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《Journal of Basic and Clinical Oncology》 2007-01
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The Expression and Significance of MMP2,MMP9 and VEGF in Non-Small Cell Lung Carcinoma

Wu Suiqun~1,Zhao Wei~2(1.Department of Radiology,the People's Hospital of Weihui City,Weihui 453100,China;2.The Nursing College of Zhengzhou University,Zhengzhou 450052,China)  
Objective To study the expression and significance of MMP2,MMP9 and VEGF in non-small cell lung carcinoma. Methods MMP2,MMP9 and VEGF expressions were determined in surgically treated 77 cases with non-small cell lung carcinoma tissues and their adjacent tissues.Results The immunoreactivities of MMP2, MMP9 and VEGF were mainly shown in cytoplasma of tumor cells.The overexpressions of MMP2,MMP9 and VEGF in carcinoma tissues were significantly higher than those in adjacent tissues(P0.05).The overexpressions of MMP2 and VEGF in the cancer tissues were related to clinical stages,lymph node metastasis status and the size of primary cancer(P0.05).There was a trend that the survival rate of these patients with overexpression of MMP2 and MMP9,and VEGF was lower than that with non-overexpression,but there was no statistical significance.The survival rate of the group with both MMP2 and MMP9,and VEGF overexpressions was lower than that with non-overexpression(P0.05).Conclusions MMP2、MMP9 and VEGF all take part in the progress of non-small cell lung carcinoma.We postulate that MMP2 can cooperate with VEGF in the processes.To investigate the over-expressions of both MMP2 and MMP9 in non-small cell lung carcinoma tissues may be more helpful for estimating the prognosis.
【CateGory Index】: R734.2
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