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《Journal of Central South University(Medical Sciences)》 2006-01
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Effects of aminoguanidine on the lung injury induced by the total hepatic ischemia-reperfusion in rats

CAO De-quan~(1,*),CHEN Yan-ping~(1),CHANG Ye-tian~(1),LI Yong-guo~(2)(1.Department of Anesthesiology;2.Department of General Surgery,Second Xiangya Hospital,Central South University,Changsha 410011,China)  
Objective To investigate the effects of aminoguanidine on the lung injury induced by the total hepatic ischemia-reperfusion in rats.Methods The total hepatic ischemia-reperfusion model was built after blocking of the hepatic porta,suprahepatic and infrahepatic vena cava.Ninety Sprague-Dawley rats were assigned randomly into 3 groups: Sham operation group(Group A,n=30);total hepatic ischemia group(Group B,n=30);and aminoguanidine treatment group(Group C,n=30).Each group was subdivided randomly into 3 subgroups(n=10) according to different time phases: 20 minutes after the total hepatic vascular exclusion(T_(0)),4hours after the reperfusion(T_(1)),and 48 hours after the survival.Group A and Group B were intravenously injected with normal saline(1mL/kg) while Group C was injected with aminoguanidine(20mg/kg) dissolved in normal saline(1mL/kg) 10 minutes before the open of the abdomin.The levels of portal blood nitric oxide(NO),endotoxin(ET),tumor necrosis factor-α(TNF-α) at T_(0) and T_(1) were detected;48 hours survival rates and the lung wet/dry weight ratio were counted;and the histological changes of the lung tissues were observed.Results Compared with Group A,the levels of portal vein NO,ET,and TNF-α at T_(0) and T_(1) in Group B and Group C were significantly higher(P0.05 or P0.01).But those indexes of Group C were lower than those of Group B(P(0.05).) The 48-hour survival rate in Group C was higher than that in Group B((P)(0.05).) The lung wet/dry weight ratio in Group C was lower than in Group B(P(0.05)) and the histological change of Group C was slighter than that in Group B.Conclusion Aminoguanidine has the protective effects on the lungs against the total hepatic ischemia-reperfusion induced injury.
【CateGory Index】: R657.3
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