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Oxidative and anti-oxidative effects of ambroxol on acute hydrochloric acid-induced lung injury in rats

ZHAO Shuang-ping *,GUO Qu-lian,WANG Rui-ke,WANG E (ICU of Xiangya Hospital,Central South University,Changsha 410008,China)  
Objective To evaluate the protective effect of ambroxol on acute hydrochloric acid- induced lung injury in rats. Methods Thirty pathogen-free SD rats were randomly divided into 3 groups: Group A (n=10) served as control group, and received intracheal instillation of normal saline (NS, pH5.3,1.2 ml/kg) with pre-treatment of intraperitoneal NS;Group B (n=10)received intracheal instillation of hydrochloric acid /NS (pH1.25,1.2 ml/kg) with pre-treatment of intraperitoneal NS; and Group C received intracheal instillation of hydrochloric acid /NS (pH1.25,1.2 ml/kg) with pre-treatment of intraperitoneal ambroxol (50 mg/kg/d, 3 days). Five hours after the instillation of the injury vehicle, the arterial gas was examined, the levels of superoxide dismutase (SOD), malondialdehyde(MDA) in the blood and homogenate of harvested lung were assayed respectively. Results PaO 2 in Group B was significantly lower than that in Group A and C (P0.01),and pH and PaCO 2 in the 3 groups had little difference (P0.05).MDA in the lungs of Group B increased obviously,and levels of SOD in the lung and blood decreased significantly in Group B (Group B vs Group A,P0.01).Levels of SOD of Group C in the lung and blood were markedly higher than those of Group B (P0.01),MDA of Group C was obviously lower than that of Group B (P0.01),and MDA of blood in the 3 groups had no significant difference (P0.05).Conclusion Ambroxol can inhibit lipid peroxidation and increase antioxidant activity, which may be one of the mechanisms in protecting lung tissue from hydrochloric acid-induced injury.
【CateGory Index】: R965
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【References】
Chinese Journal Full-text Database 1 Hits
1 LI Zhaoxia,LIU Dijun,FANG Zhongliang (Department of Pediatrics,the Second Hospital of Yueyang,Yueyang 414000,China);A big dose of Mucosolvin to cure the children's acute lung injury[J];China Medical Herald;2009-16
【Citations】
Chinese Journal Full-text Database 1 Hits
1 ZHANGBo ,LIUYouning .Departmentof RespiratoryDiseases,GeneralHospitalofPLA ,Beijing 10 0 85 3 ,China;Prophylaxis against ventilator induced lung injury by Ambroxol[J];NATIONAL MEDICAL JOURNAL OF CHINA;2000-01
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 HU Guo-dong1, CAI Shao-xi1, CHEN Ying-hua2, GAO Feng1Department of Respiratory Diseases, Nanfang Hospital, 2Department of Histology and Embryology, Southern Medical University, Guangzhou 510515, China;;Effect of different tidal volume ventilation on rat bronchial and alveolar epithelial cell apoptosis[J];Journal of First Military Medical University;2005-05
2 GU Yan-mei, Wang Jian-rong(Postgraduate Department,Military Postgraduate Medical College, Beijing 100853, China);High Frequency Oscillation Ventilation and Airway Mucociliary Clearance[J];Nursing Journal of Chinese People's Liberation Army;2001-05
3 LEI Lian-hui,WEI Zhong-yu,YU Sen-yang,WANG Yu-gui,CHENG Rui,YANG Yang,ZANG Yun-jin.Intensive Care Unit,General Hospital of Armed Police Forces.Beijing,100039,China;Effects of high dose ambroxol on acute lung injury after liver transplantation[J];Chinese Journal of Respiratory and Critical Care Medicine;2008-05
