Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Central South University(Medical Science)》 2010-09
Add to Favorite Get Latest Update

Effect of different concentrations of sevoflurane pretreatment on acute lung injury induced by endotoxin in rats

ZHAO Shuangping,WU Jiao,GUO Qulian,ZHANG Zhong,YE Zhi(Intensive Care Unit,Xiangya Hospital,Central South University,Changsha 410008,China)  
Objective To investigate the effect of 3 concentrations of sevoflurane pretreatment on acute lung injury induced by endotoxin in rats.Methods Thirty-six male SD rats were randomly divided into 6 groups:a control group(Group A),a sevoflurane group(Group B),a 3.6% sevoflurane pretreatment group(Group C),a 2.4% Sevoflurane pretreatment group(Group D),a 1.2% sevo sevoflurane pretreatment group(Group E),and lipopolysaccharide(Group F).The rats were killed 6 h after lipopolysaccharide(LPS) or saline injection.Histological examinations of the lung tissues were performed with light microscope.Lung wet/dry weight(W/D) ratio,myeloperoxidase(MPO) activity,and intercellular adhesion molecule-1(ICAM-1) mRNA expression were assayed.Results Introvenous LPS significantly aggravated lung tissue damage,increased lung W/D ratio,MPO activity,and lung ICAM-1 mRNA expression compared with the control group(P0.05).Precondition with 2.4% sevoflurane significantly attenuated the above-mentioned changes induced by LPS(P0.05).The 3.6% LPS(Group C) significantly attenuated lung tissue damage and decreased MPO activity,lung ICAM-1 mRNA expression compared with the Group F(P0.05),but no significant change in lung W/D ratio was seen(P0.05).MPO activity was significantly decreased in Group E(P0.05),but lung W/D ratio and lung ICAM-1 mRNA expression had no significant changes(P0.05).Conclusion Precondition with 2.4% sevoflurane can reduce LPS-induced lung injury in rats.Decreased expression of ICAM-1 and less accumulation of neutrophils were participated in its mechanism.
【Fund】: supported by the fund from the Department of Science and Technology of Hunan Province P.R. China (06SK3022)
【CateGory Index】: R965
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 5 Hits
1 CHANG Jia-song,WEI Kai-feng,XU De-guo(Nanjing University of Chinese Medicine,Nanjing 210029,Jiangsu,China);Effect of Shengjiang Powder on Expression of ICAM-1 of Lung Tissue Cells in Acute Lung Injury Rats[J];Journal of Liaoning University of Traditional Chinese Medicine;2008-01
2 SUN Yan-hong (?) Yong WANG Jun-ke Department of Anes(?)siology,Frist Affi(?) (?) of (?) Medical University,Shenyang 110001,China;Effects of sevoflurane on endotoxin-induced oxidative stress response of the lungs in rats[J];Chinese Journal of Anesthesiology;2006-08
3 SUN Yan hong,ZHANG Qian,WANG Jun ke,CUI Yong Department of Anesthesiology,First Affiliated Hospital of China Medical University,Shenyang 110001,China;Effects of sevoflurane on membrane permeability of alveolar capillaries in rats with acute lung injury caused by endotoxin[J];Chinese Journal of Surgery;2004-16
4 GU Da-yong,LIANG Bing,TANG Xu-dong,et al.Science Laboratory,Number 401 Hospital of PLA,Shandong Qingdao 266071,China. Clinical Experimental Institute,Chendu Army General Hospital of PLA,Sichuan Chendu 610083,China;A Research on Expression of ICAM-1 and Adhesion to PMN of PMVEC Directly-Induced by LPS[J];Journal of Chinese Microcirculation;2006-01
5 GUO Zhengming1,CHEN Yi2,LIU Huijun2,XIAO Yuequn1,SONG Haipeng1,WANG Zhaozhao1,QU Xiaolin1,LUO Ziqiang2(1.Department of Basic Science,Hunan Traditional Chinese Medicine College,Zhuzhou Hunan 412012;2.Department of Physiology,Xiangya School of Medicine,Central South University,Changsha 410078,China);Ginkgo biloba extract (Ginaton) attenuates acute lung injury induced by lipopolysaccharide in mice[J];International Journal of Pathology and Clinical Medicine;2009-04
Chinese Journal Full-text Database 10 Hits
1 SHANG GUAN Wang-ning LIU Jin Department of Anesthesiology,West China Hos-pital,SiChuan University,Chengdu 610041 ,China;The effects of inhaled anesthetics on lung[J];International Journal of Anesthesiology and Resuscitation;2007-04
2 Zhong Yi,Gao Qong,Ou Wei,et al.Department of Anesthesiology,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,China;Effects of sevoflurane preconditioning against cardiopulmonary bypass-induced oxidative stress response of lungs[J];Guizhou Medical Journal;2010-02
3 QU Ying(Department of Neurology,Chongqing Emergency Medical Center,Chongqing 400014,China);Research on treatment effects of Ginkgo Biloba Extract on chronic cerebral circulation insufficiency[J];Chongqing Medicine;2010-18
4 SHANGGUAN Wang-ning, XIANG Yong, LIU Jin. Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, China;The Effect of Pulmonary Static Inflation with Sevoflurane During Cardiopulmonary Bypass on Lung Function in Patients Undergoing Cardiac Valve Replacement Surgery[J];Journal of Sichuan University(Medical Science Edition);2008-05
5 FAN Lili,YU Xiangyou. Intensive Care Unit,the First Affiliated Hospital to Xinjiang Medical University,Urumqi 830054,China;Influence of ulinastatin on the concentration of cell adhesion molecules and the protective effect on lung injury in cardiopulmonary bypass[J];Journal of Chinese Practical Diagnosis and Therapy;2010-02
6 ZHENG Hong,Department of Anesthesiology,The People's Hospital if Yibin City,Yibin 644000,Sichuan,CHINA;Sevoflurane inhalation anesthesia combined with infraorbital nerve block in infant for cleft lip and palate repair surgery[J];Hainan Medical Journal;2010-05
7 CANG Jing, WANG Li-jun, XUE Zhang-gang(Department of Anesthesiology,Zhongshan Hospital,Fudan University,Shanghai 200032,China);Effects of combined sevoflurane-epidural anesthesia on inflammatory factors in rabbits with hypoxic lung injury[J];Fudan University Journal of Medical Sciences;2009-02
8 GUO Wei-ping1,2,TIAN Gai2.1 Department of Anesthesiology,The First Hospital of Yibin,Yibin Sichuan 644000,China;2 The Hospital Affilieated of Chengdu Medical College Hospital,Yibin Sichuan 644000,China;Application of sevoflurane combined with ketamine for intravenous anesthesia in children with oblique hernia surgery[J];Journal of Clinical and Experimental Medicine;2010-07
9 WANG Jun,et al.The First Affiliated Hospital of Wenzhou Medical College,Wenzhou,325000,China;Intercellular Adhesion Molecule-1 in Lung Injury of Cardiaopulmonary Bypass and the Protective Effect of Shenmai Injection[J];Zhejiang Journal of Integrated Traditional Chinese and Western Medicine;2009-03
10 YAO Shu-tong,ZHAO Xiu-mei,LIU Xiu-hua.Dept.of Pathophysiology,PLA General Hospital,Beijing 100853,China;ICAM-1 Inhibition Involving Small Intestinal Protection Induced by Ischemic Postconditioning in Rats[J];Journal of Chinese Microcirculation;2008-02
【Secondary Citations】
Chinese Journal Full-text Database 6 Hits
1 ;Effects of the Extract of Gingko Leaf Ginaton on Acute Lung Injury Caused by Lipopolysaccharide in Mice[J];Guiding Journal of TCM;2006-08
2 LI Qi 1, QIAN Gui-sheng 1, ZHANG Qing 1, TANG Zheng-cai 2, GAO Zheng-jin 2 (?1 ?Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China; ? 2?Respiratory Department of 324th Hospital, Chongqin;Changes of IL-10 mRNA expression and activator protein-1 activity in lung of rats with SIRS-acute lung injury induced by lipopolysaccharides[J];Chinese Journal of Pathophysiology;2002-08
3 Lei Wenzhang,etal.Department of furgery,First AffiliatedHospital,West China University of MedicalSciences,Chen dou 610041.;The relationship between the endotoxemiaand damages to multiple organs in the experimental necrotic pancreatitis[J];CHINESE JOURNAL OF EXPERIMENTAL SURGERY;1995-03
4 GUZhenyong ,LING Yiling,CONGBin ,etal DepartmentofPathophysiology,HebeiMedicalUniversity ,Shijiazhuang 0 5 0 0 17, China;Peroxynitrite mediated acute lung injury induced by lipopolysaccharides in rats[J];NATIONAL MEDICAL JOURNAL OF CHINA;2000-01
5 GU Da_yong,ZENG Xiang_yuan,CHEN Li,et al. Clinical Experintal Institute of Chendu Army General Hospital 610083, China;An Experimental Study on ICAM-1 Expression of Pulmonary Microvascular Endothelial Cells Induced by LPS and Its Mechanism Through Nuclear Factor-kappa B Pathway[J];Journal of Chinese Microcirculation;2002-01
6 ZHANG Qiujin  , SHEN Hong, ZHANG Wei, LI Yinping, LI Tanshi.  EmergencyDepartment, General Hospital of PLA, Beijing 100853, China;Effects of combined naloxone and methylprednisolone on nuclear factor-κB expression in the lung in acute lung injury in rats[J];Chinese Critical Care Medicine;2005-06
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved