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《Journal of East China University of Science and Technology(Natural Science Edition)》 2007-02
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Levofloxacin-Imprinted Membranes for Selective Separation of Ofloxacin under Solid Phase Extraction Conditions

BING Nai-ci,XU Zhen-liang,WANG Xue-jun,YANG Zuo-guo(Chemical Engineering Research Center,East China University of Science and Technology,Shanghai 200237,China)  
Using polyvinylidene foluoride hollow fiber ultrafiltration membrane as the supported membranes and the levofloxacin as the template,the molecularly imprinted membranes were prepared by thermal copolymerization.The interaction between the template and functional monomer is proved,and the binding constant is 3.83×10~5 L~2/mol~2 and chemical combination ratio is 2.The surface features of membranes were analyzed by scan electron micrographs.The solid phase extraction experiments show there are paths in the molecularly imprinted membranes which formed by the cavities with size and structure accommodated to levofloxacin and showed a better selectivity for it.Distributed coefficient K of the membranes to LVFX and OFLX could reach 2.7 and 2.This work increases the application of imprinted membrane(extraction) in chiral drug separation.
【Fund】: 国家重点基础研究发展计划(973计划)资助项目(2003CB615705)
【CateGory Index】: TQ028.8
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