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《BULLETIN OF HUNAN MEDICAL UNIVERSITY》 1997-04
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DETECTION OF p53 GENE MUTATIONS IN HUMAN GESTATIONAL TROPHOBLASTIC NEOPLASIA BY POLYMERASE CHAIN REACTION SINGLE STRAND CONFORMATIONAL POLYMORPHISM TECHNIQUES

Wu Yilin Zhang Qionying Tang hong (Department of Gynecology and Obstetrics, The Second Affiliated Hospital, Hunan Medical University, Changsha 410011)  
Using polymerase chain reaction single strand conformational polymorphism (PCR SSCP) and EB staining technique, paraffin embeded sections of 20 hydatidiform mole and 4 choriocarcinoma were detected in the exons 5 and 8 of p53 gene. The results showed that mutations of p53 gene were 0/9 in the normal chorionic villi, 6/20 (30%) in hydatidiform mole and 3/4 in choriocarcinoma. This study suggests that mutations of p53 gene may be an important event in human gestational trophoblastic neoplastigenesis and its progression.
【CateGory Index】: R446.61
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【Co-references】
Chinese Journal Full-text Database 10 Hits
1 WANG WEN-JUAN,WANG YAN-KUI,YANG LING,et al(Department of Obstetrics and Gynecology,The Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,China);ESTABLISHMENT OF CELL CLONE WITH STABLE EXPRESSION OF HPV16 E6 siRNA[J];Acta Academiae Medicinae Qingdao Universitatis;2007-04
2 ZHOU Jin1, CHEN Shi-ling1, XING Fu-qi1, PANG Zhan-jun1, LI Bing2, ZHOU Wen-qu2, FU Xin2, DING Yan-qing31Department of Obstetriscs and Gynecology, 3Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; 2Central Laboratory, Guangzhou Medical College, Guangzhou 510182, China;Association of the novel hydatidiform mole-related gene F10 with the invasiveness of trophoblastic tumor[J];Journal of First Military Medical University;2005-02
3 CUI Yan-guo, QUAN Song, XING Fu-qi Assisted Reproduction Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;F10 gene knock-down mediated by RNA interference induces apoptosis of KLE cells[J];Journal of Southern Medical University;2008-03
4 CUI Zhumei, YANG Xiuyu, XIANG Yang, et al (Peking Union Medical College Hospital, Beijing 100730, China);The reasons of misdiagnosis of postpartum choriocarcinoma[J];Chinese Journal of Clinical Obstetric and Gynecology;2001-01
5 Zhou Jin, Liang Weihua, Li Bing, et al. Obstetriscs and Gynecology , Nanfang Hospital, Nanfang Medical University, Guangzhou 510515;The expression of hydatidiform mole associated new gene F10 in different tumor tissues[J];Guangdong Medical Journal;2005-05
6 LI Gui-tang,PANG Zhan-jun,ZHOU Jin,et al.Department of Obstetrics and Gynecology,Nanfang Hospital,Nanfang Medical University,Guangzhou 510515,China;Cloning of new genes associated with the pathogenesis of hydatidiform mole[J];Guangdong Medical Journal;2006-01
7 CUI Yan-guo,QUAN Song,XING Fu-qi.Department of Assisted Reproduction Center,Nanfang Hospital,Nanfang Medical University,Guangzhou 510515,China;KLE cell apoptosis is Promoted By F10 RNAi Through Cytochrome C[J];Guangdong Medical Journal;2008-04
8 FU Xin~1,ZHOU Wen-qu~1,XING Fu-qi~2,LI Bing~(1*)(1.Experimental Medical Research Center,Guangzhou Medical College,Guangzhou 510182;2.Dept of Obstetrics and Gynecology,Nanfang Hospital,Southern Medical College,Guangzhou 510515);Construction and Subcellular Localization of F10-incorporating GFP Fusion Protein Vector[J];Academic Journal of Guangzhou Medical College;2005-05
9 NI Ya-li, LIU Zhen (The Hospital of Women and Children Health Care of Gansu Province, Lanzhou 730050, China);Expression and Its Clinical Significance of P_(53) in Pregnancy Trophoblast Tumor[J];Heilongjiang Medical Journal;2002-01
10 HE Qunli1),ZHAO Guoxin2),MIAO Liqun3),SUN Xiang1),WANG Yongling4),ZHANG Mingzhi5)1)Department of Microbiology,Xinxiang Medical College,Xinxiang 453003 2)Henan Institute of Medical Science,Zhengzhou 450052 3)Clinical Laboratory,the Second People's Hospital of Baoji,Baoji 721000 4)Department of Physiology,Xinxiang Medical College,Xinxiang 453003 5)Department of Oncology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052;Construction of siRNA vector targeting human Livin gene and observation of its silence efficiency[J];Journal of Zhengzhou University(Medical Sciences);2007-04
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 CAI Jufang ZHU Ye HUANG Minglong et al Department of ultrasound, Shajing People’s Hospital, Shenzhen, 518104, China;Color Doppler Transvaginal Scan in Evaluation of Uterine Hemodynamics in Gestational Trophoblastic Tumor[J];International Medicine & Health Guidance News;2007-10
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