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《Journal of Hunan Normal University(Medical Sciences)》 2008-01
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Modulation Effect on Dislipidemia and Atherosclerosis by Atorvastatin in Newly Diagnosed Type 2 Diabetes Patients

YANG Teng-shun,SHAO Hui-ge,OUYANG Jun (The First Hospital of Changsha,Changsha,Hunan 410005,China)  
Objective To explore the modulation effect of Atorvastatin on dislipidemia and atherosclerosis in newly diagnosed type 2 diabetes patients.Methods 155 newly diagnosed type 2 diabetes patients were randomly to receive Atorvastatin therapy(40mg/d,n=80) and conventional treatment group(n=75);the mean follow-up period was 12 months.Results Under the same control of blood glucose and blood pressure,the serum levels of FBS,2h FBS,HbA1C,TC,TG,LDL-C,hs-CRP and Carotid intima-medial thickness(IMT) were significantly decreased in Atorvastatin therapy group.The correlation analysis revealed the decreased levels of TC,TG,LDL-C,hs-CRP and IMT were related to the Atorvastatin therapy.Conclusion Atorvastatin therapy is effective on modulating dislipidemia in newly diagnosed type 2 diabetes patients and is related to improve the arteriosclerosis and inflammatory reaction.
【CateGory Index】: R587.1;R543
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