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《Journal of Zhengzhou University(Science Medical)》 2004-06
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Effect of hypoxic pretreatment on expression of hypoxic-inducible factor-1α in transient focal cerebral ischemia rats

DUAN Dongxiao 1), ZHANG Guihong 1),XING Yin 1), GAO Xiaoqun 2), RU Liqiang 2) 1)Department of Physiology, Medical College, Zhenzhou Universty,ZhengZhou 450052 2)Department of Neurobiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030  
Aim: To study the effect of hypoxic pretreatment on the expression of hypoxic inducecible factor-1α(HIF-1α)in cerebral ischemia/reperfusion rat. Methods: A total of 80 SD rats were divided into sham-operated group(10 rats), hypoxic pretreatment group(35 rats), and hypoxic pretreatment plus transient cerebral ischemia group(35 rats). The rats were pretreated with hypoxic condition for 12 h prior to a 3 h middle cerebral artery occlusion followed 2 h, 6 h, 12 h, 24 h,and 48 h reperfusion. Brain infract volume was measured by TTC staining, and the expression of HIF-1α was detected using immuohistochemistry. Results:Compared to transient cerebral ischemia group, infarction size in hypoxic pretreatment group descended (P0.05). Immunohistochemistry results showed that the expression of HIF-1α increased in transient cerebral ischemia rats after hypoxia pretreatment(P0.05). Conclusion: Hypoxic pretreatment plays an important role in cerebral protection of focal cerebral ischemia rats. One of the mechanisms of brain protection of hypoxic pretreatment may relate to the increase of the HIF-1α expression.
【Fund】: 河南省自然科学基金资助项目  0 4110 43 70 0
【CateGory Index】: R363
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Chinese Journal Full-text Database 4 Hits
1 LIU Ling-yun1, CHAI Xi-qing2, LI Qing-jun1, CHENG Gui-hua2 (1Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017, 2Faculty of Pharmacy, Hebei Chemical & Pharmaceutical Vocational Technology College, Shijiazhuang 050017, China);Effect of human hypoxia inducible factor-1α gene transfection on apoptosis of Aβ25-35 induced hippocampal neurons of primary culture[J];Acta Academiae Medicinae Militaris Tertiae;2007-07
2 Chu Weiwei,Wu Buqiang,Sha Huanchen,Wang Dianhua(Yunnan Pharmacological Laboratory of Natural Products,Kunming Medical College,Kunming 650031,China);The role of ischemic postconditioning on intestinal mucosa in rats with ischemia-reperfusion injury[J];Journal of Xi'an Jiaotong University(Medical Sciences);2007-02
3 SU An-ying,LI Ling,SHAN Tie-ying,CHAI Xi-qing(Hebei University of Engineering,Handan,056002,China);Abstrac Effect of adeno-associated virus vector harboring human hypoxia inducible factor-1α gene on apoptosis of hippocampal neurons of primary culture[J];Occupation and Health;2010-20
4 SU An-ying,SHAN Tie-ying,LI Ling,CHAI Xi-qing (Hebei Engineering University School of Medicine,Handan, 056002,China);Construction and Expression of the Eukaryotic Expression Vector for Human Hypoxia Inducible Factor 1α Gene[J];Occupation and Health;2010-21
Chinese Journal Full-text Database 10 Hits
1 Wang Ronghui 1) Liu Guihua 1) Hu Qi 2) Zhang Yimin 1);Effects of Hypoxic Training on LDH and MDH Activities of Skeletal Muscles in Rats[J];JOURNAL OF BEIJING UNIVERSITY OF PHYSICAL EDVCATION;1998-03
2 LIU Ming~1, ZHANG Guo-qing~1, MA Xian-ying~2 (1.Shandong Sports Training and Technology College, Jinan 250014, Shandong China; 2. Shandong Financial College, Jinan 250002, Shandong, China);Research on Oxygen-transport Ability of Swimmers as the Effect of Simulating Altitude Training[J];Journal of Beijing University of Physical Education;2004-06
3 YIN Wei-na, ZHANG Chuan-xin Department of P. E. Qufu Normal University,Qufu 273165; Sports-Science Department of Taishan University ,Tai'an 271000,China;The Development and Studying of Plateau Training[J];Journal of Beijing Teachers College of Physical Education;2005-03
4 ZHOU Wei, WU Sheng Mei, CHEN Hui Jin, et al. Department of Pediatrics, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China;Delayed Cell Death Following Hypoxic-Ischemic Injury in Neonatal Rats[J];CHINESE JOURNAL OF CONTEMPORARY PEDIATRICS;2000-04
5 WANG Li~1,WANG Su-xia~2,MEI Chang-lin~(2*)(1.Department of Nephrology,Shanghai General Hospital of Chinese People's Armed Police Forces,Shanghai 201103,China;2.Department of Nephrology,Changzheng Hospital,Second Military Medical University,Kidney Disease Research Institute of PLA,Shanghai 200003);Effect of HIF1α and HIF2α on human renal cell carcinoma and their mechanisms: an RNAi approach comparison[J];Academic Journal of Second Military Medical University;2006-06
