Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《》 1986-01
Add to Favorite Get Latest Update

THERAPEUTIC EFFECTS ON ARRHYTHMIAS INDUCED BY EXPERIMENTAL MYOCARDIAL REPERFUSION IN RAT

You Jialu Lu Yanzhen Wang Yanru Han Zhengping Luo ZhengyaoDepartment of Pathophyslology, Hunan Medical College  
The purpose of this study is to evaluate the effects of SOD, DMSO, Verapamil and Anisodamine (654-2) on arrhythmias induced by myocardial reperfusion in rat. The arrhythmias was reproduced by 5 min occlusion of the left main coronary artery and subsequent release for 10 min in 63 anaesthetized rats. The experimental animals were divided into 5 groups: SOD group (N=11); DMSO group (N = 10); verapamil group (N=10); 654-2 group (N=15) and Saline control group (N=17). Drugs were given intravenously during the period 1 min before and 30 sec after the release. Results indicated that the incidence of arrhythmias induced by myocardical reperfusion was 88.2% in saline control group, 27.3% in SOD group, 40% in DMSO group, 30% in Verapamil group and 46.7% in 654-2 group respectively. Compared with the control group, all the incidences in the experimental groups were significantly lowered (p0.05). The results obtained from SOD and DMSO supported the hypothesis that the oxygen-free radical plays a key role in the pathogenesis of reperfusion syndrome. The protective effect of anisodamine (654-2) in shock management was proved, however in arrhythmias induced by myocardial reperfusion it has never been reported; its mechanism remains to be elucidated.
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 3 Hits
1 YAO Xiu-Juan, YU Bao,Rong and TAN Yue-Hua Department of Pharmacology;Effects of Anisodamine on Reperfusion-Induced Arrhythmias and Hemodynamics in Rabbits[J];Journal of The Fourth Military Medical University;1990-02
2 Luo Han;You Jialu;Han Zhengping;Xiao Zihui;Luo Zhengyao;Chen Yien~(1)) Department of Pathophysiology,Hunan Medical College;PROTECTIVE EFFECT OF SUPEROXIDE DISMUTASE MADE IN CHINA ON MYOCARDIAL INJURY DURING ISCHEMIC-REPERFUSION[J];;1987-04
3 You Jialu Tian Hecun Xiao Zihui Han Zhengping Luo ZhengyaoDepartment of Pathophysiology;PROTECTIVE EFFECT OF ANISODAMINE ON MYOCARDIAL FUNCTION DURING ISCHEMIC REPERFUSION[J];;1988-01
【Citations】
Chinese Journal Full-text Database 1 Hits
1 Hu Ping You Jialu Luo ZhengyaoDepartment of Pathophysiology, Hunan Medical College;THE MODEL OF RAT HEART REPERFUSION SYNDROME[J];;1986-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Tian Hecun, ( Department of Pathophysiology, Bengbu Medical College, Anhui );THE MEASUREMENT OE MYOCARDIAL CONTRAC- TIBILITY AND OCCURENCE OF ARRHYTHMIAS IN RAT HEART OF POST-ISCHEMIC REPERFUSION[J];Journal of Bengbu Medical College;1987-02
2 JIANG Jianying,WANG Yingyuan,GAO Cairong(Department of Pathology,Baotou Medical College,Baotou 014010,China);An Experimental Study on Apoptosis of Myocardial Cell in Acute Myocardial Ischemia of Rats[J];Journal of Baotou Medical College;2006-04
3 Zhao Xianxian, Zhang Tonghua, Qin Yongwen, Zhou Bingyan, Ding Hongjun (Department of Cardiology, Changhai Hospital, Shanghai, 200433);Effects of Dazoxiben, a Selective Thromboxane Synthetase Inhibitor, on Reperfusion Arrhythmias in Rats[J];Academic Journal of Second Military Medical University;1993-04
4 YAO Xiu-Juan, YU Bao,Rong and TAN Yue-Hua Department of Pharmacology;Effects of Anisodamine on Reperfusion-Induced Arrhythmias and Hemodynamics in Rabbits[J];Journal of The Fourth Military Medical University;1990-02
5 Hu Ping You Jialu Luo ZhengyaoDepartment of Pathophysiology, Hunan Medical College;THE MODEL OF RAT HEART REPERFUSION SYNDROME[J];;1986-01
6 Luo Han;You Jialu;Han Zhengping;Xiao Zihui;Luo Zhengyao;Chen Yien~(1)) Department of Pathophysiology,Hunan Medical College;PROTECTIVE EFFECT OF SUPEROXIDE DISMUTASE MADE IN CHINA ON MYOCARDIAL INJURY DURING ISCHEMIC-REPERFUSION[J];;1987-04
7 You Jialu Tian Hecun Xiao Zihui Han Zhengping Luo ZhengyaoDepartment of Pathophysiology;PROTECTIVE EFFECT OF ANISODAMINE ON MYOCARDIAL FUNCTION DURING ISCHEMIC REPERFUSION[J];;1988-01
8 CUI Bing , HAN Jianwei, YAO Mengying Nanyang Center Hospital , Nanyang 473009, China;Cardioprotective Effects of Taurine on Ischemia-reperfusion Injury[J];Journal of Medical Forum;2005-02
9 Su Xiaoling, Cheng Yanbin, Wang Rong, Liu Yongnian, Wang Jianguo,Zhou ShiYing Zhang Wei The Department Anatomy of Lanzhou Medical College(73000);THE INFLUENCE OF VERAPAMIL ON THE PROTEINEXPRESSION OF bcl-2 GENES OF ISCHEMIA-REPERFUSION MYOCARDIAL CELL[J];Journal of Qinghai Medical College;2002-03
10 Wang Rong Su Xiaoling Zhou Baili Long Qifu Department of Biochemistry, Qinghai Medical College(810001);THE INFLUENCE OF VERAPAMIL ON PLAMSA EDOTHELIN ON THE MODEL OF MYOCARDIAL ISCHEMIA-REPERFUSION INJURY[J];Journal of Qinghai Medical College;2004-02
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Dept Pathophysiology, Tang Chaoshu;CALCIUM-ANTAGONIST EFFECT OF ANISODAMINE(654-2)[J];;1985-03
2 Tang Chao-shu Department of Pathophysiology;ANOXIA-REOXYGENATION DAMAGE TO RAT'S Ca-RESISTANT VENTRICULAR MYOCYTES AND SALUTARY EFFECTS OF FRUCTOSE 1.6-DIPHOSPHATE[J];;1987-05
3 Yao Xiujuan(Department of Pharmacology);Antiarrhythmic Effects of Anisodamine in Animal Models[J];Journal of The Fourth Military Medical University;1987-01
4 YAO Xiu-Juan, YU Bao,Rong and TAN Yue-Hua Department of Pharmacology;Effects of Anisodamine on Reperfusion-Induced Arrhythmias and Hemodynamics in Rabbits[J];Journal of The Fourth Military Medical University;1990-02
5 ZHANG Ying-Min, ZHAO De-Hua and SHENG Bao-HengDepartment of Anesthesiology, Xijing Hospital Department of Pharmacology;Antiarrhythmic Effects of Diethyl 2,6 - dimethyl - 4 (furnyl)-1, 4- dihydropyridine - 3 ,5- dicarboxylate[J];Journal of The Fourth Military Medical University;1990-03
6 LIU De - Qiang, PANG Zhong - Qing, ZHAO De - Hua and SHENG Bao- Heng Department of Pharmacology Department of Military Hygiene;Protective effect of furyl - dihydropyridine I on acute myocardial ischemia - reperfusion in rats[J];Journal of The Fourth Military Medical University;1991-05
7 YAO Xiu-Juan GUI Yi YU Bao-Rong TAN Yue-Hua and GUO Zheng-Ren Department of Pharmacology Department of Chemistry;Protection by anisodamine against postischemic reperfusion arrhyth-mia and lipid peroxidation in anesthetized rats[J];Journal of The Fourth Military Medical University;1992-05
8 Ge Ming Luo Zhengyao Luo Han You JialuDepartment of Pathophysiology, Hunan Medical College;EFFECT OF ANISODAMINE ON PULMONARY FUNCTIONOF DISAGGREGATING PLATELET MICROAGGREGATES IN CANINE ENDOTOXEMIA[J];;1985-01
9 Hu Ping You Jialu Luo ZhengyaoDepartment of Pathophysiology, Hunan Medical College;THE MODEL OF RAT HEART REPERFUSION SYNDROME[J];;1986-01
