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《Heilongjiang Journal of Traditional Chinese Medicine》 2009-04
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Experimental Study on Analgesic Action and Dermal Acute Toxicity of Incompatible Medicaments(Wutoubanxiasan)

Gongke~1 Zhang shijun~(2Δ) He guangxing~3 Wangjia~3 Wei jianjun~4 Mao yi~1 Chen rong~1 1.Chengdu Hospital of Integrated Traditional and Western Medicine(Sichuan Chengdu 610017). 2.Institute of Acupuncture & Moxibustion and Meridians,Sichuan Academy of Chinese Medical Sciences(Sichuan Chengdu 610031) 3.Institute of Chinese Materia Medica,Sichuan Academy of Chinese Medical Sciences (Sichuan Chengdu 610041) 4.Institute of Blood Transfusion,Chinese Academy of Medical Sciences(Sichuan Chengdu 610081).  
Obective:to investigate analgesic actions,dermal acute toxicity,skin irritation and skin sensitization of Wutoubanxiasan.Methods:The animals were randomly assigned to treatment group which received Wutoubanxiasan and the control group which received the similar prescription free of Pinellia Ternate.The results were concluded from acetic acid writhing test on mice,skin absorption test on rabbits and kin sensitization test on Guinea pigs.Results:In acetic acid writhing test on mice, Wutoubanxiasan inhibited the writhing of mice,with statistically significant difference in comparison with that of the control group(P0.05).In skin absorption,test on rabbits,no obvious dermal acute toxicities were observed in the both groups Wutoubanxiasan caused no skin sensitization on Guineapigs,butthe control group caused mild skin sensitization on Guinea pigs.Conclusion: Wutoubanxiasan is provided with obvious analgesic action and free from dermal acute toxicity and skin sensitization,which suggests it can improve analgesic effect and suppresses dermal acute toxicities.
【Fund】: 四川省中医药管理局科研基金资助(编号:2003A02)
【CateGory Index】: R285.5
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