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《Journal of Harbin University of Commerce(Natural Sciences Edition)》 2007-04
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Relationship between DNA methylation aberration and human tumor

YANG Hong-dan,GAO Shi-yong(Cneter of Research and Development on Life Scineces and Environmental Sciences,Harbin University of Comerce,Harbin 150076,China)  
DNA methylation which is an enzyme-mediated chemical modification that adds a methyl(CH3) group at selecetd sites on DNA is the best understood mechanism in epigenetics.There are different degrees of DNA methylation aberration in human tumor cells.The role of DNA methylation in gene expression and its mechanism of inhibiting gene transcription and expression,especially CpG island of suppress gene and the relationship between methylation aberration of other related genes and the occurrence,advancement of tumor are introduced in this article.Meanwhile examination methods of methylation and the application prospect of demethylation in treating tumor are also mentioned in this article.
【Fund】： 国家自然科学基金项目(30400352);; 教育部重点项目(205045);; 黑龙江省自然科学基金(D200611);; 黑龙江省研究生创新基金(YJSCX2006-0077HSD)
【CateGory Index】： R730.2
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【References】
Chinese Journal Full-text Database 1 Hits
1 GAO Shi-yong,ZOU Xiang,JI Chen-feng,WANG Hong-liang(Postdoctoral Research Station,Inistitute of Materia Medica,Life Science and Enviroment Science Research Center,Harbin Commerce University,Harbin 150076,China);Study of solanine on apoptosis in HepG_2 cell[J];Journal of Harbin University of Commerce(Natural Sciences Edition);2007-06
【Citations】
Chinese Journal Full-text Database 6 Hits
1 WU Jun, LIANG Biao, HE Jianyou, ZHANG HaiTao, WANG Zhigang. Institute of Respiration, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, P.R.China;Study on detection of aberrant promoter hypermethylation of p16 and DAP kinase in serum DNA from patients with non-small cell lung cancer[J];Chinese Journal of Lung Cancer;2002-03
2 ZHOU Cui-lan, YIN Yu-fang, ZHANG Jia,et al(Department of SNP,Nanhua University, Hengyang, Hunan 421001,China);Biological Implications of DNA Methylation and DNA Methylation Assays[J];Journal of Nanhua University(Medical Edition);2005-02
3 DONG Yu_wei,HOU Jin_hui,ZHU Bi_cai,PANG Yong_hong(School of life Science,Xuzhou Normal University,Xuzhou,221116,Jiangsu,China);Concepts related to epigenetics and their advances[J];Journal of Biology;2005-01
4 Yao Qunfeng,Ning Yong,Zhang Liping,et al Department of Laboratory Medicine,Hubei College of Traditional Chinese Medicine,WuHan 430064;Significance of Detection of p16 Gene Methylation and CYFRA21-1 in Serum for Diagnosis of Lung Cancer[J];Chinese Journal of Microcirculation;2006-01
5 ZHANG Yong-Biao, CHU Jia-You(Department of Genetics, Institute of Medical Biology, Peking Union Medical College, Kunming 650118, China);Progress of Research on Epigenetic and Human Disease[J];Hereditas(Beijing);2005-03
6 Guo Xiaoqing Wang Shijie Zhang Jianhui et al Department of Endoscopy, the Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang;CpG Island Methylation of p16 and FHIT Gene in Tissues of the Esophageal Precancerous Lesions[J];Chinese Journal of Clinical Oncology;2005-10
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 YANG Xia1,YANG Sheng-li1,LU Quan-jun2,YAN Ai-hua1(1.Department of Esophageal Cancer Research,The First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052,Henan;2.Department of Nutrition and Food Hygiene,College of Public Health,Zhengzhou University,Zhengzhou 450052,Henan,China);Analysis on the Methylation of the Promoter of MGMT Gene and p16 Gene in Esophageal Squamous Cell Carcinomma[J];Carcinogenesis,Teratogenesis & Mutagenesis;2008-04
