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《Hunan Agricultural Sciences》 2010-19
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The Determinants of Epigenetics of Cancer

ZHANG Pei-qi(College of Life Sciences,Nanjing Agricultural University,Nanjing 210095,PRC)  
The occurrence reason for cancer is basically the disorder of gene expression system,which is the regulation error of inheritable genes.The inheritable genes include oncogene,tumor suppressor gene and the gene related to DNA repair,etc..The epigenetic modifications involved in cancer,which including DNA methylation,histone modifications,RNA epigenetics which is caused by interaction and nucleosome remodeling,make some genes activated or silenced very exceptionally.So the epigenetic modifications make cells growing into an uncontrolled state.In this review,the changes of the action and mechanism of epigenetic genes in cancer cells were summarized.At the same time,the treatment prospects of applying principles of epigenetics to cancer were discussed.
【CateGory Index】: R730.2
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【Citations】
Chinese Journal Full-text Database 4 Hits
1 AN Qian, DONG Xiang-yang, ZHANG Jian-jun, HUANG Jin-feng, LI Li, CHENG Shu-jun, GAO Yan-ning (Cancer Institute (Hospital), Peking Union Medical College/ Chinese Academy of Medical Sciences, Beijing 100021, P. R. China);Studies on Inactivation of p16/CDKN2 Gene in Non-Small Cell Lung Cancer[J];Chinese Journal of Cancer;2001-06
2 TENG Li-Juan, LI KeDepartment of Molecular Epidemiology, Medical College, Shantou University, Shantou, Guangdong, 515041, P. R. China;Research Progress on the Relationship between Nutrition and Cancer Epigenetics——Histone Modification Mechanisms[J];Chinese Journal of Cancer;2007-09
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4 ZHANG Li-Li,WU Jian-Xin(Capital Institute of Pediatrics,Beijing 100020,China);DNA Methylation: An Epigenetic Mechanism for Tumorigenesis[J];Hereditas;2006-07
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Tao Wenhu Yu Zaicheng Department of Thoracic Surgesy,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,China;DNA methylation in lung cancer[J];Oncology Progress;2007-04
2 Tao Wenhu Jin Yongtang Yu Zaicheng Xue Shaoli Xu Yingchun Liu Xiao Tian Minhua Department of Thoracic Surgery,The First Affiliated Hospital of Anhui Medical University,Hefei,230022,China;The effects of p16 gene methylation on the risk of non-small cell lung cancer[J];Oncology Progress;2007-04
3 LIU Jin yi, AN Qian, SUN Wen yue, HUANG Jin feng, PAN Qin jing, CAO Jia, CHENG Shu jun, GAO Yan ning (Department of Hygiene Toxicology, College of Military Preventive Medicine, Third Military Medical University, Chongqing 400038, China);Analysis of p16 hypermethylation in sputum samples from lung cancer patients[J];Acta Academiae Medicinae Militaris Tertiae;2003-19
4 Pu-Yuan Wu,1,2 Yi-Mei Fan1,2 and Ya-Ping Wang1,2 1. Department of Medical Genetics, Medical School, Nanjing University, Nanjing, Jiangsu 210093, P. R. China 2. Jiangsu Key Laboratory of Molecular Medicine, Nanjing, Jiangsu 210093, P. R. China;Germ-line epimutations and human cancer[J];Chinese Journal of Cancer;2009-12
5 YU Li (Department of Bio-chemistry,Baoshan College,Baoshan,Yunnan 678000);Study and Development of Epigenetics[J];Journal of Anhui Agricultural Sciences;2010-02
6 GUO Xiujuan,SHEN Li,Zhang Hong,et al.Department of Clinical Laboratory,The Fourth Hospital of Hebei Medical University,Shijiazhuang 050051;The detection and clinical diagnostic value of promoter hypermethylation of p16 gene in serum and tissue of lung cancer patients[J];Hebei Medical Journal;2008-06
7 LI Bangyin1,2, ZHANG Kaitai2, HUO Yanying2, et al. 1.The Second Affiliated Hospital, P.L.A General Hospital., Beijing 100091, China; 2.Beijing Institute of Radiation Medicine, Beijing 100850,China);Study on the mutations and Homozygous deletions of MTAP and p16 in NSCLC[J];Journal of Clinical Pulmonary Medicine;2007-06
8 ZHANG Ai-hua~1 CHEN Qiang~1 LI Jian~1 PAN Xue-li~1 ZHAO Zhuan-di~1 HUANG Xiao-xin~2 CEN Du-Cai~2 (1.School of Public Health, Guiyang Medical College, Guizhou, Guiyang 550004, China; 2.The 44th Hospital of PLA, Guizhou, Guiyang 550009, China);Study on the Promoter Hypermethylation of the DNA Repair Gene O~6-methylguanine-DNA Methyltransferase and mRNA Expression in Victims of Endemic Arsenism Caused by Coal-burning[J];Journal of Environmental & Occupational Medicine;2008-05
9 ZHANG LI-JIAN (Department of Oncology, The Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, China);A PRELIMINARY STUDY OF RADIOTHERAPEUTIC TARGET REGION DESIGN FOR NSCLC BY DETECTION OF p16 GENE METHYLATION[J];Medical Journal of Qilu;2007-04
10 LI Shi-jun,YUAN Hong,LIU Xin-yuang(Department of Clinical Labortory,the First Affiliated Hospital,Dalian Medical University,Liaoning Dalian 116011,China);The Clinical Study of the Methylation in Gene p16 in Diagnose Cancer of Lung[J];Journal of Medern Laboratory Medicine;2005-05
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 AN Qian, DONG Xiang-yang, ZHANG Jian-jun, HUANG Jin-feng, LI Li, CHENG Shu-jun, GAO Yan-ning (Cancer Institute (Hospital), Peking Union Medical College/ Chinese Academy of Medical Sciences, Beijing 100021, P. R. China);Studies on Inactivation of p16/CDKN2 Gene in Non-Small Cell Lung Cancer[J];Chinese Journal of Cancer;2001-06
2 LIU Jin-Yi~(1,2),AN Qian~1,ZHANG Jian-Jun~1,LEI Wen-Dong~1,CHENG Shu-Jun~1,GAO Yan-Ning~(1,① ) (1.Cancer Institute (Hospital),Peking Union Medical College/Chinese Academy of Medical Sciences,Beijing 100021,China; 2.Preventive Medicine College,Third Military Medical University,Chongqing 400038,China);Screening of Hypermethylated DNA Fragments in Tumor Tissue Derived from Patients with Lung Cancer[J];Acta Genetica Sinica;2004-04
3 ZHANG Yong-Biao, CHU Jia-You(Department of Genetics, Institute of Medical Biology, Peking Union Medical College, Kunming 650118, China);Progress of Research on Epigenetic and Human Disease[J];Hereditas(Beijing);2005-03
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