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《Journal of Hunan University(Natural Sciences)》 2013-03
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Rivalry Effect of E2 and Cd on Estrogenicity and Potential Mechanisms

ZHANG Guang-ming1,LANG Lang2,ZHANG Pan-yue3,4(1.School of Environment & Natural Resource,Renmin Univ of China,Beijing 100872,China;2.Research Center on Life Sciences and Environmental Sciences,Harbin Univ of Commerce,Harbin,Heilongjiang 150028,China; 3.Key Laboratory of Environmental Biology and Pollution Control of Ministry of Education,Hunan Univ,Changsha, Hunan 410082,China;4.College of Environmental Science and Engineering,Hunan Univ,Changsha,Hunan 410082,China)  
17-Estradiol(E2),a typical natural estrin,was chosen to study the mixed effect of Cd with natural estrins.The aim is to understand the impact of Cd on human health.Human breast cancer cell MCF-7 increase examination was used to examine the estrogenicity.The results showed that Cd had estrogencity,but E2 dramatically decreased its effect.Cell cycle analyses showed that Cd,E2,and their mixture all increased the ratio of cells in the DNA synthetic phase and therefore promoted cell proliferation.Cell proliferation pathway analyses showed that Cd,E2,and mixture significantly reduced the expression of ERα protein in the cell.The rivalry effect between E2 and Cd was mainly from the MAPK signal transduction pathway.E2 and Cd both promoted the expression of Ki67 protein and prolification-related protein,but the mixture significantly reduced the expression of Ki67.
【Fund】: 国家自然科学基金资助项目(51178047);; 芙蓉学者计划项目(湘教办通[2010]293-10)
【CateGory Index】: R114
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Chinese Journal Full-text Database 10 Hits
1 MIN Tao-ling et al (College of Life Sciences,Nanjing Teachers University,Nanjing,Jiangsu 210097);Isolation and Identification of a Serratia marcescens from photosynthetic bacteria[J];Journal of Anhui Agricultural Sciences;2006-22
2 SHANG Rui et al(Istitute of Tropical Bioscience and Biotechnology,CATAS,Haikou,Hainan 571101);Preliminary Study on Streptomyces sp.Strain BM10 of Agricultural Antibiotics[J];Journal of Anhui Agricultural Sciences;2008-23
3 HUI Ming et al(College of Biological Engineering,Henan University of Technology,Zhengzhou,Henan 450001);Advances in Application Research of Bacillus subtilis[J];Journal of Anhui Agricultural Sciences;2008-27
4 PEI Tao et al(Biological Science & Technology College,Shenyang Agricultural University,Shenyang,Liaoning 110161);Study on Property and Purification of Antagonistic Bacteria P72 against Wheat Scab[J];Journal of Anhui Agricultural Sciences;2009-06
5 ZHANG Tian-xiao et al(School of Medicine and Pharmacy,Ocean University of China,Qingdao,Shandong 266003);Study on Enzymatic Extraction process of Polysaccharide from GANODERMA and Its Oxidation Resistance[J];Journal of Anhui Agricultural Sciences;2011-08
6 XU Chen, WANG Yi-zhong, CUI Han-bing, GONG Ling-yu (College of life science,Wuhan University, Wuhan 430072, China);Properties of Amylase from Haloferax mediterranei R4[J];Amino Acids & Biotic Resources;2004-04
7 GONG Xia1,WANG Lan-fang2,LE Guo-wei3(1.Department of Food Science,Shanghai Business School,Shanghai 200235; 2.School of Medicine,Tongji University,Shanghai 200092;3.School of Food Science,Jiangnan University,Wuxi 214036,China);Effect of Antimicrobial Peptide MDL-2 from Musca domestica Larvae on Permeability and Metabolism of Bacteria[J];Amino Acids & Biotic Resources;2011-03
8 ZHAO Guang-ying, LIN Xiao-na, SHEN Ke-min,ZHAN Xue-jia, SHEN Yi-han (College Food Science and Biotechnology Engineering, Zhejiang Gongshang University, Food Safety Key Lab of Zhejiang Province, Hangzhou 310035,China);Recognition of Four Mold Species with Smart Tongue[J];Chinese Journal of Sensors and Actuators;2009-04
9 CHEN Ben-liang,ZHANG Qi-zhong(Institute of Hydrobiology,Jinan University,Engineering Research Center of Tropical and Subtropical Aquatic Ecological Engineering,Ministry of Education,Key Laboratory of Aquatic Eutrophication and Control of Harmful Algal Blooms of Guangdong Higher Education Institutes,Guangzhou 510632,China);Progress on Research of Saprolegnia and Saprolegniasis Treatment in Fish[J];Fisheries Science;2011-07
10 LU Gui-qian1,ZHANG Li-ping1,FU Ruo-wen2(1.Research Development Center,Guangzhou Liby Enterprise Group Co.,Ltd.,Guangzhou 510370,China;2.Materials Science Institute,School of Chemistry and Chemical Engineering,Sun Yat-sen University,Guangzhou 510275,China);Study of bactericidal activity of new quaternary ammonium salts[J];China Surfactant Detergent & Cosmetics;2009-01
China Proceedings of conference Full-text Database 2 Hits
1 Zhou Xiaping (East China University of Science and Technology,Shanghai,200237);Advances in the Drug Research of Humic acid[A];[C];2009
2 WANG Hui1,ZHOU Bi-jun1,2,ZHANG Shuang-xiang1,WEN Min1,2,WANG Kai-gong1,2,CHENG Zhen-tao1,2,LONG Chong-chong1,YIN Xin1,LUO Yi 1(1.College of Animal Science,Guizhou University,Guiyang 550025,China;2.Laboratory for Animal Disease of Guizhou,Guiyang 550025,China);Detection of Goat Infected Contagious Caprine Pleuropneumonia with Abortion[A];[C];2012
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Yue Shunlin (Shanghai Municipal Water Works Shinan Co.Ltd Shanghai 200002,China);Problems of Endocrine Disruptors in Water Supply of Our Country[J];Water Purification Technology;2006-03
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