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《Heilongjiang Journal of Traditional Chinese Medicine》 2009-04
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Experimental Study on Analgesic Action and Dermal Acute Toxicity of Incompatible Medicaments(Wutoubanxiasan)

Gongke~1 Zhang shijun~(2Δ) He guangxing~3 Wangjia~3 Wei jianjun~4 Mao yi~1 Chen rong~1 1.Chengdu Hospital of Integrated Traditional and Western Medicine(Sichuan Chengdu 610017). 2.Institute of Acupuncture & Moxibustion and Meridians,Sichuan Academy of Chinese Medical Sciences(Sichuan Chengdu 610031) 3.Institute of Chinese Materia Medica,Sichuan Academy of Chinese Medical Sciences (Sichuan Chengdu 610041) 4.Institute of Blood Transfusion,Chinese Academy of Medical Sciences(Sichuan Chengdu 610081).  
Obective:to investigate analgesic actions,dermal acute toxicity,skin irritation and skin sensitization of Wutoubanxiasan.Methods:The animals were randomly assigned to treatment group which received Wutoubanxiasan and the control group which received the similar prescription free of Pinellia Ternate.The results were concluded from acetic acid writhing test on mice,skin absorption test on rabbits and kin sensitization test on Guinea pigs.Results:In acetic acid writhing test on mice, Wutoubanxiasan inhibited the writhing of mice,with statistically significant difference in comparison with that of the control group(P0.05).In skin absorption,test on rabbits,no obvious dermal acute toxicities were observed in the both groups Wutoubanxiasan caused no skin sensitization on Guineapigs,butthe control group caused mild skin sensitization on Guinea pigs.Conclusion: Wutoubanxiasan is provided with obvious analgesic action and free from dermal acute toxicity and skin sensitization,which suggests it can improve analgesic effect and suppresses dermal acute toxicities.
【Fund】: 四川省中医药管理局科研基金资助(编号:2003A02)
【CateGory Index】: R285.5
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【References】
Chinese Journal Full-text Database 2 Hits
1 XIA Xi-chao;YUAN Guo-qing;MA Yu-hong;Basic medical department,Nanyang Medical College;;Promoting-Role of Wu-Tou and Ban-Xia Mixture on Wound Healing of Rats[J];Journal of Chengdu University of Traditional Chinese Medicine;2015-02
2 XU Wan;ZHANG Jian-mei;ZHONG Gan-sheng;School of Basic Medical Sciences,Beijing University of Chinese Medicine;;Review on the experimental studies of suitable and contraindicant conditions of Chinese medicine antagonism compatibility aconitum and pinellia ternate[J];Global Traditional Chinese Medicine;2015-09
【Citations】
Chinese Journal Full-text Database 2 Hits
1 Zhao Alin Second People's Hospital of Yueqing,Zhejiang Province(325608);Chinese Drug Gubitong Treat Bone Arthrosis by External Application[J];Journal of Zhejiang University of Traditional Chinese Medicine;2007-01
2 HU Awei1 ZHANG Lei2 LU Jianfang3 ZHANG Gongli2 JIANG Congbin1 PENG Jusheng1 1Hubei Provincial Corps Hospital,Chinese People’ s Armed Police Forces,Wuhan 430061,China 2People's Hospital of Shiyan City 3WuHan Union Hospital of TongJi Medical College,HuaZhong University of Science and Technology.;Experimental Studies on Effect of FuFangJianGuGuanJieTang on Osteoarthritis in Rabbits[J];Chinese Journal of Traditional Medical Traumatology & Orthopedics;2007-02
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LU Jing-kun,CHEN Zhao-jun,WANG Yu-hua,XIAO Yun-feng,LI Wen-yan(Pharmacy Department,Inner Mongolia Medical College,Hohhot 010059,China);The Mutagenicity of Piperine[J];Carcinogenesis,Teratogenesis & Mutagenesis;2009-03
2 Ren Yanli et al.(College of Chemistry and Biological Science,Yili Normal University,Yining 835000,China);Study on Bacteriostasis Test of Xinjiang Wild Walnut Leave Extract[J];Anhui Agricultural Science Bulletin;2012-13
3 PEI Hai-long et al (Academy of Life Science,Northwest University,Xian,Shaanxi 710069 );Determination on Isopropyl Salicylate Anti-bacterial Activity in vitro[J];Journal of Anhui Agricultural Sciences;2008-34
