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《Heilongjiang Medical Journal》 2008-12
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Clinical Application of Tumor Marker CEA、CA125、NSE、CYFRA21-1 in Diagnosis of Lung Cancer

WANG Na (Department of Laboratory,Dagang Hospital of Tianjin,Tianjin 300270,China)  
Objective To study the clinical of serum CEA,CA125,NSE and CYFRA21-1 in the diagnosis of lung cancer.Methods Collect 40 health persons,56 patients of pulmonary benign lesion,92 patients of pulmonary carcinoma,and detect the contents of CEA,CA125,CYFRA21-1 and NSE in the serum by electrochemiluminescence immunoassay.Results The level of the four serum tumor markers in lung cancer patients was significantly higher than those in pulmonary benign lesion and health persons(P0.01).The level of CYFRA21-1 in patients with squamous-cell carcinoma was significantly higher than that in other subtypes.The level of CA125 and CEA in patients with glandular carcinoma was significantly higher than that in other subtypes.The level of NSE in patients with small-cell lung cancer was significantly higher than those in the other subtypes of lung cancer.The positive of combining test is 95.6%,that was obviously higher than only testing the single item.Conclusion The sensitivity and specificity of the four combined tumor markers was obviously higher than single tumor marker,there was price in the diagnosis of lung cancer.
【CateGory Index】: R734.2
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