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《Journal of Basic and Clinical Oncology》 2008-05
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An Experimental Study of Effect of SXG on IFN-γ、TXB_2 and 6-Keto-PGF1α of C_(57)BL/6 Mice with Lewis Lung Cancer

Pang Shuzhen,Wang Xu(Heze Medical College,Heze 274030,China)  
Objective To investigate the regulation of spleen IFN-γ,serum TXB2 and 6-Keto-PGF1α of C57BL/6 inbred mice implanted Lewis lung cancer,and to explain the anti-metastasis of the Shanxian granule(SXG).Methods 10 C57BL/6 mice were selected from the 40 mice at random as blank group(A group).The rest 30 mice were planted by Lewis lung cancer cells.And they were divided randomly into Lewis lung cancer control group(B group),JinLong capsule(JLC) group(C group), and SXG group(D group).After planted 24 hours,the mice of C-group were given JLC(50 mg/mL),the mice of D-group were given SXG(0.5 g/mL).The mice of A,B groups were given normal saline.And we observed the time of the tumor coming into being.The 21 days after making model,we killed the 40 mice,and measured the weight of the transplanted tumor and mice,etc.Results The time of the tumor coming into being of D-group mice were obviously longer than that of B-group(P0.01).And the weight of mice were higher than that of B-group(P0.01).The activity of D-group IFN-γ were higher than that of B-group.SXG can reduce the TXB2/6-Keto-PGF1α ratio.Conclusion SXG can inhibit the growth and metastasis of Lewis lung cancer and its possible mechanism is the enhancement of the activity of IFN-γ,and the reduction of the TXB2/6-Keto-PGF1α ratio.
【Key Words】： Shanxian Granule(SXG) metastasis IFN-γ TXB2 6-Keto-PGF1α
【CateGory Index】： R734.2
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