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《Journal of Henan Normal University(Natural Science)》 2010-06
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Effects of Tea Polyphenols on Mucosa Structures and 5-Hydroxytryptamin Secretion of Small Intestine in Mouse

TANG Chao-zhi,YUN Xiao-jing,ZHANG Ya-jie,YANG Hai,SUN Jin-xia,ZHANG Wen-xue(College of Life Sciences,Henan Normal University,Xinxiang 453007,China)  
Objective The paper studies the effects of tea polyphenols(TP) on mucosa structures and 5-hydroxytryptamin(5-HT) secretion of small intestine in mouse.Methods Twenty-eight Kunming mice were classified randomly into four groups: A,B,C and D,every group had 7 mice.Group A was administered intragastrically with 0.20 ml/d deionized water for 30 days.Respectively,Group B,C and D were administered intragastrically with 0.50,1.00,2.00 mg/d TP for 30 days.On the 31st day,the research decided the 5-HT content of serum every mouse by radioimmunoassay,and dissected small intestine to fix with formalin,then made paraffin embedded section,detected histological structure of small intestine by H-E dyeing,counted 5-HT endocrine cells of unit area in small intestine by immunohistochemistry technology.The results were compared with Group A,significantly,the serum 5-HT content of Group B,C and D was low,alinement of intestine villus was loose,intestine gland was atrophic,quantity of 5-HT endocrine cells was less.Conclusion Results reveal that TP had an inhibiting effect on hyperblastosis and 5-HT secretion of small intestine in mouse.
【Fund】: 国家自然科学基金青年基金(51008119);; 河南师范大学青年科学基金;; 河南师范大学大学生创新性实验基金资助;; 河南省动物学重点学科基金
【CateGory Index】: R285
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