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《Journal of Basic and Clinical Oncology》 2011-06
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The Clinical Effect of FOLFOX4 Regimen in the Treatment of Patients with Advanced Hepatocellular Cancer

Tian Hao,Cheng Zhaohui,Zhang Ruigang,Zhuang Guangxia(Department of Oncology,the People's Hospital of Xinyi,Xinyi 221400,China)  
Objective To observe the clinical effect and toxicities of FOLFOX4 regimen in the treatment of patients with advanced hepatocellular cancer. Methods Seventeen patients with advanced hepatocellular cancer were treated with FOLFOX4 regimen:L-OHP 85 mg/m2,ivgtt,d1;CF 200 mg/m2,ivgtt,d1,2;5-Fu 400 mg/m2,ivgtt,d1,2;and 5-Fu 600 mg/m2,CIA,d1,2.Three weeks were one cycle,and the effect and toxicities were evaluated after 2 cycles of chemotherapy. Results Among the 17 cases,no case was in CR,1 case was in PR,12 cases were in SD,4 cases were in PD.The total response rate was 5.9%.The clinical benefit rate was 76.5%.The major toxicities were gastrointestinal reaction and peripheral nerve toxicity. Conclusion FOLFOX4 regimen is a feasible systemic chemotherapy regimen for patients with advanced hepatocellular cancer,and it is effect and safe.
【CateGory Index】: R735.7
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【Citations】
Chinese Journal Full-text Database 3 Hits
1 QIN Shu-kui, CAO Meng-ran, QIAN Jun, et al. PLA Cancer Center, the 81th Hospital, Nanjing 210002;Clinical study of FOLFOX regimen for the patients with advanced hepatocellular carcinoma[J];Chinese Clinical Oncology;2005-01
2 YANG Chao-xu,QIN Shu-kui.PLA Cancer Center,81st Hospital of PLA,Nanjing 210002,China;Clinical study progression of oxaliplatin for primary hepatic carcinoma[J];Chinese Clinical Oncology;2010-09
3 Chinese Societies of Liver Cancer and Clinical Oncology,Chinese Anti-Cancer Association;Liver Cancer Study Group,Chinese Society of Hepatology,Chinese Medical Association(YE Sheng-long and QIN Shu-kui);Expert consensus on standardization of the management of primary liver cancer[J];Tumor;2009-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 QIAN Hong1,2,JIN Yong1(1.Anhui Medical University,Hefei 230032;2.Anqing Naval Hospital,Anqing 246003);Clinical results of oxaliplatin-containing regimen for the patients with advanced hepatocellular carcinoma[J];Anhui Medical and Pharmaceutical Journal;2007-07
2 HUANG Hai-xin,ZHENG Zhi-yong,LI Gui-sheng(Department of oncology,the 4th affiliated hospital of Guangxi Medical University,Liuzhou 545005,China);Clinical study of double-way chemotherapy with gemcitabine and oxaliplatin in the treatment of advanced primary hepatocarcinoma[J];Chongqing Medicine;2007-22
3 Huang Guangsheng, Zeng Huilan, Jiang Jianwei, et al. Department of Biochemistry, Medical College, Jinan University, Guangzhou 510632;Chemosensitivity of hepatocellular carcinoma cells is enhanced by galactose receptor mediated PCNA antisense oligodeoxynucleotides[J];Guangdong Medical Journal;2005-04
4 QIAN Chenga,WU Wei-pinga,JI Cun-lia,CHENG Li-jiea,QIAN Yia,XU Hong-xiaa,DENG Zai-xingb(a.Department of Breast Surgery;b.Department of Pathology,Huzhou Women and Children Care Hospital,Huzhou,Zhejiang 313000,China);The Effects of Dose-dense Neoadjuvant Chemotherapy for the Apoptosis of Breast Cancer[J];Medical Journal of National Defending Forces in North China;2007-01
5 YAN Yu-xia1,JIANG Jian-wei1,CAO Ming-rong2,WU Zhi-hui1, LIN Chun-lan1,DING Wen-ting1,CHEN Miao-qiao1 (1.Department of Biochemistry,Medical College;2.The First Affiliated Hospital,Jinan University,Guangzhou 510632,China);Survivin antisense oligodeoxynucleotide mediated by polyethyleneimine enhances sensitivity to chemotherapy in SMMC-7721,a human hepatocelluar carcinoma cell line[J];Journal of Jinan University(Medicine Edition);2007-02
6 ZHAN Zheng-yua,ZHONG Lu-xingb,ZHANG Lingb,PENG Xiao-dongb,XIONG Jian-pingb(a.2005 Grade Department of Medical,Graduate School;b.Department of Oncology,the First Affiliated Hospital,Nanchang University,Nanchang 330006,China);Treatment of Hepatocellular Carcinoma with Oxaliplatin Combinated with Epirubicine Fluorouracil[J];Practical Clinical Medicine;2008-01
7 MA Ai-ying,CHEN Qing-feng. The Department of Oncology,The 455 Hospital of PLA,Shanghai 200052,China;Clinical observation of interventional chemotherapy with oxaliplatin combinated with chemotherapy treating hepatic carcinoma[J];Chinese Clinical Oncology;2005-04
