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《农业科学与技术(英文版)》 2015-10
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Inhibitory Effect of Buddlejasaponin Ⅳ on Hepatocarcinoma 22(H_(22)) in Mice

Yueyuan CHEN;Yonglin HUANG;Jiejing CHEN;Fenglai LU;Dianpeng LI;Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Chinese Academy of Sciences;Guangxi Key Laboratory of Metabolic Diseases Research;  
[Objective] This study aimed to investigate the inhibitory effect of buddlejasaponin IV on growth of hepatocarcinoma 22(H22) tumor in mice. [Method] The H22 tumor cells were transplanted in the right axillary skins of mice. The tumorbearing mice were randomly divided into five groups, including control group, CTX group(20.0 mg/kg) and buddlejasaponin IV treatment groups(0.25, 0.50 and 1.00mg/kg). There were 10 mice in each group. During the treatment, the body weights and survivals of mice in all groups were recorded. The buddlejasaponin IV was injected into the abdominal cavities of mice, which lasted for 10 consecutive days. All the mice were slaughtered the next day. The tumors in the abdominal cavities were tanked out and weighed. The tumor inhibition rate, spleen index and thymus index,as well as SOD activity, MDA content, GGT activity and AKP activity in serum were determined. [Result] Compared with the control group, the high- and middledosage buddlejasaponin IV treatment groups all showed significant(P0.01) inhibitory effects on transplanted H22 tumor in mice with tumor inhibition rates of 56.96%and 50.63%, respectively. Compared with those in the control group, the SOD activity of mice in the high-dosage buddlejasaponin IV treatment group was significantly increased(P0.05), and the MDA contents, GGT and AKP activities in mice in the high-, middle- and low-dosage buddlejasaponin IV treatment groups were all significantly reduced(P0.01). There were no significant differences in all the indexes,except SOD activity, between the CTX and control groups. [Conclusion] Buddlejasaponin IV has certain inhibitory effect on H22 tumor, of which the mechanism might be related to antioxidation capacity in body.
【Fund】: Supported by Bagui Scholar Program of Guangxi;Scientific Research and Technological Development Program of Guilin(20110201);; Open Fund of Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization(181H2011-03)~~
【CateGory Index】: R285.5
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