Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Military Medical Journal of South China》 2002-01
Add to Favorite Get Latest Update

Pharmacokinetics of Synergistic Effect of Coadministration of Cyclosporin A with Berberine Hydrocholride in Renal Transplantation Recipients

LI Qing, WU Xiao - chun, XIN Hua - wen, et al. Department of Clinical Pharmacology, Wuhan General Hospital, Guangzhou Command, PLA, Wuhan 430070  
Objective To study the pharmacokinetics of cyclosporin A (CsA) with or without combination of berberine hy-drochloride (Ber) in renal transplantation recipients. Methods Our study included 6 patients treated with CsA at 6 mg·kg-1d-1 for two weeks within one month after the renal transplantation. CsA content in the blood was determined by fluorescence polarization im-munoassay before and after coadministration of Ber in the patients. Results The pharmacokinetic parameters of CsA before the coadministration of Ber were T11/2, (2.62 ±1.00)h; Tmax(0.93±0.47)h; Cmax(11.76.7±405.88)μg·L-1; Cmin,/173.95?8.71)μg·L-1; AUC, (5237.7±1776.5)μg-L-1·h-1; CL/F, (35±15) L·h-1. The pharmacokinetic parameters of CsA after the coadministration of Ber were T1/2, (5.33±2.60)h; Tmax, (2.26±1.15)h; Cmax, (919.17 ±330.87) μg·L-1; Cmin, (319.22±163.45) μg ·L-1; AUC, (9213.7± 3802.6) μg·h· L-1; CL/F, (22 ±13) L·h-1. Conclusion Ber could significandy elevate the blood concentration of CsA in the renal transplantation recipients. After the coadministration of Ber, Tmax, of CsA was delayed and CL/F was decreased while T1/2 as well as AUC was increased. Two drugs coadministration had no effects on liver and renal functions.
【CateGory Index】: R969
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 1 Hits
1 XIONG Lei,XIN Hua-wen,WU Xiao-chun,et al.Department of Clinical Pharmacology,Wuhan General Hospital,Guangzhou Military Command,Wuhan Hubei 430070,China;Effect of Berberine Chloride on Absorption Rate of Cyclosporin A by Small Intestine in Rat[J];Military Medical Journal of South China;2008-03
Chinese Journal Full-text Database 3 Hits
1 LIQing , WU Xiao-CHun , XIN Hua-Wen, YU Ai-Rong, ZHONG Ming-Yuan, LENG Jing-Hua, JIANG ZHao-Jian, ZHU Ming, TANG Li-Gong, XIE Sen (Department of Clinical Pharmacology, Wuhan General Hospital, Guangzhou Military Command, Wuhan 430070);Clinical Study on Coadministration of Cyclosporin A and Berberin Hydrochloride in Renal Transplanted Recipients[J];The Chinese Journal of Clinical Pharmacology;2001-02
2 LI Qing, WU Xiaochun, XIN Huawen , et al. Department of clinical pharmacology, Wuhan General Hospital, Guangzhou, Military Command, Wuhan 430070;Clinical study on increased blood concentration of cyclosporin A by berberin hydrochloride in renal transplanted recipients[J];Military Medical Journal of South China;2001-01
3 TANG Ligong, XIE Sheng, PAN Tiejun, et al. Department of Urology, Wuhan General Hospital of PLA, Cuangzhou Command, Wuhan 430070, China;Effect of berberine on the blood concentration of cyclosporine A in the renal transplant recipients[J];Chineae Journal of Organ Transplantation;2001-02
Chinese Journal Full-text Database 10 Hits
2 REN Ping, HUANG Xi, ZHANg Li, et al (任平,等) Xijing Hospital, Fourth Military Medical University (Xi'an,710032,China);The Pharmacokinetics Characteristics of Glyeyrrhinic and its Mechanism in Rat Model of Spleen Deficiency Syndrome with Different Phase[J];JOURNAL OF CHENGDU UNVERSITY OF TARDITIONAL CHINESE MEDICINE;2000-02
3 REN Ping 1, JIAO Kai 2, LI Yue Cai 1, HUANG Xi 1,ZANG Yi Min 3, WANG Yao Min 3 1Department of Geriatrics, Xijing Hospital, Xi’an 710033, China, 2Department of Endocrinology,Tang Du Hospital, 3Department of Physiology, Faculty;Different effects of tetramethylpyrazine and/or ferulate on hemodynamics in anesthetized dogs[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;1999-09
4 GU Yi, WANG Sheng Chun, GAO Su Li, JIANG Yong Pei Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China;Relative bioavailability of Wuling capsule in rabbits[J];Journal of The Fourth Military Medical University;2001-05
5 DU Chuan-fu, YU Li-xin, YAO Bing (Department of kidney Transplantation, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China);Central nervous system toxicity induced by tacrolimus after renal transplantation[J];Journal of First Military Medical University;2001-04
6 Pang Zhigong, Wang Baoqi, Wang Congying ( Xi'an Medical University, Xi'an 710061)Huang Hong (Xi'an Pharmaceutical Factory);Distribution and Remainer of Tetrahydropalmatine in Rabbit Viscera[J];Chinese Journal of Analytieal Chemistry;1994-06
7 Cha Weixiong Hu Liege Leng Junfeng;A Mathmatical Analysis of Enzymatic Kinetic System and Algorithm of Nonlinear Least Squars[J];Systems Engineering;1996-01
