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Therapeutical effect of taraxacum mongo on rats after acute brain injury

Zhang Zhe,Yan Wenhai,Yang Bo.The Basic Medical College of Zhengzhou University,Zhengzhou 450052,China  
Objective To observe the effect of TM on TBI,and to investigate the relation between the mechanisms of TM and the activities of SOD and GSH-PX.Methods Forty-eight male healthy Sprague-Dawley rats were randomly divided into 6 groups as follow :normal control group(C group),sham surgery group(SS group),traumatic brain injury group(TBI group,PR group),low dose TM treated group(LDT group),medium dose TM treated group(MDT group),high dose TM treated group(HDT group),each group had 8 rats.TBI model was established by using improved Marmarou' method.Biochemical assay was used to observe the effects of TM on MDA contents,activities of SOD,and the activities of GSH-PX.Results The MDA content in LDT and MDT were significantly lower than those in TBI group(P0.05);The MDA content in HDT was significantly lower than that in TBI group(P0.01);Compared with the TBI group,the activities of SOD and GSH-PX in LDT and MDT group significantly increased(P0.05);The activities of SOD and GSH-PX in HDT were significantly higher than those in TBI group(P0.01).Conclusion TM can increase the reduced level of SOD and GSH-PX activity,and inhibit the level of lipid peroxidation after TBI,and therefore has neuroprotective actions after acute traumatic brain.
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