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《Journal of East China University of Science and Technology(Natural Science Edition)》 2009-04
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Relationship between LHβ,FSHβ Genes and Central Precocious Puberty in Chinese Girls Based on the Polymorphisms in the 5′-Flanking Regions

ZHAO Ying~1,ZHOU Yu-xun~2,LI Kai~2,XIAO Jun-hua~2(1.School of Bioengineering,East China University of Science and Technology,Shanghai 200237,China;2.Institute of Biology Science and Technology,Donghua University,Shanghai 201620,China)  
In this paper,four single nucleotide polymorphisms(LHβ-1424 C/G,LHβ-238 G/A,FSHβ-261 G/T,FSHβ-132 T/A) in the 5′ upstream regions of LHβ and FSHβ were found in 27 case samples by sequencing.And these four SNPs were genotyped in 283 chinese girls suffered central precocious puberty(CPP) and 284 normal girls.Results show that the association of four polymorphisms in the 5′ upstream regions of LHβ and FSHβ with CPP is not significant(P0.05).And there is no relationship between the CPP and the SNPs in the transcriptional regulation region of LHβ and FSHβ.
【Fund】: 国家自然科学基金(30771191);; 上海市科学基金(071409004)
【CateGory Index】: R725.8
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