween 80(solution concentration is 1 mg/L).In the end of the experiment,the number and motility of sperms in the tail of epididymis,the enzymatic activity were tested.Results The number and motility of sprems were significantly decreased in the moderate-dose group and the high-dose group(P0.05).The moderate and high-dose groups showed obvious histopathological abnormality of the testis.The activity of LDH increased in the rats exposed to 5.4 and 12.8 mg/kg groups(P0.05).Conclusion Chlorpyrifos can impact the spermatogenesis function of male rats.
【CateGory Index】: R114
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