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《Journal of Zhengzhou University(Science Medical)》 2005-05
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Changes of serum matrix metalloproteinase-9 in patients with acute coronary syndrome

LI Shengli 1),DANG Yuhua 2), QIU Chunguang 2) 1)Department of Cardiology, the First People's Hospital of Shangqiu City, Shangqiu 476000 2)Department of Cardiology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052  
Aim: To investigate whether the increasing level of serum matrix metalloproteinase-9(MMP-9) in patients with acute coronary syndrome(ACS) reflects inflammation states of the arteries and whether the concentration of serum MMP-9 can predict the severity of the disease. Methods: A total of 67 patients were selected as acute coronary syndrome (ACS) group, including 46 patients with unstable angina (UA,UA cases in ACS group were allocated into 2 subgroups according to TIMI risk score: 24 patients with score ≥3 and 22 patients with score ≤2.) and 21 patients with acute myocardial infarction (AMI);20 patients with stable angina (SA) and 20 healthy individuals were used as control. The venous blood samples were taken and the concentration of MMP-9 was detected using ELISA.The concentrations of MMP-9 in different groups were compared.The concentrations of MMP-9 in patients with different lesions were compared according to the coronary angiography results.Results: The concentrations of serum MMP-9 in patients with UA and AMI were higher than those in patients with SA and normal control(P0.01);in patients with UA,the concentrations of serum MMP-9 in those with TIMI risk score≥3 was significantly higher than those with the score≤2,and the concentration of serum MMP-9 was positively correlated with TIMI risk score(r= 0.722, P0.001). According to the results of coronary angiography, the concentration of MMP-9 in ACS patients with moderate and serious lesions was significantly higher than that in patients with mild lesion. There was positive correlation between MMP-9 and degree of vessel lesion (r=0.651, P0.001). Conclusion: Inflammation plays an important role in the pathogenesis and deterioration of ACS.MMP-9 can be regarded as a novel marker of inflammation;the level of MMP-9 is correlated with severity of ACS and can be regarded as an index of unstable plaque.
【CateGory Index】: R541.4
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