2 ZHANG Li-Xia1, PAN Shi-Yang1, CHEN Dan1, XIE Er-Fu1, GAO Li1, SHU Yong-Qian2, LU Zu-Hong3, CHENG Lu3, YANG Di4, ZHANG Ji-Nan4 1. Center of Clinical Laboratory, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210029, P. R. China 2. Department of Oncology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210029, P. R. China 3. Department of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu, 210096, P. R. China 4. Department of Cardiovascular Disease, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, 210029, P. R. China;Effect of Adenomatous Polyposis Coli(APC) Promoter Methylation on Gene Transcription in Lung Cancer Cell Lines[J];Chinese Journal of Cancer;2007-06
3 TENG Li-Juan, LI KeDepartment of Molecular Epidemiology, Medical College, Shantou University, Shantou, Guangdong, 515041, P. R. China;Research Progress on the Relationship between Nutrition and Cancer Epigenetics——Histone Modification Mechanisms[J];Chinese Journal of Cancer;2007-09
4 ZHANG Wen, SUN Yu'e, LU Guangming. Department of Thoracic Surgery, PLA General Hospital, Beijing 100853, P.R.China;The diagnostic value of determination of p16 methylation of sputum exfoliated cells for peripheral lung cancer[J];Chinese Journal of Lung Cancer;2004-01
5 GUO Xiao-qing LI Zhao-shen. Department of Endoscopy,Hebei Affiliated Hospital,Hebei Medical University,Shijiazhuang(050011),Department of Gastroenterology,Changhai Hospital,Second Military Medical University,Shanghai(200433),China;DNA methylation and malignant tumor[J];International Journal of Digestive Diseases;2007-01
6 Zhang Yong,Qin Na,Cao Ji,et al.(Department of Radiotherapy,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021 China);PRELIMINARY STUDIES ON THE METHYLATION OF GENE RUNX3 IN NASOPHARYNGEAL CARCINOMA[J];Journal of Guangxi Medical University;2009-02
7 Hong-Li Li,1 Wei-Dong Zhang,2 Wen-Tong Li2 and Chong-Gao Yin31.Medicine Research Experiment Center of Science Research, Weifang Medical College, Weifang, Shandong, 261042, P.R.China 2.Department of Pathology, Weifang Medical College, Weifang, Shandong, 261042, P.R.China 3.Department of Nursing, Weifang Medical College, Weifang, Shandong, 261042, P.R.China;Effect of 5-Aza-dC on FHIT gene expression in hepatocellular carcinoma cell line HepG2[J];Chinese Journal of Cancer;2009-09
8 WU Chun-tai,LI Wei-guo,GAO Xin-sheng,ZHANG Xiao-fei(1.Rubber Research Institute,Chinese Academy of Tropical Agriculture Sciences,Danzhou,Hainan 571737;2.State Center for Rubber Breeding,Danzhou,Hainan 571737;3.Key Laboratory for Tropical Crops Physiology,Ministry of Agriculture,Danzhou,Hainan 571737,China);Methylation-sensitive Amplified Polymorphism and Its Application Prospect in Hereditary and Breeding of Rubber Trees[J];Guizhou Agricultural Sciences;2009-11
9 Wu Junye ,et al Harbin longwei medicine science and technology development Limited company;Molecular Mechanism Analysis of Etiology Pathogenesis and Guiding Radiation Therapy Significance of Nasopharyngeal Carcinoma RUNX3 Genemethylation Changes[J];Heilongjiang Medicine Journal;2009-03
10 WANG Zheng-chao,PAN Xiao-yan,PANG Xun-sheng (1.College of Animal Science and Technology,Nanjing Agricultural University, Nanjing 210095,China; 2.Anhui College of Science and Technology,Bengbu 233100,China);Dosage Compensation of Early Embryo and Its Effect on the Development of Mammals[J];Acta Ecologiae Animalis Domastici;2006-06
China Proceedings of conference Full-text Database 2 Hits
1 YANG Xia YAN Aihua DING Lanping GONG Yaou YANG Shengli (1.Department of Esophageal Cancer, College of Basic Medicine, Zhengzhou University, Zhengzhou Henan 450052 );Analysis on the Methylation of the Promoter of MGMT Gene and p16 Gene in Esophageal Squamous Cell Carcinomma[A];[C];2008
2 ;Research on Epigenetics and Human Diseases[A];[C];2008
【Co-references】
Chinese Journal Full-text Database 5 Hits
1 SHEN Zuo jun 1, SUN Zeng pei 2, YANG Shu de 3 (1.Anhui Provincial Hospital,Anhui Provincial Center for Clinical Laboratories, Hefei 230001, China; 2.National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050,Chin;A method of on-column sample stacking in capillary electrophoretic analysis of micro-scale amino acids[J];Chinese Journal of Biochemical Pharmaceutics;2001-02
2 Yong-hong ZHANG2, Hai-yan PENG3, Guo-hao XIA3, Ming-yan WANG3, Ying HAN4 First Clinical College; 3Basic Medicine College, Nanjing University of TraditionalChinese Medicine, Nanjing 210029; 4Jiangsu Institute of Materia Medica, Nanjing 210009, China;Anticancer effect of two diterpenoid compounds isolated from Annona glabra Linn[J];中国药理学报(英文版);2004-07
