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《Bulletin of Hunan Medical University》 2001-02
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Analysis of monoclonal protein in 72 cases of multiple myeloma

YANG Jun jie 1, ZHANG Guang sen 1, CHEN Xin rui 2, et al (1.Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha 410011, China 2.Clinical Laboratory, The Second Xiangya Hospital, Central South University, Chan  
Serum and urinary monoclonal proteins (M protein) were measured in 72 cases of multiple myeloma (MM) using rate nephelometry. In IgG and IgA types of MM, the level of immunoglobulin (Ig) corresponding to the malignant isotype was significantly higher and that of Ig uncorresponding to the malignant isotype lower than the normal level. The light chain corresponding to the malignant isotype in serum was increased and the light chain uncorresponding to that in serum was decreased either kappa IgG, IgA types or lambda IgG, IgA types. Either kappa LC or lambda LC type of MM, the serum light chain corresponding to the malignant isotype was in the normal range and uncorresponding to that was decreased,and the corresponding light chain in urine was significantly elevated. Kappa/lambda ratio in serum and urine was all significantly abnormal in IgG, IgA, and LC types of MM.Our data suggest that any quota among kappa light chain20?g.L 1 or5?g·L 1 ,lambda light chain10?g·L 1 or2?g·L 1 in serum and kappa/lambda ratio5 or0.75 in serum and urine has an important value for diagnosing MM.
【Fund】: 国家自然科学基金部分资助!( 3 95 70 3 2 4)
【CateGory Index】: R733.3
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【References】
Chinese Journal Full-text Database 2 Hits
1 ;Analysis of humoral immunological features in 2007 M protein positive patients[J];Academic Journal of Second Military Medical University;2004-12
2 LI Hua,ZHAI Tan.Department of Clinical Laboratory,Donghua Hospital of Zhongshan Medical University,Dongguan,Guangdong 523100,China;Role of serum κ/λ ratio detection in multiple myeloma diagnosis[J];International Journal of Laboratory Medicine;2006-02
【Co-references】
Chinese Journal Full-text Database 5 Hits
1 QI Wei-Min;GUO Li(Department of Clinical Laboratories, Tangdu Hospital, Fourth Military Medical University, Xi'an710038);Diagnostic application of quantitation of kappa,lambda light chains and its ratio in patients with multiple myeloma[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;1998-04
2 Xu Jiangxia,Liu Ming, Wan Jianxin,Yu Chunshan.Department of Laboratory,Fourth Affiliated Hespital,Jiangxi Medical college,Nanchang 330003;Determination of the immunoglobulin and light chains and its clinical significance in patients with Multiple Myeloma[J];JIANGXI JOURNAL OF MEDICAL LABORATORY SCIENCES;2000-01
3 MIAO Lishao, YU Xiongwen. Clinical Laboratory, The People's Hospital of ZhongShan,Guangdong Zhongshan 528403.;Seroimmunological analysis of 28 multiple myeloma cases[J];Shanghai Journal of Medical Laboratory Sciences;2001-01
4 CHEN Shilun, LI Yanchen, ZHANG Peng, et al. Beijing Chaoyang Hospital Affiliated to Capital University of Medical Sciences, Beijing 100020, China;A clinical analysis of 798 cases of M protein positive patients[J];Chinese Journal of Internal Medicine;2001-06
5 Hou Jian,Kong Xiantao,Liu Yan, et al.Chang Zheng Hospital, 2nd Military Medical University, Shanghai 200003;Seroimmunological features of 337 cases of monoclonal gammapathies[J];Chinese Journal of Laboratory Medicine;1997-02
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 MAO Xiao-Bei1,2,CHEN Xie-Qun1,ZHAI Yong-Ping2,LIANG Rong1,GAO Guang-Xun1,MA Guo-Guang2,YU Ya-Ping2,LI Feng21Department of Hematology,Xijing Hospital,The Fourth Military Medical University,Xi′an 710032,Shaanxi Province,China;2Department of Hematology,Nanjing General Hospital of Nanjing Military Area,Nanjing 210002,Jiangsu Province,China;Measurement of Serum Free Light Chains and Its Clinical Significance in 20 Newly Diagnosed Patients of Multiple Myeloma[J];Journal of Experimental Hematology;2008-04
2 Wan Tang,Zhang Min,Gong Jing-lian,Wang Xiao-gang,Huang Guang-ping(The First Hospital of Nanchang City,Nanchang 330008,China);Clinical value of serum albumin electrophorsis for multiple myeloma[J];Chinese Journal of Health Laboratory Technology;2007-10
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