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《Journal of Zhengzhou University(Science Medical)》 2004-06
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Effect of hypoxic pretreatment on expression of hypoxic-inducible factor-1α in transient focal cerebral ischemia rats

DUAN Dongxiao 1), ZHANG Guihong 1),XING Yin 1), GAO Xiaoqun 2), RU Liqiang 2) 1)Department of Physiology, Medical College, Zhenzhou Universty,ZhengZhou 450052 2)Department of Neurobiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030  
Aim: To study the effect of hypoxic pretreatment on the expression of hypoxic inducecible factor-1α(HIF-1α)in cerebral ischemia/reperfusion rat. Methods: A total of 80 SD rats were divided into sham-operated group(10 rats), hypoxic pretreatment group(35 rats), and hypoxic pretreatment plus transient cerebral ischemia group(35 rats). The rats were pretreated with hypoxic condition for 12 h prior to a 3 h middle cerebral artery occlusion followed 2 h, 6 h, 12 h, 24 h,and 48 h reperfusion. Brain infract volume was measured by TTC staining, and the expression of HIF-1α was detected using immuohistochemistry. Results:Compared to transient cerebral ischemia group, infarction size in hypoxic pretreatment group descended (P0.05). Immunohistochemistry results showed that the expression of HIF-1α increased in transient cerebral ischemia rats after hypoxia pretreatment(P0.05). Conclusion: Hypoxic pretreatment plays an important role in cerebral protection of focal cerebral ischemia rats. One of the mechanisms of brain protection of hypoxic pretreatment may relate to the increase of the HIF-1α expression.
【Fund】: 河南省自然科学基金资助项目  0 4110 43 70 0
【CateGory Index】: R363
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