3 CAI Zhen, BAO Han-ying and LIN Mao-fangDepartment of Hematology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China;Correlation between survivin mRNA expression and homoharringtonine induced apoptosis of malignant hematopoietic cells[J];中华医学杂志(英文版);2005-07
4 DENG Dajun, DENG Guoren, L*B Youyong, et al. Beijing Institute for Cancer Research, School of Oncology, Peking University, Beijing 100034, China;Analysis of the methylation in CpG island by denaturing high-performance liquid chromatography[J];National Medical Journal of China;2001-03
5 Yang Guangwen,Zhang Shaoyun,Zhang Xiaojian, et al Shanxi Tumor Hospital(Taiyuan ,030013);THE EXPERIMENTAL STUDY ON TUMOR INHIBITION AND ACUTE TOXICITY TEST ABOUT LONGSHEN INJECTION[J];CANCER RESEARCH AND CLINIC;1999-02
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 GAO Shi-yong1,2,XU Li-li1,2,JI Yu-bin1,2(1.Postdoctoral Program of Insititute of Materia Medica,Center for Life Sciences and Environmental Sciences,Harbin University of Commerce,Harbin 150076,China;2.MOE Engineering Research Center of Natural Anticancer Drugs,Harbin University of Commerce,Harbin 150076,China);Induction of solanine on HepG2 cell apoptosis by regulation of Bcl-2/Bax expression and caspase-3 activity[J];Chinese Traditional and Herbal Drugs;2009-10
2 GAO Shi-yong~(1,2),XU Li-li~(1,2),JI Yu-bin~(1,2) (1.Postdoctoral Research Station,Institute of Materia Medica,Center for Life Sciences and Environmental Sciences, Harbin University of Commerce,Harbin 150076,China;2.MOE Engineering Research Center of Natural Anticancer Drugs,Ministry of Education,Harbin University of Commerce,Harbin 150076,China);Solanine on apoptosis by regulating glutathine hormone and reactive oxygen species to damage mitochondrial structure in HepG2 cell[J];Chinese Traditional and Herbal Drugs;2009-11
【Secondary Citations】
Chinese Journal Full-text Database 7 Hits
1 PAN Qiang-rong1*,ZHANG Xing1,XU Ze-feng1,ZHENG Shu21.Clinical Experimental Research C enter,The Second Affiliated Hospit al,School of Medicine,Zhejiang University,Hangzhou 310009,P.R.China2.Cancer Research Institute,Zheji ang University,Hangzhou 310009,P.;Significance of Combined Determination of CK19mRNA,Carcinoembryanic Antigen,Neuron-Specific Enolase,and Tissue Polypeptide Antigen in Peripheral Blood of Patients with Lung Cancer[J];Chinese Journal of Cancer;2002-02
2 Pan Huizhong 　Huang Peiqi 　Su BoShanghai First Pneumology Hospital, Shanghai, 200433　　;The significance of CYFRA211 in diagnosis,commenting therapeutic value and prognosis for pulmonary carcinoma[J];CHINESE JOURNAL OF CANCER;1998-01
3 Fang Jing-Yuan; Zhu Shun-Shi; Shi Yao;et al(Shanghai Second Medical University Shanghai lnstitute of Digestive Disease);ALTERATION OF DNA HYPOMETHYLATION AND HISTOPATHOLOGY IN GASTRIC CARCINOMAS[J];SHANGHAI MEDICAL JOURNAL;1996-01
4 LIU Hong lin(College of Animal Science and Technology,Nanjing Agricultural University,Nanjing 210095, China);Recent Advance in Genome "Imprint" in Mammalian[J];HEREDITAS(BEIJING);2000-04
5 Wang Guoli *,Du Chuanshu,Lin Qundi.*Department of Medical Genetics,Sun Yat sen University of Medical Sciences,Guangzhou,510089;p16 INK4/CDKN2 GENE DELETIONS AND MUTATIONS IN NON-SMALL CELL LUNG CANCERS[J];CHINESE JOURNAL OF MEDICAL GENETICS;1998-01
6 YAO Qun-feng, KANG Xin-jiang, NING Yong, TANG Zhao-hui,ZHOU Yi-kai. Institute of environment Medine, Tongji Medical College, HuaZhong University of Science & Technology,Wuhan 430030,china Corresponding author: ZHOU Yi-kai;Detection of p16 promoter hypermethylation by nested methylation specific polymerase chain reaction[J];Chinese Journal of Laboratory Medicine;2004-02
7 DENG Dajun, DENG Guoren, L*B Youyong, et al. Beijing Institute for Cancer Research, School of Oncology, Peking University, Beijing 100034, China;Analysis of the methylation in CpG island by denaturing high-performance liquid chromatography[J];National Medical Journal of China;2001-03
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