8 QIAN Jun,QIN Shu-kui,YANG Ai-zhen,XU Hai-jun,HUA Hai-qing,LIU Shen-lin.First Medicine College to Nanjing Chinese Medicine University,Nanjing 210046,China;Experimental research about different inhibition of platinum complexes in human hepatocellular carcinoma cell line[J];Chinese Clinical Oncology;2009-05
9 HUA Hai-qing,JIANG Zi-yu,YANG Ai-zhen,QIN Shu-kui.Center of Oncology,Nanjing 81 Hospital of PLA,Nanjing 210002,China;The effect of Fufangkushen injection alone and the combined effect with oxaliplatin for antiproliferative and apoptotic action on human hepatoma cell line SMMC-7721[J];Chinese Clinical Oncology;2010-01
10 ZHANG Jun-kai,PAN Pei-ling,WU Ying-meng,XIAO Jian-jun,PENG Jie-wen.Department of Oncology,the Peoples' Hospital of Zhongshan City,Zhongshan 528403,China;Clinical observation of advanced primary hepatocarcinoma with FOLFOX6 regimen[J];Chinese Clinical Oncology;2010-01
China Proceedings of conference Full-text Database 1 Hits
1 ;The effection on angiogenesis of liver cancer when Xiaoaiping injection combined with Oxaliplatin[A];[C];2010
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 QIAN Hong1,2,JIN Yong1(1.Anhui Medical University,Hefei 230032;2.Anqing Naval Hospital,Anqing 246003);Clinical results of oxaliplatin-containing regimen for the patients with advanced hepatocellular carcinoma[J];Anhui Medical and Pharmaceutical Journal;2007-07
2 ZUO Guo-qing, ZHANG Yan, TANG Wei-xue (1.Department of Gastroenterology, the Second Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400010,China;2.Department of Pathophysiology, Chongqing University of Medical Sciences, Chongqing 400016,China);The expression of apoptosis-associated genes protein in human hepatoma cell lines treated with oxaliplatin[J];Chongqing Medical Journal;2005-01
3 LI Jian,WANG Hong-lin,CHENG Xiang,et al.(Department of General Surgery,the First Affiliated Hospital, Chongqing University of Medical Sciences,Chongqing 400010 China);Clinical results of oxaliplatin-containing regimen in the TACE of advanced hepatocellular carcinoma[J];Chongqing Medical Journal;2005-09
4 HUANG Hai-xin,ZHENG Zhi-yong,LI Gui-sheng(Department of oncology,the 4th affiliated hospital of Guangxi Medical University,Liuzhou 545005,China);Clinical study of double-way chemotherapy with gemcitabine and oxaliplatin in the treatment of advanced primary hepatocarcinoma[J];Chongqing Medicine;2007-22
5 HE Song 1, ZUO Guo-qing 1, ZHANG Yan 1, TANG Wei-xue 2 ( 1Department of Gastroenterology, The Second Affiliated Hospital, Chongqing 400010; 2Department of Pathophysiology, Chongqing University of Medical Sciences, Chongqing 400016, China);Mechanism of supression on proliferation of human hepatoma cell line QGY by oxaliplatin[J];Acta Academiae Medicinae Militaris Tertiae;2005-12
6 ZHAN Zheng-yua,ZHONG Lu-xingb,ZHANG Lingb,PENG Xiao-dongb,XIONG Jian-pingb(a.2005 Grade Department of Medical,Graduate School;b.Department of Oncology,the First Affiliated Hospital,Nanchang University,Nanchang 330006,China);Treatment of Hepatocellular Carcinoma with Oxaliplatin Combinated with Epirubicine Fluorouracil[J];Practical Clinical Medicine;2008-01
7 QIN Shu-kui, CAO Meng-ran, QIAN Jun, et al. PLA Cancer Center, the 81th Hospital, Nanjing 210002;Clinical study of FOLFOX regimen for the patients with advanced hepatocellular carcinoma[J];Chinese Clinical Oncology;2005-01
8 MA Ai-ying,CHEN Qing-feng. The Department of Oncology,The 455 Hospital of PLA,Shanghai 200052,China;Clinical observation of interventional chemotherapy with oxaliplatin combinated with chemotherapy treating hepatic carcinoma[J];Chinese Clinical Oncology;2005-04
9 QIAN Jun,QIN Shu-kui,YANG Ai-zhen,XU Hai-jun,HUA Hai-qing,LIU Shen-lin.First Medicine College to Nanjing Chinese Medicine University,Nanjing 210046,China;Experimental research about different inhibition of platinum complexes in human hepatocellular carcinoma cell line[J];Chinese Clinical Oncology;2009-05
10 HUA Hai-qing,JIANG Zi-yu,YANG Ai-zhen,QIN Shu-kui.Center of Oncology,Nanjing 81 Hospital of PLA,Nanjing 210002,China;The effect of Fufangkushen injection alone and the combined effect with oxaliplatin for antiproliferative and apoptotic action on human hepatoma cell line SMMC-7721[J];Chinese Clinical Oncology;2010-01
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