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《Journal of Central South University(Medical Sciences)》 2006-02
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Effect of polygonum multiflorum thunb on BDNF expression in rat hippocampus induced by amyloid beta-protein(Aβ) 1-40

QIU Guang,WU Xiao-qiong,LUO Xue-gang~*(Department of Anatomy and Neurobiology,Xiangya School of Medicine,Central South University,Changsha 410013,China  
Objective To explore the effect of polygonum multiflorum thunb(PMT) on the expression of brain-drived neurtrophic factor(BDNF) in hippocampus CA1 in rats induced by Aβ1-40.Methods The rat model was established by injecting Aβ1-40 into the right dorsal hippocampus in rats,and their behavior was observed by Ymaze.The morphological changes of rat hippocampus were examined by the Nissl staining.The expression of BDNF in hippocampus CA1 neurons was also examined by immunohistochemistry and Western blot.Results After the administration of Aβ1-40,the times of rats learning how to elude electric stimulation were significantly increased,and the expression of BDNF in hippocampus CA1 were obviously reduced.The aggregation of Aβ1-40 in hippocampus and the morphological changes of CA1 hippocampus were found.After the treatment with PMT for 30 days,the times learning how to elude electric stimulation were obviously reduced,while the expression of BDNF in hippocampus CA1 was also increased.Conclusion PMT can reverse the down-regulation of BDNF expression in hippocampus CA1 induced by Aβ1-40.
【Fund】: 教育部科学技术研究重大课题(104141)
【CateGory Index】: R285
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Chinese Journal Full-text Database 5 Hits
1 Lan Zhang,Lin Li,Ya Li Li,Department of Pharmacology,Xuanwu Hospital,Capital University of Medical Sciences,Beijing Brain Aging Research Laboratory,Beijing 100053,China;Mechanism of the protection of stilbene glycoside which is the effective component of tuber fleeceflower root on nerve cells[J];Chinese Journal of Clinical Rehabilitation;2004-01
2 HU Ya-Er,SUN Qi-Xiang,XIA Zong-Qin (The Research Laboratory of Cell Regulation,Shanghai Second Medical University,Shanghai 200025);The effect of ZMS, an active component of Zhimu, on NGF and BDNF in brains of aged rats[J];Chinese Pharmacological Bulletin;2003-02
3 Zhang Shining, Chen Ming, Xiao Hong et al Nanjing Medical University Brain Hospital, Nanjing 210029;The research of rats' Alzheimer disease(AD) model induced by β-amyloid peptides(β-AP)[J];CHINESE JOURNAL OF GERONTOLOGY;1999-06
4 ZHANG Lan,LI Lin,LI Bin,FENG Yan,YIE Cui\|fei,ZHANG Li. Department of Pharmacology,Xuan Wu Hospital of Capital University of Medical Sciences,Beijing Key Laboratory for Brain Aging,Beijing 100053 [;Effect of Chinese compound 962 capsule on expression of nerve growth factor and Trk A receptor in hippocampus of aged rats[J];Chinese Journal of Natural Medicine;2000-04
5 Li Min, Du Xiaoping, Yang Qidong, et al. Department of Neurology, Xiang Ya Hospital, Xiang Ya Medical College, Central South University, Changsha 410008;The protection of polygonum multiflorum thunb to the rats'cerebral AChE neurons damaged by Kainic acid[J];Srtoke and Nervous Diseases;2002-05
Chinese Journal Full-text Database 10 Hits
1 AN Lan - min1, YANG Jun1,XU Bing2(1.Health and anti-epidemic station of Shijiazhuang, Shijiazhuang, 050011 China; 2.Hebei Medical University,shijiazhuang 050011, China);STUDIES ON THE APOPTOSIS AND THE EXPRESSION OF p53 BY LEAD IN RAT BRAIN[J];Carcinogenesis,Teratogenesis and Mutagenesis;2003-04
2 AN Lan-min1 ,NIU Yu-jie2 ,XU Bing2,LIU Na1 (1. Health and Anti-epidemic Station of Shijiazhuang,Shiijazhuang,050011,Hebei,china;2.Hebei Medical University,Shiiazhuang,050011 Hebei,China);Influence of Lead on the Apoptosis and the Expression of fos,jun,p53 and Nitric Oxide Synthase in Rat Brain[J];Carcinogenesis,Teratogenesis & Mutagenesis;2006-05