6 SUN Xue-jun~*,PENG Zhao-yun,CHEN Xiao-ying,TAO Heng-yi(Department of Diving Medicine,Faculty of Navy Medicine,Second Military Medical University,Shanghai 200433,China);Reactive oxygen species in regulation of hypoxia-inducible factor[J];Academic Journal of Second Military Medical University;2006-06
7 LIU Yan, BAO Jin hua, LAI Huang wen, YANG Chuan hong, FENG Xiao dong, LI Jian jun (Department of Hyperbaric Oxygen, General Hospital of Guangzhou Command, Guangzhou 510010, China);Effect of hyperbaric oxygen on structure of hippocampus neurons in adult rats[J];ACTA ACADEMIAE MEDICINE MILITARIS TERTIAE;2000-07
8 MA Yan 1, SUN Yue-Fen 1, GAO Wei 1, ZHOU Chang-Man 2 1Department of Medicine, 2Experimental Center of Neural Biology, Beijing Military Medical College, Beijing 100071, China;Effect of bFGF on Bcl-2 expression in anoxia and reoxygenation injured cultured skeletomyocytes[J];Journal of The Fourth Military Medical University;2002-06
9 GAO Xiaoqun 1) , DUAN Dongxiao 2) , XING Ying 2) , RU Liqiang 1) 1)Department of Neurobiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030 2)Department of Physiology, Basic Medical College, Zhengzhou University, Zhengzhou 450052;Effects of hypoxic preconditioning on neural cells apoptosis and expression of Bcl-2, Bax in rat cerebral ischemia-reperfusion[J];Journal of Zhengzhou University(Science Medical);2004-05
10 Liu Shanrong, Liu Houqi, Xiang Zhenghua, Meng Lin (Department of Histology and Embryology, Second Millitary Medical University, Shanghai 200433);EXPRESSION OF APOPTOSIS-RELATED GENE BAX AND BCL-2 IN HIPPPOCAMPUS AFTER GLOBAL ISCHEMIA[J];CHINESE JOURNAL OF ANATOMY;1999-05
【Secondary References】
Chinese Journal Full-text Database 9 Hits
1 ZHOU Wei1,JIANG Zheng1,ZHANG Bin2,XIANG Ting-xiu1,HUANG Ai-long3,WANG Pi-long1(1Department of Gastroenterology,First Affiliated Hospital,2Department of Community Medicine,College of Public Health,3Institute of Viral Hepatitis,Chongqing Medical University,Chongqing 400016,China);RNA interference targeting hypoxia inducible factor-1α in BGC-823 cells inhibits cell proliferation and induces cell apoptosis[J];Acta Academiae Medicinae Militaris Tertiae;2009-02
2 LIU Ke-xuan,HUANG Wen-qi;Protective effects of preconditioning and postconditioning against the intestines I/R injury[J];China Continuing Medical Education;2010-04
3 Chu Weiwei1,Wu Buqiang2,Sha Huanchen3,Wang Dianhua4(1.Department of Pathology,Xi'an Medical College,Xi'an 710021;2.Department ofGeneral Surgery,the Affiliated Heping Hospital of Changzhi Medical College,Changzhi 046000;3.Department of Hepatobiliary Surgery,the First Affiliated Hospital,Medical School ofXi'an Jiaotong University,Xi'an 710061;4.Yunnan Pharmacological Laboratory ofNatural Products,Kunming Medical College,Kunming 650031,China);Effects of ischemic postconditioning on intestinal mucosa mitochondrion after ischemia-reperfusion injury in rat intestine[J];Journal of Xi'an Jiaotong University(Medical Sciences);2008-04
4 KONG Wei-na,AN Sheng-jun,CHAI Xi-qing(Hebei Chemical & Pharmaceutical College,Shijiazhuang 050026,China);The RAGE-Aβ interaction and its effects on pathogenesis of Alzheimers disease[J];Chinese Pharmacological Bulletin;2009-04
5 YAO Shu-tong,ZHAO Xiu-mei,LIU Xiu-hua.Dept.of Pathophysiology,PLA General Hospital,Beijing 100853,China;ICAM-1 Inhibition Involving Small Intestinal Protection Induced by Ischemic Postconditioning in Rats[J];Journal of Chinese Microcirculation;2008-02
6 LIU Ke-xuan1,LI Yi1,LI Yun-sheng1,LIU Jia-xin1,HUANG Wen-qi1,WU Wei-kang2 1Department of Anesthesiology,The First Affiliated Hospital,2Institute of Integrative traditional Chinese and Western Medicine,Sun Yat-sen University,Guangzhou 510080,China;Intestinal ischemic postconditioning attenuates acute lung injury induced by intestinal ischemia/reperfusion in rats[J];Chinese Journal of Pathophysiology;2009-09
7 SUN Yi-min1,KONG Wei-na1,LI Guang-zhi2,CHAI Xi-qing1(1.Hebei Chemical & Pharmaceutical Vocational Technology College,Shijiazhuang 050026,China;2.The First People' s Hospital of Zhangjiakou,Zhangjiakou Hebei 075000,China);High brain iron in etiology of Alzheimer's disease and therapeutic approaches[J];Chinese Pharmacological Bulletin;2010-06
8 Jie Lin,Zhong Zeng,Organ Transplantation Center,the First Affiliated Hospital of Kunming Medical College,Kunming 650032,Yunnan Province,China.;Advances in research on the protective mechanisms of ischemic postconditioning against hepatic ischemia-reperfusion injury[J];World Chinese Journal of Digestology;2010-17
9 ZHENG Qiao-fen,CAO Ding-rui,ZHAO Li,et al.Department of Anesthesiology,First Affiliated Hospital,Shanxi Medical University,Taiyuan 030001,China;Effects of Sufentanil post-conditioning on acute lung injury induced ischemia-reperfusion in rats[J];National Medical Frontiers of China;2010-20
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