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《Bulletin of Hunan Medical University》 2001-02
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Analysis of monoclonal protein in 72 cases of multiple myeloma

YANG Jun jie 1, ZHANG Guang sen 1, CHEN Xin rui 2, et al (1.Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha 410011, China 2.Clinical Laboratory, The Second Xiangya Hospital, Central South University, Chan  
Serum and urinary monoclonal proteins (M protein) were measured in 72 cases of multiple myeloma (MM) using rate nephelometry. In IgG and IgA types of MM, the level of immunoglobulin (Ig) corresponding to the malignant isotype was significantly higher and that of Ig uncorresponding to the malignant isotype lower than the normal level. The light chain corresponding to the malignant isotype in serum was increased and the light chain uncorresponding to that in serum was decreased either kappa IgG, IgA types or lambda IgG, IgA types. Either kappa LC or lambda LC type of MM, the serum light chain corresponding to the malignant isotype was in the normal range and uncorresponding to that was decreased,and the corresponding light chain in urine was significantly elevated. Kappa/lambda ratio in serum and urine was all significantly abnormal in IgG, IgA, and LC types of MM.Our data suggest that any quota among kappa light chain20?g.L 1 or5?g·L 1 ,lambda light chain10?g·L 1 or2?g·L 1 in serum and kappa/lambda ratio5 or0.75 in serum and urine has an important value for diagnosing MM.
【Fund】: 国家自然科学基金部分资助!( 3 95 70 3 2 4)
【CateGory Index】: R733.3
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【Secondary References】
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