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《JOURNAL OF EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY》 1997-05
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Screening of Streptomyces Spiramyceticus for Phage Resistant Strain

Ye Ruifang *, Zheng Li, Xie Zhimei, Yang Li and Tang Guangyan (Department of Biochemistry Engineering ECUST, Shanghai 200237)  
A high spiramycin yielding and phage resisting mutant was obtained by way of mutagenesis. The starting strain Streptomycin spiramyceticus PS was first treated with Co irradiation, the phage resisting mutant R10 isolated with a slightly higher yield. Then from strain R10 through rational screening, the strain T 8 was isolated on a plating medium, containing 2 deoxy glucose. T 8 has the stable phage resisting feature with a 20% increase in yield and 12h shortening in fermentation time when cultivated in shaking flask as compared with R10.
【CateGory Index】: TQ920
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1 Zhu Yibin;Laishen;Liu Xuewei;Caisen;Niu Jingang;Tianfang pharmaceutical co.,ltd;;Influence of Al~(3+) on Spiramycin Fermentation[J];当代化工研究;2017-05
2 Wu Pei;Zhang Xiaohong;Liu Shouqiang;Xie Ting;Sun Yujie;Northwest A&F University;Topfond Pharmaceutical Co.,Ltd.;;Influence of Zn~(2+) on Spiramycin Biosynthesis[J];山东化工;2017-11
3 ZHENG Yu-qing;School of Life Science and Biopharmaceutics,Shenyang Pharmaceutical University;;Regulation Techniques for Biosynthesis of Spiramycin in Molecular and Genetic Level Along with Ferment[J];生物技术通报;2016-08
4 LIU Shou-qiang;ZHAO Zhong;LIU Guo;ZHOU Shu-mei;LI Ai-ling;WANG Liu-guo;Topfond Pharmaceutical Co.,Ltd.;Department of Mathematical Sciences,Huanghuai University;Environmental Protection Bureau of Zhumadian;;Screening Spiramycin High-Producing Strain with UV and Heavy Metal Ion Resistance Mutation[J];化学与生物工程;2016-05
5 Zhang Zenghui;Yang Shushen;Liu Shouqiang;Wu Pei;Wang Jianguo;Northwest A&F University;Topfond Pharmaceutical Co.Ltd.;;A Study on the Influencing Factors of the Spiramycin Components and Mechanism Analysis[J];广东化工;2016-06
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