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《Hunan Agricultural Sciences》 2010-19
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The Determinants of Epigenetics of Cancer

ZHANG Pei-qi(College of Life Sciences,Nanjing Agricultural University,Nanjing 210095,PRC)  
The occurrence reason for cancer is basically the disorder of gene expression system,which is the regulation error of inheritable genes.The inheritable genes include oncogene,tumor suppressor gene and the gene related to DNA repair,etc..The epigenetic modifications involved in cancer,which including DNA methylation,histone modifications,RNA epigenetics which is caused by interaction and nucleosome remodeling,make some genes activated or silenced very exceptionally.So the epigenetic modifications make cells growing into an uncontrolled state.In this review,the changes of the action and mechanism of epigenetic genes in cancer cells were summarized.At the same time,the treatment prospects of applying principles of epigenetics to cancer were discussed.
【CateGory Index】: R730.2
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