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《Journal of Zhengzhou University(Science Medical)》 1984-03
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Studies on the chronic toxicity of bimolane (AT-1727)

Wang Qingduan, et al Pharmacologic Department, Henan Medical Institute  
Bimolane (AT-1727), bis[N-morpholinomethyl--Piperazinedine 1, 2-bis (3, 5-dioxopiperazinyl)-ethane], is a derivative of ICRF--154.Expe-riments showed that this compound was an effective antineoplastic agent.In view of long-term administration of this drug, its chronic toxicity onrats was studied. Experiments showed that no effect on weight, bone mar-row, liver and kidney functions was noted in the rats administered dailythrough the intragastric route for 9 months at the total dosege of 2,925mg/kg and 5,850mg/kg respectively. Histological examinations of the vitalorgans (such as heart, liver, lung, kidney, spleen, intestine and stomach)showed no definite pathological changes.
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1 Zhang Tanmu,Chen Zhengyu and Linchen(Department of Pharmacoogy Henan Medical Institute,Zhengzhou);PHARMACOLOGICAL STUDIES ON BIMOLANE(AT-1727), A NEW ANTINEOPLASTIC AGENT[J];Acta Pharmaceutica Sinica;1980-10
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