4 FENG Yan-li et al (College of Veterinary Medicine,Gansu Agricultural University,Lanzhou,Gansu 730070);Study on the Pharmacodynamics and Acute Toxicity of Pyroline[J];Journal of Anhui Agricultural Sciences;2008-34
5 CHEN Xiao-ling et al(Academy of Life Science,Northwest University,Xian,Shaanxi 710069);Determination of Ethyl Salicylate Anti-bacterial Activity in vitro[J];Journal of Anhui Agricultural Sciences;2009-02
6 CAO Jie-wei(Shangqiu Center of Animal Disease Control,Shangqiu,Henan 476000);Pharmacological Test Study on Analgesic and Anti-inflammatory Effect of Gracilaria lemaneiformis[J];Journal of Anhui Agricultural Sciences;2009-16
7 HE Xiao-yan et al(Tonghua Teachers College,Tonghua,Jilin 134002);Experimental Research on the Antibechic and Expectorant Effects of Wild Ledum palustre Linn.var.dilatatum Wahlanberg from Changbai Mountain Areas[J];Journal of Anhui Agricultural Sciences;2010-01
8 HU Yi-bing et al(School of Bioengineering,Chengdu University,Chengdu,Sichuan 610106);Study on Sedative and Hypnotic Effects of Tartary Buckwheat Ethanol Extract[J];Journal of Anhui Agricultural Sciences;2010-05
9 LIU Yin-hua et al(Medical College of Shaoguan University,Shaoguan,Guangdong 512026);Effect of Xihuangcao and Huzhang on Gallbladder Movement and Tension of Biliary Duct Sphincter in Rabbits[J];Journal of Anhui Agricultural Sciences;2010-15
10 WEI Qin et al (Key Laboratory of Fermentation Resources and Application of Institutes of Higher Learning in Sichuan,Yibin University,Yibin,Sichuan 644000);Toxic Study on Compound "Keqingjia" Cream with Anti-Candida albicans[J];Journal of Anhui Agricultural Sciences;2010-33
China Proceedings of conference Full-text Database 10 Hits
1 MA Li-li~1,JIANG Zhuo-qin~2 (1.Guangdong Food and Drug Vocational College,Guangzhou 510520;2.Faculty of Nutrition,Public Health College of Sun Yat-Sen University,Guangzhou 510080);Research Progress of Health Effects and Application of Perilla frutescens[A];[C];2012
2 Teng hongli~(1,2) Yu shengmin ~1Mei Zhinan~3Wang yuanhua~1 1.Guangxi Institute of Minority Medicine/Traditional Zhuang Hospital of Guangxi Zhuang Autonomous Region,Nanning 530001 2.Hubei University Of Chinese Medicine,Wuhan,430065 3.South-Central University For Nationalities,Wuhan,430074;Pang barrels the safety of drug-bath experimental study of particle[A];[C];2010
3 ZHENG Meisheng, ZHU Lin, ZHENG Yunju (Wuhu Traditional Chinese Medical Hospital, Wuhu 241000,Anhui, China);Effects of Chinese Medicine Yu-Xia Capsule on Renovascular Hypertensive Rats Induced Hypotension[A];[C];2010
4 YANG Wei-li,ZENG Xiang-zhou,REN Shou-zhong,CHEN Feng ZHANG jun-qing,LIU Ming-sheng,(Faculty of Pharmacy,Hainan Medical College,Hainan Provincial Key Laboratory of R & D of Tropical Herbs,Hainan Haikou 571101,China);Pharmacodynamic of extract of Daphniphullum calucinum Benth and Polygonnm Hydropiper Linn[A];[C];2007
5 Yin-Feng Tan,Hai-Long Li,Jun-Qing Zhang,Nai-Guang Fu,Ming-Sheng Liu (Dpartment of Pharmacy,Hainan Medical College,Hainan Provincial Key Laboratory of R&D of Tropical Herbs,Haikou Key Laboratory of Medicine of national Li,Haikou 571101,China);Preliminary study on therapeutic basis of FengLiaoChangWeiKang in treatment of acute gastroenteritis[A];[C];2009
6 YANG Wei-Li,LAI Wei-Yong,ZHANG Jun-Qing (Hainan Medical College,Hainan Provincial Key Laboratory of R & D of Tropical Herbs Hainan Haikou 571101);Study on acute toxicity of different extractions of Nauclea offcinalis[A];[C];2009
7 WANG Vu-ying,HUANG Jiong,XIA Wen,LI Xing,WEI Ying,HE Na,SUN An-sheng,YU Li-mei;Effect of Yindan Xinnaotong capsulae molles on the Electrocardiogram Induced Acute Myocardium Ischemia by Pituitary in Rat[A];[C];2011
