Ischemic preconditioning reduces lung ischemia reperfusion injury in vivo rabbits
Li Guohu Chen Shengxi Lu Erxiong Hu Tiefei (Department of Cardiothoracic Surgery, Hunan Medical University, Changsha 410008)
Thirty male Japanese white rabbits were randomized into two groups. Fifteen rabbits were treated with ischemic preconditioning(their left lung hilus clamped for 10?min and released for 15?min; Group IP). Fifteen rabbits were not treated with ischemic preconditioning(Group C). Then the left lung hilus of both groups were occlused for 60?min and reperfused for 60?min. The results were that after 60?min of reperfusion, in Group IP, the contents of angiotensin Ⅱ(AngⅡ) and artery oxygen tension(PaO 2) in blood samples and the contents of superoxide dismutase in lung tissue were significantly higher, while the mean pulmonary artery pressure in blood samples, the wet/dry ratio and malondialdehyde content in lung tissue were significantly lower than those in Group C; Histological findings showed less damage in Group IP. It is suggested that lung ischemic preconditioning can reduce normothermic rabbit lung ischemia reperfusion injury.
【CateGory Index】： R655