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Study on acute and long-term toxicity of crude flovone of pueraria lobata

Wang Qingduan;Jiang Jinhua;Sun Wenxin;Xia Wei (Henan Institute of Medical Sciences,Zhengzhou450052)  
Aim:To observe acute and long-term toxicity of crude flavone of pueraria lobata(CFPL)in mice and rats.Methods: The experiments were designed for determing LD_50 dose of CFPL in mice .LD50and 95% confidence limit were determined with simplify probit unit method.The test was designed to determine long-term toxic effects of CFPL at the dose of 2.50,1.66, 0.83g/(kg·d) ig for 90 days in rats.Results:The LD_50 was 5.97(5.46~6.48)g/kg when CFPL was given ip,and 10.11(9.41~10.81)g/kg when given ig.The results of long -term toxicity showed that during the whole experimental period,the general condition of rats were good;Leucocyte and body weight of animals in the groups of large and middle doses decreased a little and returned to normal 15 days after stopping treatment.No noticeable toxicity was found in the kidney and liver function test,histopathological examination, platelet and red cell and hemoglobin.Conclusion:The CFPL has no accumulated toxic effect in rats.
【CateGory Index】: R994.1
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