8 LI Guirong1, WANG Zhong2, WANG Wei3(1.Department of Pharmacy of the First Affiliated Hospital , 2. Pre-clinical Animal Trial Center, 3. Department of Pharmacy of the Fifth Affiliated Hospital, Xinjiang Medical University , Urumuqi 830054 , China);Experimental Study on Animal Acute Toxicity of Hypoglycemic Ziyabiti Tablet[A];[C];2009
9 XING Mao1 ,WANG Qin2 ,YI Mei-tong2 ,AO Li2(1.Dept of Pharmacy; Xinqiao Hospital; Third Military Medical University; Chongqing 400037,China; 2. Dept of Drug Research; Chongqing Hospital of Traditional Chinese Medicine; Chongqing 400020,China );Dose-Effect Relationship of Analgesic and Anti-inflammatory activities of Yugu Capsules[A];[C];2010
10 ;The effect of Mongolian medicine Xieriga-4 tablet on mouse pain induced by acetic acid and heat-stimulation[A];[C];2010
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Yu Shan,Qin Zhifeng,Shi Jun,et al Department of Chinese Medicine,Shanghai Changzheng Hospital,Shanghai(200003);Study on Analgesic Mechanism of Chinese Medicine[J];Journal of Zhejiang University of Traditional Chinese Medicine;2007-05
2 LOU Yu-qian(Henan Hospital of Rheumatism,Henan Rheumatism Research Institute,Zhengzhou 450045,China);The standardized research of nomenclature and classification of rheumatism[J];China Journal of Traditional Chinese Medicine and Pharmacy;2008-09
3 TONG Ji-ming,LI Lan-fang,SONG Li-ping,et al(Institute of Traditional Chinese Materia Medica of Chengde Medical College,Key Laboratory of Study and Exploiture for New Drugs of Traditional Chinese Medicine,Hebei Chengde 067000,China);STUDY ON THE ANALGESIC EFFECT OF WATER-SOLUBILITY EXTRACT OF THE FRUITS OF THLADIANTHA DUBIA[J];Journal of Chengde Medical College;2006-04
4 TONG Ji-ming,LI Lan-fang(Institute of Chinese Materia Medica,Chengde Medical college,Hebei Chengde 067000,China);ACUTE TOXICITY STUDY OF FRUIT OF THLADIANTHA DUBI BUNGE[J];Journal of Chengde Medical College;2010-03
5 ZHANG Gang,TAN Yin-hui,LU Lai-chun,et al.(1.Department of Stomatology;2.Department of Pharmacy,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China);Preparation of bFGF-PLA sustained release nanospheres and release characteristics in vitro[J];Chongqing Medicine;2006-11
6 Cao Bo1,Li Zhi1,Li Shaotang2,Deng Wenling1 (1.Department of Anus & Intestine The First Affiliated Hospital of Guiyang College of Traditional chinese Medicine/ Guizhou Provinal Anorectal Hospital,Guiyang,Guizhou 550001,China;2.Department of Anus & Intestine Shanghai Jiaotong University Affiliated Hospital,Xinhua Hospital,Shanghai 200092,China);Influence of Qi Yu Ointment on the expression of EGF mRNA in Anal Fistula Wound Granulation Tissue[J];Chongqing Medicine;2011-27
7 Gong Zhenyu1,Tong Yalin1,Wan Youhua2,Yang Runsheng3,Su Xiaoling3(1.Department of Burn and Plastic Surgery;2.Department of Pathology;3.Laboratory Animal Center, the 181st Hospital of Chinese People′s Liberation Army,Guilin,Guangxi 541002,China);Effect of Kangfu cream on the scald wound healing of rats with diabetes mellitus[J];Chongqing Medicine;2012-07
8 BIAN Ya-li;FAN Xin-sheng;YU Jing-hua;LI Yun;JIANG Chen-xue;CHEN Fei;Nanjing University of Chinese Medicine;;Effects of Modified Jinshui Liujun Decoction on the airway inflammation and airway reactivity of the asthmatic mice[J];China Journal of Traditional Chinese Medicine and Pharmacy;2015-01
9 Li Xinli,Zhao Hua(Medical school of weinan vocational and technical college,Shanxi Weinan 714000);Compatibility of Radix Aconiti tuber of Pinellia counterproductive on material basis[J];Guiding Journal of Traditional Chinese Medicine and Pharmacy;2012-02
10 FU Yu,GAO Jian,ZHAO Yu,SUN Yan-fang,LIU Xiu-mei,DING Xiao-li(Heilongjiang Conter for Disease Control and Preuertion,Harbin 150030,China);Establishment of cotent of aconitine determination method[J];Chemical Engineer;2010-11
【Secondary References】
Chinese Journal Full-text Database 4 Hits
1 XIA Xi-chao;YUAN Guo-qing;MA Yu-hong;Basic medical department,Nanyang Medical College;;Promoting-Role of Wu-Tou and Ban-Xia Mixture on Wound Healing of Rats[J];Journal of Chengdu University of Traditional Chinese Medicine;2015-02
