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A preliminary study on the tolerance and physical dependence on brucine

Zhang Guohua;Zhu Yanna;Bao Mengzhou;Cao Yongshu Depertment of Pharmacology  
Daily ip brucine(24 mg/kg) 7 d in mice induced tolerance,as it was seen with morphine(25 mg/kg). When the combination of the two drugs (brucine 12 mg/kg, and morphine 7.5 mg/kg) was giv-en, the induced tolerance time was markedly put off. The mouse jumping test was used to evaluate thephysical dependence potential of the brucine and the influence of brucine on morphine physical depen-dence. The results showed that it was not easy for brucine to yield physical dependence, nor could it re-duce the influence on morphine physical dependence.
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