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《Military Medical Journal of South China》 2002-02
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Protective Effects of Eleutherosides Acupoint Application on Rats with Sleep Deprivation

LI Qiu - shi, WANG Sheng - xu. Department of Traditional Chinese Medicine, the First Military Medical University, Guangzhou, 510515  
Objective To study the protective effects of eleutherosides acupoint application on rats with sleep deprivation. Methods Forty rats were randomly divided into four groups: sleep deprivation (SD) group ; blank control (BC) group; test (TC) group and cage control (CC) group. The rats of SD, BC and TC groups were deprived of REM sleep for 96 hours by flower pot technique. Eleutherosides were applied to the certain acupoints of TC group rats. Plasma levels of Lactic Acid(LA), Cortisol(Cor) and Testoterone (T) were detected to evaluate the influence of REM SD on the rats and the protective effects of eleutherosides acupoint application on the rats with SD. Results The rats in SD group showed significantly milder response to REM SD in fatigue status, serum LA and T levels than the rats in BC group ( P 0.01). Although all the rats sleep - deprived for 96h showed significant increases in Cor levels compared with CC group ( P 0.01), insignificant difference in cor levels was found among the rats of these three sleep - deprived groups ( P 0.05). Conclusion Eleutherosides acupoint application can exert an protective effect on rats with REM SD pobably through modulating the functions of metabolism and neuroendocrine systems.
【Fund】: 全军“九五”医学科研规划资助项目(项目编号:96M061)
【CateGory Index】: R285
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