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《Journal of Basic and Clinical Oncology》 2006-05
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Alteration of Telomere Length in the Gastric Carcinoma

Fang Jie~1,Liu Shuman~2,Wu Jinglan~2,Zhang Qinxian~2(1.Department of Internal Medrcine,Huaxian People's Hospital,Huaxian 456400,China;2.Department of Histology and Embryology,College of Medicine,Zhengzhou University,Zhengzhou 450052,China)  
Objective To evaluate the alteration of telomere length in gastric carcinoma.Methods Southern blot was used to detect the telomere length in gastric carcinoma,matched adjacent tumor tissue and normal gastric mucosa.Results In 32 samples,the telomere length in gastric carcinoma,matched adjacent tumor tissue and corresponding normal gastric mucosa were respectively 5.088±1.712kb,5.969±1.659kb and 6.728±(1.707)kb.There was no significant correlation between the telomere shortening in gastric carcinoma and the pathological grades,invasion depth,lymph node metastasis and tumor size.Conclusions Telomere length in gastric carcinoma shortened obviously than that in corresponding normal gastric mucosa and adjacent tumor tissue.Telomere shortening may not be used as a sensitive biomarker to judge the malignance of gastric carcinoma.
【CateGory Index】: R735.2
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