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Experimental Study on the Traditional Chinese Drug R in the Prevention of NSAR-Induced Cancer of the Proventriculus in Mice

Yang Wenxian ,et al Henan Tumuitr Institute,Zhengzhou, 450003  
This paper reports the application of NSAR to the induction of squamous cell cancer of the proventriculus for the animal model of the NIH mice and the preventive effect of the traditional Chinese medicine R on blocking canceration as well as on the impact of the activities of the NK and SOD. The results showed that the Chinese drug R had an apparent effect on blocking canceration and demon strated an apparent relationship between dosage and effect. Of the several groups experimented on.ani mals weighing 4g in weight with a period of 42 days of preliminary drug administration showed a relatively good effect with an inhibition rate of 77. 77%(P0. 01). These findings suggest that the drug play its role chiefly during the initiation stage of carcinogenesis. It can also rise the activities of the NK and SOD and has the function of immunoconsolidation and detoxification,thus constituting a potential chemical for prevention, deserving further studies on its intervention experiments and on the mechanism of its function to be conducted for the humans.
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