4 ZHAO Shuangping , GUO Qulian, AI Yuhang, WANG Ruike, WANG E, HE Min. Department of Anesthesiology , Xiangya Hospital , Central South University, Changsha 410008, Hunan, China;Prophylactic effect of ambroxol on acute hydrochloric acid aspirationinduced lung injury[J];Chinese Critical Care Medicine;2005-06
5 YUAN Rong, ZHANG Yi-qiu, XIANG Zhi (Department of Geriatic, the First Hospital of Huaihua, Huaihua, Hunan 418000, P.R.China);Clinical curative effect observation of large dose Mucosolvan in AECOPD[J];China Journal of Modern Medicine;2008-16
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 CUI Hujun 1△ , ZHANG Mingli 1, XIAO Feng 1, LI Yan 1,WANG Jin 1, CHEN Hongyi 2 (1. Department of Cardiac surgery, 2. Department of Thoracic surgery, Peking University First Hospital, Beijing 100034, China);Comparison and correlative analysis of pulmonary function markers after extracorporeal circulation[J];Journal of Beijing Medical University;2003-02
2 WU Hong-tao,MA Xiao-lin,JIANG Yao-guang (Trauma Center,Institute of Surgery Research,Daping Hospital,Third Military Medical University, Chongqing 400042,China);Study of mucosolvan treatment of traumatic ALI in rabbits[J];Journal of Traumatic Surgery;2005-01
3 DENG You-hua,GUO Zheng-heng,CHEN Hong-ming,et al.Department of Cardiothoracic Surgery, YouJiang National Medical College,Baise,533000,China;Impacts of Anisodamine(654-2) Combined with Exogenous Pulmonary Surfactant on Tomor Necrosis Factor (TNF-α),Structure Changes of Lung Tissue During Pig's Lung Ischemic-reperfusion Injury[J];Journal of Chinese Physician;2002-04
4 ZHENG Yan-hui,KUAN Shou-jing.Department of Pediatvics The 3rd Xiang Hospital,Central South University,Changsha,410013,China;Effect of Small and Large Ambroxol on Pulmonary Surfactant in Asthma Guinea-pig[J];Journal of Chinese Physician;2003-S1
5 DENG Lin 2, FANG Feng 1, FANG Chao Ping 1, WU Yong Zheng 1 (1. Department of Pediatrics, Changhai Hospital, Second Military Medical University, Shanghai 200433, China; 2. Department of Pediatrics, the First People′s Hospital of Yichang, Yichan;Effects of ambroxol on pulmonary surfactant system ultrastructure in asthma guinea pigs[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;2000-02
6 LI Qi, QIAN Gui sheng, ZHANG Qing, WANG Chang zheng (Institute of Respiratory Diseases, Xingqiao Hospital, Third Military Medical University, Chongqing 400037, China);Effects of different doses of lipopolysaccharide on acute lung injury in rats[J];Acta Academiae Medicinae Militaris Tertiae;2004-10
7 TANG Beibei,YANG Guocheng,XIA Laju,MENG Xiangping,LIU Li,GAO XinghuaDept.of Biochemistry and Molecular Biology,School of Medicine,Wuhan University, Wuhan 430071,China;Effects of GM1 on Heme Oxygenase-1 Expression in PC12 Cells During Oxygen Glucose Deprivation and the Role of Phosphatidylinositol 3-kinase/Akt Pathway in the Course[J];Medical Journal of Wuhan University;2006-05
8 NIE Lei, LIU Yi-qi, YANG Jin-song(Department of Cardiothoracic Surgery,The Peoele’s Hospital of Hunan, Changsha 410005);Impact of Infusing Ambroxol Before Cardiopulmonary Bypass upon Lung Injury[J];Journal of Clinical Research;2006-10
9 SUN Yan-ling, ZHAO Jing-min, WANG Song-shan et al. 302 Hospital of PLA, Beijing 100039, China;Study of cellular apoptosis and its mechanism in lung and other organs of patients with severe acute respiratory syndrome[J];Medical Journal of Chinese People's Liberation Army;2004-02
10 JIANG Jinjun,BAI Chunxue,WANG Ling,et al.Department of Respiratory Medicine,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Effects of ECMO on plasma cytokines in dogs with acute lung injury[J];Journal of Emergency Medicine;2004-05
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