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《Journal of Naval General Hospital of PLA》 2002-02
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Analysis on Treatment Results of 121 Patients with Primary Liver Carcinoma

JI Zhen hua, ZHANG Zhi cheng, BAI Gang, et al (Department of Hepatobiliary Surgery, Naval General Hospital, Beijing 100037, China)\;  
Objective To find the best protocol from analyzing therapeutic effect and significance of different methods for primary liver carcinoma.Methods 121 patients with primary liver carcinoma treated in 1991.5~1998.5 were divided into 4 groups: Conservative treatment group (A): only treated by oral chemotherapy, Chinese traditional medicine and hepatic function support; Chemoembolization group (B): taking 1~7 times hepatic arterial chemoembolization (HACE); Hepatic resection group (C): taking hepatic segmentectomy or lobectomy; Hepatic resection+chemotherapy group (D): taking HACE or portal vein infusion (PVI) or hepatic artery infusion (HAI) before or after hepatic segmentectomy or lobectomy. 57 patients treated by HACE were also divided into 4 groups: One time HACE (B 1); Two times HACE(B 2); Over three times HACE(B 3); HACE+other methods(B 4).Results The median survival period of 37 cases with early stage primary liver carcinoma was 24.0 months. Their survival rates in 1 ,2 and 3 year was 67.6%, 55.9%, 44.1% respectively. The median survival period of 87 cases with advanced primary liver carcinoma was 2.5, 8.0, 7.0 and 10.0 months in group A, B, C, D respectively. Their survival rates in 1 , 2 and 3 year was 8.3%, 0, 0 in group A; 28.1%, 10.5%, 7.0% in group B; 25.0%, 12.5%, 0 in group C; 50.0%, 10.0%, 10.0% in group D respectively. The survival rates differed significantly between 4 groups. Their survival rates in 1 , 2 and 3 year of 57cases treated by HACE was: 0, 0, 0 in group B 1; 37.5%, 12.5% 6.3% in group B 2; 35.5%, 11.8%, 5.9% in group B 3; 28.6%, 14.3%, 14.3% in group B 4 respectively. The survival rates differed significantly between B 1 and B 2, B 3, B 4. The survival rate in 3 year differed significantly between B 4 and B 1, B 2, B 3. Conclusion Surgical resection combined with local hepatic chemotherapy or chemoembolization significantly improves the curative effect and life quality of the patient with primary liver carcinoma. The best protocol of HACE is 2~3 times and with other adjuvant therapy.\;
【CateGory Index】: R735.7
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