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《Military Medical Journal of South China》 2002-01
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Pharmacokinetics of Synergistic Effect of Coadministration of Cyclosporin A with Berberine Hydrocholride in Renal Transplantation Recipients

LI Qing, WU Xiao - chun, XIN Hua - wen, et al. Department of Clinical Pharmacology, Wuhan General Hospital, Guangzhou Command, PLA, Wuhan 430070  
Objective To study the pharmacokinetics of cyclosporin A (CsA) with or without combination of berberine hy-drochloride (Ber) in renal transplantation recipients. Methods Our study included 6 patients treated with CsA at 6 mg·kg-1d-1 for two weeks within one month after the renal transplantation. CsA content in the blood was determined by fluorescence polarization im-munoassay before and after coadministration of Ber in the patients. Results The pharmacokinetic parameters of CsA before the coadministration of Ber were T11/2, (2.62 ±1.00)h; Tmax(0.93±0.47)h; Cmax(11.76.7±405.88)μg·L-1; Cmin,/173.95?8.71)μg·L-1; AUC, (5237.7±1776.5)μg-L-1·h-1; CL/F, (35±15) L·h-1. The pharmacokinetic parameters of CsA after the coadministration of Ber were T1/2, (5.33±2.60)h; Tmax, (2.26±1.15)h; Cmax, (919.17 ±330.87) μg·L-1; Cmin, (319.22±163.45) μg ·L-1; AUC, (9213.7± 3802.6) μg·h· L-1; CL/F, (22 ±13) L·h-1. Conclusion Ber could significandy elevate the blood concentration of CsA in the renal transplantation recipients. After the coadministration of Ber, Tmax, of CsA was delayed and CL/F was decreased while T1/2 as well as AUC was increased. Two drugs coadministration had no effects on liver and renal functions.
【CateGory Index】: R969
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