4 ZHU Qing feng tutor:XU Guan sun, SONG Xiao ge (Institute of Acupuncture & Meridians, Anhui College of Traditional Chinese Medicine, Anhui Hefei 230038,China);EFFECT OF ELECTRO ACUPUNCTURE ON MOTILIN LEVEL IN BRAIN AND BLOOD OF MORPHINE WITHDRAWAL RATS[J];Journal of Anhui Traditional Chinese Medical College;2002-01
5 HE Feng Tutor:YANG Jun, XU Guan sun, SHEN De kai (Second Clinic Department, Anhui College of Traditional Chinese Medicine, Anhui Hefei 230038, China);INFLUENCE OF ELECTROACUPUNCTURE ON LEARNING AND MEMORY FUNCTION AND CEREBRAL BLOOD FLOW IN VASCULAR DEMENTIA RATS[J];Journal of Anhui Traditional Chinese Medical College;2002-03
6 YIN Wei-ping 1, JIANG Ying 1, JIANG Ju-xiang 2, WANG Wei-ping 2 (1 Medical College, Suzhou University, Suzhou,215007; 2 College of Life Science, Suzhou University);Changes of Free Amino Acid Levels in Different Brain Regions of Aging Rats[J];Amino Acids & Biotic Resources;2001-04
7 WANG Wei-ping,JIANG Ju-xiang,JIANG Ying,XU Ying (Department of Biochemistry,Suzhou University,Suzhou 215007);Analysis of Polyamine Level in Certain Brain Regions of Aging Rats[J];Amino Acids & Biotic Resources;2002-01
8 WANG Bing-gao, YUAN Xin-yan, WANG Shou-biao, et al (Department of Breast Surgery, The Second Affiliated Hospital of Qingdao University Medical College, Qingdao 266042, China);;AN IMPROVEMENT OF THE MODEL OF FOCAL CEREBRAL ISCHEMIA AND REPERFUSION WITH LINE OCCLUSSION IN RATS[J];Acta Acadimae Qingdao Umvesitatis;2005-01
9 Guo Hui, Chi Huanfang, Wang Shoubiao, et al Department of Anatomy, Qingdao Medical College, Qingdao 266021;OBSERVATION OF NERVE FIBER CONNECTIONS BETWEEN LOCUS COERULEUS AND DORSAL COLUMN NUCLEI IN RATS[J];;1997-01
10 HUANG Hua HE Hai Yan HUANG Yi hua YU Hui WEI Wei SUN Jiu Rong (College of Life Science, Peking University, Beijing 100871, China);Influence of transsection of fimbria-fornix on the recovery of locomotive equilibrium ability after traumatic brain injury in rats[J];Acta Zoologica Sinica;2003-02
China Proceedings of conference Full-text Database 1 Hits
1 Huang Lili Li Tingli Guo Lengqiu Sun Chunyu (Heilongjiang University of Traditional Chinese Medicine,Harbin 150040);The effects of Schisandra Fruit on the sleep of freely moving rats[A];[C];2007
Chinese Journal Full-text Database 10 Hits
1 Han Mingxiang et al;Primary Research of Model "Dificiency-Blood Stasis-Senility[J];Journal of Anhui Traditional Chinese Medical College;1992-03
2 PAN Xiao-hui, LUO Wen-qian(The Chemistry & Life Science Department,Ankang Teachers College,Ankang 725000,China);The Studies on Chemical Constituents from the Root of Polgonum Cuspidatum in Ankang[J];Journal of Ankang Teachers College;2003-01
3 Chen Wansheng,Fan Wei,Yang Genjin,Qiao Chuanzhuo,Chen Haisheng,Yuan Yuan(Department of Pharmacognosy, College of Pharmacy,Second Military Medical University,Shanghai, 200433);Studies on the chemical constituents of Radix Polygoni multiflori Preparata[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;1999-07
4 CHEN Jian-hong,DU Jian(Fujian College of Traditional Chinese Medicine,Fuzhou,Fujian 350108,China);Clinical Study of Senile Dementia Treated by the Method of Tonifying Qi and Detoxication[J];Journal of Fujian College of Traditional Chinese Medicine;2006-05
5 ZHENG Li-ying ,WEIYan-ming1,CHEN Long2 1 (1. Collage of AnimalMedicine,Gansu Agriculture University,Gansu, Lanzhou 730070; 2. Lanzhou Branch of Ningxia Xiasheng Industry Group Co. Ltd,Gansu, Lanzhou 730000, China);Extraction of effective component from Radix astragli with cellulase[J];Journal of Gansu Agricultural University;2005-01
7 LI Yuan-bo,YIN Hui-an,ZHOU Yan-xia,TANG Ming-lin,AN Lian-ying(Depart.of Chemical Engineering and Pharmaceutics,Chengdu University of Technology,Chengdu 610059,China);The Method for Extraction of Curcumin in Curcuma Aromatica with Cellulose Enzymolysis[J];Guangzhou Chemistry;2004-03
