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《Henan Journal of Preventive Medicine》 2010-04
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The Experimental Research of the PoisonousEffects of Cadmium on the Reproduction of Male Rats

GUO Shu-bang,LIU Li-qing,LU Tao-sheng,DAI Ai-ying,etc.Heze Medical College,Heze Shandong 274000,China.  
Objective To observe the poisonous effects of cadmium on the reproduction of male rats.Methods: To irrigate the stomach of male rats with 5,10,20 mg/mL chlorinating cadmium solution respectively and continuously for 14 days and kill half of the rats respectively on the 7th day and14th.Results Weight,testicular exponent,sperm numbers and testosterone contents have reduced from control group to cadmium-loaded group.On the 7th day,there was an obvious difference between the control group and the experimental group in terms of the weight,testicular exponent,sperm numbers(P0.05),and there was also a notable difference between the middle-cadmium group,the high-cadmium group and the control group(P0.01).In terms of testosterone contents,there was no obvious difference between the low-cadmium group and the control group while there was an obvious difference between the middle-cadmium group and the control group(P0.05)and a very notable difference between the high-cadmium group and the control group(P0.01).On the 14th day,there was an obvious difference between the low-cadmium,middle-cadmium group,the high-cadmium group and the control group in terms of the weight,testicular exponent,sperm numbers(P0.01).In terms of testosterone contents,there was an obvious difference between the low-cadmium group and the control group(P0.05)and there was a very obvious difference between the middle-cadmium group,the high-cadmium and the control group(P0.01).With the increasing load of cadmium load,the weight,testicular exponent,sperm numbers and testosterone contents of male rats have reduced obviously,which assumes a notable agent-effect relation.Conclusion The continuous 14-day irrigation of the stomach of male rats with chlorinating cadmium solution can produce obvious toxicity to reproductive system.
【CateGory Index】: R114
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