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《Journal of Harbin University of Commerce(Natural Sciences Edition)》 2007-04
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Relationship between DNA methylation aberration and human tumor

YANG Hong-dan,GAO Shi-yong(Cneter of Research and Development on Life Scineces and Environmental Sciences,Harbin University of Comerce,Harbin 150076,China)  
DNA methylation which is an enzyme-mediated chemical modification that adds a methyl(CH3) group at selecetd sites on DNA is the best understood mechanism in epigenetics.There are different degrees of DNA methylation aberration in human tumor cells.The role of DNA methylation in gene expression and its mechanism of inhibiting gene transcription and expression,especially CpG island of suppress gene and the relationship between methylation aberration of other related genes and the occurrence,advancement of tumor are introduced in this article.Meanwhile examination methods of methylation and the application prospect of demethylation in treating tumor are also mentioned in this article.
【Fund】: 国家自然科学基金项目(30400352);; 教育部重点项目(205045);; 黑龙江省自然科学基金(D200611);; 黑龙江省研究生创新基金(YJSCX2006-0077HSD)
【CateGory Index】: R730.2
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