2 MAO Mao;SUN Yong-hao;Zibo Hospital of Traditional Chinese Medicine;;Clinical observation on combination of “Ai-tong-xiao” and three steps “Pain relieving” method for cancer pain[J];Shanghai Journal of Traditional Chinese Medicine;2013-12
3 MAO Mao;SUN Yong-hao;PENG Ying-ge;Zibo Municipal Hospital of Traditional Chinese Medicine;;Clinical research of external application of “Aitongxiao ” combined with thermal therapy in releasing moderate to severe pain due to cancer[J];Shanghai Journal of Traditional Chinese Medicine;2014-12
4 CHENG Jing-yan;YANG Jing-qi;HE Fang-ming;ZHANG Jing;Beijing Jishuitan Hospital;;A Study on Unreasonable Prescriptions in Outpatient Department in Our Hospital[J];Chinese Journal of Information on Traditional Chinese Medicine;2015-01
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Liu Shiqing, He Ling, Peng HaoDepartment of Orthopaedics, Renmin Hospital, Wuhan University, Wuhan 430060,China;Effect of Esculetin on Osteoarthritis in Rabbit[J];Journal of Hubei Medical University;2004-05
2 WT4”BX]LIU Rui bo 1, HU Lian jun 1, HAN Chun sheng 2, JIA Chun hua 3, ZHAO Yong 4, HU Lian zhan 5 [WT4”HX](1.Xianghe Traditional Chinese Medicine Hospital,Hebei Xianghe,[ST5,4”HZ] 065400, China) [WT4”HX](2.China Jap;Research the pathology of ARSD in treating experimental patella arthritis[J];HEBEI MEDICINE;2000-04
3 WANG Xiu hua,SU Zi bing,TIAN Wan bin (Department of orthopedics,The Affiliated Hospital of Liaoning College of TCM,Shenyang 110032,Liaoning,China);Influence on the Rabbit Knee Joint Cartilage with Denmark Injection[J];Liaoning Journal of Traditional Chinese Medicine;2003-10
4 Wu Tao, Gao Xiang,Wang Yongjun,Hu Zhijun, Si Qi, Qu Ji,Li Li,Yang Jianyin,Teng Songmao. Department of Orthopedics of Traditional Chinese Medicine,Huadong Hospital,Shanghai 200040,China;INFLUENCE OF YIQIHUAYULISHUIFANG ON PROSTAGLANDINS METABOLISM IN OSTEOARTHRITIS RABBITS[J];Gereatrics & Health Care;2004-01
5 Gao Xiang, Wu Tao, Wang Yongjun,Hu Zhijun, Shi Qi, Qu Jia, Li Li,Teng SongmaoDepartment of Orthopedics of Traditional Chinese Medicine,Huadong Hospital, Shanghai 200040, China;INFLUENCE OF HISTOMORPHOLOGY IN OSTEOARTHRITIS OF RABBIT KNEE JOINT WITH YIQIHUAYULISHUIFANG[J];Gereatrics & Health Care;2004-02
6 CHU Li-xi,ZHOU En-yuan,ZHAO Min-hui Yue Yang Chinese and Western Medicine Integration Hospital Affiliated to Shanghai University of Traditional Chinese Medicine;Experimental Study on Osteoarthritis Treated by“Arthritis No.1 Formula”[J];Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai;2001-01
7 Mei Zhang,Ping Li,Jian Wang,Zhi-Min Zhai,Department of Tranditional Chinese Med icine,Anhui Provincial Hospital,Hefei 230001,Anhui Province,ChinaZhao-Hui Chen,Department of Acupuncture and Moxibustion,Anhui Institute of Trad itional Chinese Medicine,Hefei 230001,Anhui Province,China;Effects of brucine on nitric oxide induced apoptosis in chondrocyte[J];Chinese Journal of Clinical Rehabilitation;2003-26
8 TANG Yong 1,JIANG Jie 1,ZHOU Yong-hong 1,SUN Li 1,ZAO Yong 1,CHENG Ji-chang 2 (1.Faculty of TCM of Medieal College of JI Nan University,Guang zhou Guangdong 510632; 2.Guang Zhou University of TCM,Guang zhou Guangdong 510405);Effect of guyanding Recipe on iNOS Expression in Articular Cartilage of Knee Osteoarthritic in Rabbits Model[J];Journal of Yunnan College of Chinese Medicine;2004-01
9 WAN Rong,YANG Qing ming,DENG Lian fu.Shanghai Institute of Traumatology and Orthopaedics.(Shanghai,200025);Experimental Studies on Therapeutic Effect of HeiHuDan on the Rabbit Models of OA[J];China Journal of Orthopaedics and Traumatology;2001-02
10 CAO Yue long,FENG Wei,LI Zong ju,et al.Shuguang Hospital(Shanghai,200021);RGF's selective inhibition of PGE_2 on different parts of osteoarthritis in rabbits[J];China Journal of Orthopaedics and Traumatology;2001-10
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