8 SUN Wen-hong~1,DING Xiao-fei~2, GUO Li-ping~1, CAI ying~2, YU Duo~2, NI Xiao-hu~1 (1. School of Pharmaceutical Science, Harbin University of Commerce, Harbin 150076, China; 2. Shenyang Pharmaceutical University, Shenyang 110015, China);Study on ligustrazine effect on learning and memory of rats[J];Journal of Harbin University of Commerce(Sciences Edition);2004-01
9 LI Min, DU Xiao-ping, YE Hui, et al. ( Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.);Protective effect of polygonum multiflorum thunb on the cerebral cholinergic neurofibers in rats[J];Bulletin of Hunan Medical University;2003-04
10 LUO Li, HUANG Yi-ming~ (Deparment of Nutrition and Food Hygiene, School of Public Health, Central South University, Changsha 410078,China);Effect of resveratrol on the cognitive ability of Alzheimer’s mice[J];Journal of Central South University(Medical Sciences);2006-04
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Lu Yunru , Deng Qiaohong , Che Qiufang , et al. (College of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029);Quantitative Determination of 2,3,5,4' Tetrahydroxy stilbene-2-O-β-D glucoside in Polygonum Multiflorum and Its Preparation[J];JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;1998-06
2 MIAO Jian Ting, LI Zhu Yi , LIN Hong,et al.Center of Neurology, Tangdu Hospital,Fourth Military Medical University,Xi'an 710038,China;Ultrastructural changes of focal neurons after amyloid-beta protein injected into meynert nucleus in rat[J];Modern Rehabilitation;2002-03
3 TANG Hui dong, CHEN Xue hua, CHEN Sheng di.Rui jin Hospital, Shanghai Second Medical University, Shanghai 200025,China;Effects of nerve growth factor on Aβ_(25. 35) induced hippocampal neuron injury[J];Modern Rehabilitation;2002-13
4 Heng-Bing Zu,Department of Neurology,Jinshan Ho spital,Fudan Univer-sity,Shanghai 200540,China Sheng-Di Chen 1 ,Liang Liang 2 ,Jie-Yi Xu 2 ,1 Department of Neurology,2 Laboratory of Clinical Neurology,R uijing Hospital,Shanghai Second Me di-cal University,Shanghai 200540,China;Significance of IL-1αand S100βexpression induced by Amyloid-βprotein 40 in the pathogenesis of Alz heimer's disease[J];Chinese Journal of Clinical Rehabilitation;2003-28
5 CHEN Wan sheng, LIU Wen yong, YANG Geng jin, ZHANG Wei dong, CHU Zhi yong, CHEN Hai sheng, QIAO Chuan zhuo (College of Pharmacy, Second Military Medical University, Shanghai 200433, China);STRUCTURAL ELUCIDATION OF A NEW TETRAHYDROXYSTILBENE OF RADIX POLYGONI MULTIFLORI PREPARATA AND STUDY ON ITS CARDIOVASCULAR ACTIVITY[J];Acta Pharmaceutica Sinica;2000-12
6 Hu Yaer; Yi Ningyu; He Luming; et al. (Research Laboratory of Cell Regulation, Shanghai Second Medical University, Shanghai 200025);An autoradiographic study on the regional distribution of brain M-cholinergic receptors in aged rats[J];CHINESE JOURNAL OF CERIATRICS;1996-02
7 Cheng Guansheng; Liu Li; Peng Peiguo. (Department of Nuclear Medicine, Hunan Medical University, Changsha 410078);Retardation of age-associated loss of striatal dopaminergic receptor D_2 with Polygonum multiflorum Thunb in rats[J];CHINESE JOURNAL OF CERIATRICS;1996-02
8 XU Bin *, CHEN Junpao, ZHOU Guangdou, et al. * Department of Neurology, Zhujiang Hospital, the First Military Medical University, Guangzhou 510282, China;Effects of pinealectomy on the learning and memory abilities and cholinergic fibers in cerebral cortex of rats[J];CHINESE JOURNAL OF NEUROLOGY;2000-03
9 Zhang Lan,Li Lin,Li Bin, et al.Department of Pharmacology, Beijing Key Laboratory for Brain Aging,Xuan-wu Hospital of Capital University of Medical Sciences, 100053 Beijing,China;Effects of Sheng-wu Capsule on learning-memory ability and hippocampal histology in aged rats[J];Chinese Journal of Rehabilitation Theory & Practice;2002-09
10 Xu Jianzhong; Lu Min; He Zhijian; Yi Ningyu(Research Centre of Traditional Chinese Medicine,Shanghai Second Medical University, Shanghai 200025);The effect of ZMS(a sapogenine of Anemarrhena asphodeloides Bge. )on the learning ability and memory of aged rats[J];PHARMACOLOGY AND CLINICS OF CHINESE MATERIA MEDICA;1995-03
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