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《Journa of Henan Medical University》 2002-04
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Effects of nimodipine on brain NO and NOS levels and behavioral science in Alzheimer disease rats

BAI Hao 1), CUI Jingbin 2), WANG Junping 2), ZHAO Weixing 2), QI Ying 2) 1)Department of Molecular Genetics, Medical College, Fudan University, Shanghai 200032 2)Department of Biochemistry, Basic Medical College, Zhengzhou University, Zhe  
Aim: To determine the effects of nimodipine on brain nitric oxide (NO) and nitric oxide synthase (NOS) levels and behavioral science in Alzheimer disease (AD) rats. Methods: A total of 30 rats were allocated into control group, AD model group and nimodipine group (10 in each group). By the technique of solid-location and microinjection, in AD model group and nimodipine group, IBO 1 μl(5 μg)was injected into bilateral basal nuclei of Meynert (nbM)of rats to set up AD animal model. In control group IBO was replaced by 0.1 mol/L PB (pH 7.4). Nimodipine group rats orally took Nimodipine 0.5 mg/kg while control group and AD model group orally took normal saline. This process lasted for 60 days, twice per day, each time 2 ml.Then learning and remembering abilities were tested by maze experiment and jumping table experiment. Then all rats were decapitated, and hippocampus and cerebral cortex were dissected respectively to examine the concentrations of NO and NOS. Results: Compared with control group, in AD model group rats, the learning and remembering abilities decreased significantly, and the contents of NO and NOS increased significantly; compared with AD model group, in nimodipine group the learning and remembering abilities increased and the contents of NO and NOS decreased significantly. Conclusion: Ruining bilateral nbM of rats by IBO can set up ideal AD animal model. Nimodipine could significantly improve the learning and remembering abilities and reduce the contents of NO and NOS in hippocampus and cerebral cortex of AD model rats.
【Fund】: 河南省科技攻关资助项目  0 0 1170 80 5
【CateGory Index】: R749.16
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