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EFFECT OF ENDOTOXIN ON BOVINE PULMONARY ENDOTHELIAL CELL AND PROTECTIVE ACTION OF ANISODAMINE

Rao Huaping Luo Zhengya You Jialu Luo HanDepartment of Pathophysiology, Hunan Medical University  
The effect of E.coli endotoxin and the protective action of anisodamine (654-2) on the bovine pulmonary endothelial cell (BPEC) in vitro were investigated. The percentage of pyknotic cells, the releasing of lactate dehydrogenase ( LDH) , the amount of malondialdehyde ( MDA) and the percentage of neutrophils adhering on the BPEC were measured.The results showed that: endotoxin can injure the BPEC directly and through the activated neutrophils; anisodamine has a protective effect on this kind of damage.
【Fund】: 国家自然科学基金
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