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《Journal of East China University of Science and Technology(Natural Science Edition)》 2008-05
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A Novel Polyurethane Immobilized with Heparin

WANG Jun-bin,ZHAO Yan-chao,GONG Fei-rong,RAO Ju,CHENG Shu-jun(Key Laboratory for Ultrafine Materials of Ministry of Education,School of Materials Science and Engineering,East China University of Science and Technology,Shanghai 200237,China)  
Polyurethanes containing carboxyl group were synthesized by two-step solution polymeri-(zation.) Heparin was immobilized on the PU surface via reacting between carboxyl group and the amino group in the heparin by covalent immobilization technology in heparin sodium citrate buffer at 4 ℃.The(heparinized) polyurethanes were investigated by FT-IR,water contact angle and antithrombin tests.(Results)(show that) the highest heparin content of PU surface is in heparin sodium citrate buffer(pH=5.0) for 96 h.(The water) connect angle is reduced from 61° to 44° after heparinization.Meanwhile,heparinization(observably) improves the blood anticoagulation of polyurethane.
【Fund】: 上海市科委基金资助(05DJ14005)
【CateGory Index】: TQ323.8
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 LI Bao qiang, HU Qiao ling, FANG Zheng ping, XU Cheng wei (Instisute of Polymer Composites,Zhejiang University,Hangzhou 310027,China);Progress in Polyurethane for Tissue Engineering[J];Polymer Bulletin;2003-02
2 Hou Changjun 1,Zhang Wenbin 1,Huo Danqun 2,Chen Bingcan 2,Ren Yanyong 2,Zheng Shujia 2 (1 College of Chemistry and Engineering Chongqing University;2 Chongqing University Bioengineering College of National Opening and Tissue Engineering under the State Education Ministry,Chongqing 400044);Advances in the Study on Integrated Mode of Heparin and Noumenon Biomaterials[J];Chemical Industry and Engineering Progress;2003-07
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 NING Ren-de1,ZHOU Jian-sheng2(1.Department of Orthopedics,The First People′s Hospital of Hefei,Hefei Anhui 230031;2.Department of Orthopedics,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004,China);Preparation of acellular materials with adult rabbits′ peripheral nerve by improved freeze thaw[J];Journal of Bengbu Medical College;2009-04
2 YANG Huajuan Institute of Metal Research,Chinese Academy of Sciences,Shenyang 110016; Graduate School of Chinese Academy of Sciences,Beijng 100039 YANG Ke ZHANG Bingchun Institute of Metal Research,Chinese Academy of Sciences,Shenyang 110016;;Development and Prospect of Biomedical Stainless Steels[J];Materials Review;2005-06
3 XU Yizhan LIU Rongfang XIAO Xiufeng (College of Chemistry and Materials,Fujian Normal University,Fuzhou 350007);The Hydroxyapatite/Starch-based Composites[J];Materials Review;2005-09
4 HUANG Jingjing 1,2 ,YANG Ke1(1 Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016; 2 Graduate School of Chinese Academy of Sciences, Beijing 100049);Research on Magnesium Alloys for Bio-medical Applications[J];Materials Review;2006-04
5 LIAO Jianguo,LI Yubao,WANG Xuejiang,ZHANG Li,ZUO Yi,GONG Mei,CHENG Xianmiao (Research Center for Nano-Biomaterial,Analytical & Testing Center,Sichuan University,Chengdu 610064,China);Nano-hydroxyapatite/polycarbonate composites Ⅰ: Preparation and characterization[J];Acta Materiae Compositae Sinica;2008-03
6 LU Shen-zhou, LI Ming-zhong, HUANG Ling-ping, BAI Lun(Schoot of Material Engineering, Soochow University, Suzhou,Jiangsu 215021, China);Sediment and mineralization of calcium phosphate on the silk fiber[J];Journal of Textile Research;2006-11
7 GUANG Shan-yi,SHEN Yu-hua,DAI Chen-wei,ZHANG Jin,XU Hong-yao(1.School of Chemistry and Chemical Engineering,Anhui University,Hefei 230039, China;2.College of Chemistry and Chemical Engineering & College of Material Science and Engineering,Donghua University,Shanghai 201620,China);Research Progress of Hydroxyapatite/Polymer Composite Biomaterials[J];Polymer Materials Science & Engineering;2008-11
8 XIE Xiao-rui,ZHANG Li-ming,YI Ju-zhen (Institute of Polymer Science,School of Chemistry and Chemical Engineering,Sun Yat-Sen University,Guangzhou 510275,China);The Advance of Biodegradable Polymer Drug Film[J];Chinese Polymer Bulletin;2006-12
9 HAN Jin,LI Yu-bao,YAN Yong-gang,ZUO Yi,WANG Xue-jiang (The Research Center for Nano n-Biomaterials, and Analytical Test Center, Sichuan University, Chengdu 610064, China);Study on preparation and properties of nano-HA/PA66/HDPE biocomposite[J];Journal of Functional Materials;2005-01
10 HAN Ji-mei~(1,2),LI Yu-bao~1,MO Li-rong~1,WANG Xue-jiang~1,XU Feng-lan~1,WU Xi~1,WU Lan~1 (1.Research Center for Nano-Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu 610064 China; 2.College of Materials Science and Engineering, Sichuan University, Chengdu 610064 China);Study on the interfacial interaction between γ-(trimethoxysilyl) propyl methacrylate and nano-apatite[J];Journal of Functional Materials;2005-04
【Co-references】
Chinese Journal Full-text Database 2 Hits
1 HU Jin-qing, LIN Dong, SHEN Jian-kang, WANG Yi. Department of Neurosurgery, Ruijin Hospital, Shanghai Jiaotong University, Shanghai 200025, China;Treatment of bilateral traumatic carotid cavernous fistulae with endovascular covered stent deployment[J];Chinese Journal of Neuromedicine;2006-01
2 Hou Changjun 1,Zhang Wenbin 1,Huo Danqun 2,Chen Bingcan 2,Ren Yanyong 2,Zheng Shujia 2 (1 College of Chemistry and Engineering Chongqing University;2 Chongqing University Bioengineering College of National Opening and Tissue Engineering under the State Education Ministry,Chongqing 400044);Advances in the Study on Integrated Mode of Heparin and Noumenon Biomaterials[J];Chemical Industry and Engineering Progress;2003-07
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 LIU Fang, WANG De yong, LI Jie hua, XIE Xing yi, HE Chang sheng, FAN Cui rong, ZHONG Yin ping (Depanment of Polymer Material Science and Engineering, Sichuan University, Chengdu 610065, China);CHARACTERISTICS, STRUCTURE AND PERFORMANCE OF POLYURETHANES FOR CATHETERS[J];Polymeric Materials Science & Cngineering;2002-01
2 Cai Kaiyong Lin Songbai Yao Kangde (Research Institute of Polymeric Materials,Tianjin University, Tianjin 300072, China);Advances in Research on Surface Engineering of Biomaterials for Tissue Engineering[J];Progress In Chemistry;2001-01
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