8 CHEN Heng Wu * (Department of Chemistry, Xixi Campus, Zhejiang University, Hangzhou 310028, China) FANG Zhao Lun (Analytical Science Research Centre, Northeastern University, Shenyang 110006, China);Determination of Pseudoephedrine in Human Plasma Using Capillary Zone Electrophoresis Coupled by Flow Injection on line Solid Phase Extraction[J];CHEMICAL RESEARCH IN CHINESE UNIVERSITIES;1999-11
9 ZENG Ling jie,CHEN Mao,DENG Qiao hua,OUYANG Hui fang,YANG Dong sheng,CHEN Song guang (Baiyunshan TCM factory,Guangzhou Baiyunshan Pharmaceutical Co.,Guangzhou,510515);Study on the chromatography fingerprint of compound Tanshen tablet for its quality assessment[J];Academic Journal of Guangdong College of Pharmacy;2002-03
10  Wang Baoqi,Pang Zhigong,Hu Xiaolu (Pharmacy College,Xian Medical University,Xian,P.R.China 710061);Pharmacokinetic Study on Gentiopicin in Gentiana Macrophlla Pall[J];ACADEMIC JOURNAL OF GUANGDONG COLLEGE OF PHARMACY;1997-02
【Secondary References】
Chinese Journal Full-text Database 6 Hits
1 Tian Xuelian1,Lu Weidong1,Bao Deshan1,Tian Xueshan2(1.College of Biological Resources and Environmental Sciences,Qujing Normal University,Qujing Yunnan 655011;2.Qujing Disease Control Center,Qujing Yunnan 655000,China);Research on Methods of MAE and Salting-out for Extracting Berberine[J];Journal of Qujing Normal University;2009-03
2 MAO Jing-yuan1 WEI Guang-li2 WANG Heng-he1 GE Yong-bin1 LI Bin1 WANG Yi3 WANG Xian-liang3 GUO Yong-tie1 1.The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine 2.Tianjin Research Institute of Pharmacology 3.Tianjin University of Traditional Chinese Medicine;Influence of “Shenfu Injection” in Different Dosages on Serum Concentration and Pharmacokinetic Parameters of Digoxin in Rats with Heart Failure[J];Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai;2007-04
3 Wang Yan1, Ju Li-hua1, Chen Chang-le21Department of Basic Medicine, College of Medical Equipment and Bromatology, University of Shanghai for Science and Technology, Shanghai 200093, China; 2Shanghai Qigong Institute, Shanghai 200030, China;Application and safety of immunodepressant in organ transplantation[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2008-31
4 HE Fu-yuan~(1,2) ZHOU Hong-hao~1 LUO Jie-ying~2 1 Pharmacogenetic Research Institute,Institute of Clinical Pharmacology,Central South University,Changsha 410078,Hunan,China; 2 Department of Pharmaceutics,Hunan University of Tradition Chinese Medicine,Changsha 410004,Hunan,China;Establishment of a network pharmacokinetic model for multiple component drugs and parameter analyses[J];Chinese Journal of Clinical Pharmacology and Therapeutics;2007-12
5 Lin Jie,Ke Ai-bing,Zhang Xue-lian,Zheng Zhi-hui,Zhu Jing-tong,Lu Xin-hua,Li Ye-ying,Cui Xiao-lan,Shi Ying,Zhang Hua and He Jian-gong(New Drug Research & Development Center of North China Pharmaceutical Group Corporation,National Microbial Medicine Engineering & Research Center,Shijiazhuang 050015);2264 A and B,the inosine monophosphate dehydrogenase inhibitors from metabolites of microorganisms[J];Chinese Journal of Antibiotics;2008-08
6 HE Fu-yuan1,2,DENG Kai-wen3,WU De-zhi2,LIU Wen-long2,LIU Ping-an2,ZHOU Hong-hao1(1.Pharmacogenetic Research Institute,Central South University,Changsha,410078;2.Department of Pharmaceutics,Hunan University of Traditional Chinese Medicine,Changsha,410208;3.No.1 Hospital Affiliated to Hunan University of Traditional Chinese Medicine,Changsha,410007 China);Extraction kinetical deviations of berberine alkaloids in Rhizoma Coptidis and Zuojin Formulae[J];Chinese Traditional Patent Medicine;2009-09
China Proceedings of conference Full-text Database 4 Hits
1 HE Fu-yuan~(1,2) DENG Kai-wen~3 SHI Ji-lian~1 LIU Weng-long~2 LIU Ping-an~1 ZHOU Honghao~1 (1.Pharmacogenetic Research Institute,central South university Changsha(410078);2.Department of Pharmaceutics,Hunan University of Tradition Chinese Medicine Changsha(410208);3.The First Affinity Hospital,Hunan University of Tradition Chinese Medicine Changsha(410007) China);Study of the Chromatodynamics,A Pharmacodynamic Approach for the CMMF with Fingerprint Chromatrography and Validation of Herba Houttuyniae Injection[A];[C];2009
2 ;Study of the Chromatodynamics,A Pharmacodynamic Approach for the CMMFwith Fingerprint Chromatrography[A];[C];2009
3 ;Study of the Chromatodynamics,A Pharmacodynamic Approach for the Validation of Herba Houttuyniae Injection[A];[C];2009
4 ;Studies on Metabolic differences between original compounds and metabolites for Herba Houttuyniae Injection[A];[C];2009
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved