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EFFECTS OF PERINDOPRIL ON HYPERTENSION, SERUM ANGIOTENSIN I CONVERTING ENZYME ACTIVITY AND URING LEVEL OF N ACETYL BETA D GLUCOSAMINIDASE

Wang Zhonglin Li Yifu Zhou Yuming (Department of Cardiology, The Second Affiliated Hospital, Hunan Medical University, Changsha 410008)  
Perindopril 4mg once daily was given to 40 hypertensives for 4 weeks. The results showed that systolic and diastolic blood presure were decreased by 3.2kPa (22.2±2.21~19.0±1.92kPa) and 1.87kPa (13.4±1.21~11.5±1.27kPa), respectively. The total effective rate was 80%. Serum Angiotensin I converting enzyme activity in 30 patients was significantly decreased from 58.5±29.5U to 18.2±16.2U (P0.01). The urine level of N acetyl beta D glucosaminidase (NAG) in 27 patients significantly decreased from a prior level of 13.66±7.81U·gCr -1 to 10.12±5.57U·gCr -1 (P0.01). The side effects of perindopril were cough (7.5%), constipation (10%), dizziness (7.5%), flatulence (7.5%) and diarrhea (5%). We conclude that perindopril is a potent antihypertensive drug with significant prevention on hypertension induced early renal damage.
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