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《Bulletin of Hunan Medical University》 2002-04
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Efficacy of erigeron on diabetic peripheral neuropathy

WU Jing, ZHONG Hui ju, SUN Zhi xiang, et al. (Department of Endocrinology, Xiangya Hospital, Central South University, Changsha 410008, China)  
Objective To investigate the efficacy of erigeron on diabetic peripheral neuropathy (DPN), and to obsreve the changes of erythrocyte aldose reductase (AR) activity and serum nitric oxide (NO) level. Methods Sixty four patients with DPN were randomly divided into two groups: erigeron treated group and mecobalamin controlled group. The treatment group received daily erigeron 50 mg, while the control group received daily mecobalamin 500 μg for 3 weeks. The changes of clinical symptoms, sensory nerve conduction velocity (SNCV), AR activity and NO level were observed. Results The AR activity was higher, but the NO level was lower in the diabetic patients before the treatment than those in the healthy controls (P0.01); the AR activity decreased, while the NO level increased significantly after the erigeron treatment, but these parameters had no significant changes after the mecobalamin treatment. The total effective rate and marked effective rate of erigeron in relieving clinical symptoms were significantly higher than those of mecobalamin (85.29% vs 73.33%, 20.59% vs 10.00%, P0.01). Both erigeron and mecobalamin could markedly improve SNCV, but the rising degree of SNCV in the erigeron treated group was higher than that in the mecobalamin controlled group (P0.01). Conclusion Erigeron is able to inhibit erythrocyte AR activity and to increase serum NO level; it can relieve clinical symptoms of diabetic neuropathy, and prompt sensory nerve conduction velocity. The efficacy of erigeron on DPN is better than that of mecobalamin.
【CateGory Index】: R587.2
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