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Effects of danshen and shengmaiye on glomerulosclerosis by adriamycin in rats

Peng Youming Liu Fuyou Luo Jian Liu Ruihong (Department of Internal Medicine, The Second Affiliated Hospital, Hunan Medical University, Changsha 410011)  
To investigate the effects of danshen(Salvia plectranthoides Griff.) and shengmaiye (Panax ginseng C.A.Mey, Ophiopogon japonicus Ker Gawl and Schisandra chinensis Baill) on glomerulosclerosis induced by adriamycin in SD rats. Method: Left kidney of the animals was removed and after 7 days, adriamycin(6?mg·kg -1 ) was injected through tail vein, so as to establish an animal disease model. Then danshen or shengmaiye was injected to peritoneal cavity of the rats. All rats were killed by the end of the 8th week. Hemoglobin, BUN, cholesterol and protein in urea within 24 hours(ur Pro/24h) were detected. Ⅳ collagen(Ⅳ col.) and laminin(LN) of renal cortex were determined by ELISA. The quantitation of Ⅳ col and LN in glomerular mesangial area was analyzed by computer pictures. Results: Compared with model danshen group(Group Ⅲ), model shenmaiye group(Group Ⅳ) and normal control group(Group Ⅰ), BUN, cholesterol(Ch) and ur Pro/24h were increased obviously and hemoglobin(Hb) was decreased in model control group(Group Ⅱ). The values of BUN, Ch and Ur Pro were lower in Group Ⅲ and Group Ⅳ than those in Group Ⅱ and higher than those in Group Ⅰ(P0.05). The quantitation of Ⅳ col and LN within renal cortex and mesangial area was less in Group Ⅲ and Group Ⅳ than that in Group Ⅱ and more than that in Group Ⅰ(P0.05 or P0.01). Conclusion: Dansheng and shengmaiye may play an important role in the treatment of glomerulosclerosis in rats.
【CateGory Index】: R286;R692.6
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