Clinical research of ischemic preconditioning on lung protection
Chen Shenxi Li Guohu Long long (Department of Cardiothoracic Surgery, Xiangya Hospital, Hunan Medical University, Changsha 410008)
Twenty patients, who only need to occlude main pulmonary artery underwent pulmonectomy, were randomized into two groups. Ten patients were treated with ischemic preconditioning(IP). Their main pulmonary artery was clamped for 10 minutes and released for 10 minutes(Group IP). Ten patients were not treated with ischemic preconditioning(Group C). The results showed that the content of calcitonin gene related peptide(CGRP) in Group IP was significantly higher than that in Group C after iscehmic preconditioning. After lung reperfusion for 30 minutes, the value of superoxide dismutase and pulmonary vein blood oxygen tension in Group IP was significantly higher than that in Group C. It is evident that ischemic preconditioning could reduce normothermic human lung ischemia reperfusion injury. The possible mechanism is that ischemic preconditioning increases the production of endogenous CGRP.