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《Journa of Henan Medical University》 2001-03
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Effects of Radix Astragali on CFU-GM in irradiated mice

ZOU Dan,SHEN Hong,QUAN Hongxun,HU Qunyuan Department of Histology and Embryology,Henan Medical College for Staff and Workers′,Zhengzhou 450003  
Aim:To study the effects of Radix Astragali on hemopoiesis and its mechanism.Methods:By using cell culture of hemopoietic progenitors in vitro and diffusion chamber implantation in vivo,we observed the effects of Radix Astrogali on colony forming unit granulocyte /macrophage(CFU GM).Results:In diffusion chambers in vivo,the number of CFU GM were(27 14±5 88)/(4×10 5BMC) and(26 38±4 90)/(4×10 5BMC) in the Radix Astragali pretreated or treated groups,respectively,which were significantly higher than that of irradiated control group( P 0 01),but there was no stimulation activity in vitro on irradiated mice.Conclusion:Radix Astragali can stimulate the proliferation and differentiation of the CFU GM in diffusion chambers in vivo and may protect bone marrow of irrdiated mice.
【Fund】: 河南省科技攻关基金资助项目! 95 12 0 0 5 0 0
【CateGory Index】: R285.5
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