10 Guo Dianling Luo Han Chen Guangwen Luo Zhengyao Department of Pathophysiology, Hunan Medical University;EFFECT OF ANISODAMINE ON ARRHYTHMIAS IN CALCIUM PARADOX ISOLATED RAT HEARTS[J];;1989-02
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 Ding Kuke; Zeng Yanjun (Biomechanics and Medical Information Institute, Beijing Polytechnic University, Beijing, 100022 ) Hu Jinlin; Song Xin (PLA General Hospital, Beijing, 100853 );The Effects of Post-Ischemic Reperfusion to Cerebral Microvessels and Lung Etc.orgins[J];JOURNAL OF BEIJING POLYTECHNIC UNIVERSITY;2000-01
2 LIU Mei-dong,YOU Jia-lu,ZHONG Lin.Department of Pathophysiology,Hunan Medical University,Chang-sha,410078,China$$$$;The Inhibitory Effect of Anisodamine on SNP-induced Apoptosis in Bovine Endocardial Endothelial Cell[J];JOURNAL OF CHINESE PHYSICIAN;2000-10
3 YAO Xiu-Juan GUI Yi YU Bao-Rong TAN Yue-Hua and GUO Zheng-Ren Department of Pharmacology Department of Chemistry;Protection by anisodamine against postischemic reperfusion arrhyth-mia and lipid peroxidation in anesthetized rats[J];Journal of The Fourth Military Medical University;1992-05
4 XV Li-Xian, LI Yu-Qing, CHEN Xin-Hai and ZHAO De-HuaGroup of Anesthesiology, Pharmacy, Stomatological College 'Department of Pharmacology;Effects of hexametazidine on arrhythmias induced by ischemia and reperfusion[J];Journal of The Fourth Military Medical University;1992-06
5 Guo Dianling Luo Han Chen Guangwen Luo Zhengyao Department of Pathophysiology, Hunan Medical University;EFFECT OF ANISODAMINE ON ARRHYTHMIAS IN CALCIUM PARADOX ISOLATED RAT HEARTS[J];;1989-02
6 Xiaoxian1, W u W eikang 2, Chen Jianp ing2, Luo H anchuan2, Tan H ongm ei2, Zhou Lin2, Lu Li2, Liang Tianw en21 Departm ent of Cardiology, The three Affiliated Hospital,2 Departm ent of Pathophysiology, Sun Yat Sen university of M edical Sci;<Abstract>Effects of Fufang Xueshuantong capsule on hem odynam ics inm yocardialischem ic canines[J];;1999-03
7 YAO Xiu juan 1, JIA Min 1, QIN Wei jun 2, FANG Zheng qing 3 1Department of Pharmacology, 2Xijing Hospital, 3Department of Pathology, Xi′an 710032, Shaanxi,China;Protective effect of anisodamine on myocardium and erythrocyte in postburn rats[J];CHINESE HEART JOURNAL;2000-01
8 LIU Guang-Yu, WU Dong-Mei, RAO Man-RenDept Cardiovascular Pharmacology, Nanjing Medical College, Nanjing 210029;Protective effects of anisodamine on diastolic function of ischemic myocardium in isolated working rat heart[J];Chinese Journal of Pharmacology and Toxicology;1991-02
9 (Wang Yongliang Guo Xinping Department of tuberculosis The first affiliate hospital of Xinxiang medical college Weihui city, Henan province,453100 China);Experimental Study on the Acute Lung Injury in Rats of Cerebral Ischemia[J];Medicine Industry Information;2005-24
10 Liu Guiming, Ding Xueqin, Xu Guozhong, Wang Junke, Sheng Zhuoren(Department of Anesthesiology, The First Clinical College,China Medical University, Shenyang, 110001);Effect of Anisodamine on Myocardial Reperfusion Injury[J];Journal of China Medical University;2001-01
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Jiang Zonglai;Hu Haitao;Director Ling Fengdong Department of Anatomy, Xian Medical College;Anatomical Observation on the Coronary Arteries of the Rat Heart[J];Journal of Xi'an Jiaotong University(Medical Sciences);1982-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved