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《Journal of Zhengzhou University(Science Medical)》 2005-05
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Changes of serum matrix metalloproteinase-9 in patients with acute coronary syndrome

LI Shengli 1),DANG Yuhua 2), QIU Chunguang 2) 1)Department of Cardiology, the First People's Hospital of Shangqiu City, Shangqiu 476000 2)Department of Cardiology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052  
Aim: To investigate whether the increasing level of serum matrix metalloproteinase-9(MMP-9) in patients with acute coronary syndrome(ACS) reflects inflammation states of the arteries and whether the concentration of serum MMP-9 can predict the severity of the disease. Methods: A total of 67 patients were selected as acute coronary syndrome (ACS) group, including 46 patients with unstable angina (UA,UA cases in ACS group were allocated into 2 subgroups according to TIMI risk score: 24 patients with score ≥3 and 22 patients with score ≤2.) and 21 patients with acute myocardial infarction (AMI);20 patients with stable angina (SA) and 20 healthy individuals were used as control. The venous blood samples were taken and the concentration of MMP-9 was detected using ELISA.The concentrations of MMP-9 in different groups were compared.The concentrations of MMP-9 in patients with different lesions were compared according to the coronary angiography results.Results: The concentrations of serum MMP-9 in patients with UA and AMI were higher than those in patients with SA and normal control(P0.01);in patients with UA,the concentrations of serum MMP-9 in those with TIMI risk score≥3 was significantly higher than those with the score≤2,and the concentration of serum MMP-9 was positively correlated with TIMI risk score(r= 0.722, P0.001). According to the results of coronary angiography, the concentration of MMP-9 in ACS patients with moderate and serious lesions was significantly higher than that in patients with mild lesion. There was positive correlation between MMP-9 and degree of vessel lesion (r=0.651, P0.001). Conclusion: Inflammation plays an important role in the pathogenesis and deterioration of ACS.MMP-9 can be regarded as a novel marker of inflammation;the level of MMP-9 is correlated with severity of ACS and can be regarded as an index of unstable plaque.
【CateGory Index】: R541.4
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Chinese Journal Full-text Database 2 Hits
1 CHENG Yong1,LI Chao-wu1,TU Ming-yi1, NIE Hai-ling1,SHUAI Jie2 (1 Department of Neurology, No. 161 Hospital of PLA,Wuhan 430000;2 Department of Neurology,Xinqiao Hospital,Third Military Medical University,Chongqing 400037, China);Relationship between MMP-9 and different types of carotid plaque[J];Acta Academiae Medicinae Militaris Tertiae;2007-18
2 WANG Maojuan,YANG Xiaoqiong, DENG Shukai,WANG Rongli Department of Respiratory Diseases,the Affiliated Hospital, Luzhou Medical College,Luzhou 646000;Detection of matrix metalloproteinase-2, matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in serum and bronchoalveolar lavage fluid of community acquired pneumonia patients[J];Journal of Zhengzhou University(Medical Sciences);2010-06
Chinese Journal Full-text Database 10 Hits
1 Wang Yun,Wang Zhen,Kong Lingyue,et al Tenth People Hospital Affiliated to Tongji University,Shanghai(200072);Study on Acute Coronary Artery Syndrome TCM Signs Distribution Rule[J];Journal of Zhejiang Chinese Medical University;2011-02
2 WANG Shi-han,WANG Jie,LI Ji,XIONG Xing-jiang,HE Qing-yong (Guang,anmen Hospital of China Academy of Chinese Medical Sciences,Bejing 100053,China);Clinic and biological basis studies on treating CAD angina pectoris by the mode combining diseases with synromes[J];China Journal of Traditional Chinese Medicine and Pharmacy;2010-12
3 QI Qi-ge1,LI Yao-yang1,ZHANG Peng2,CHEN Jian-xin2,WANG Hu-ping1,BI Li-fu1,WANG Wei2(1The Affiliated Hospital of Inner Mongolia Medical College,Hohhot 010050,China;2Beijing University of Chinese Medicine,Beijing 100029,China);Correlation study between unstable angina with syndrome of blood stasis due to qi deficiency and physical and chemical indicators of serum[J];China Journal of Traditional Chinese Medicine and Pharmacy;2011-02
4 HUANG Shuwen LI Keqing WANG Lei et alDepartment of Cardiology,People's Hospital of Dezhou,Dezhou 253014;Percutaneous coronary intervention for treatment of unstable angina or non-ST-segment elevation myocardial infarction[J];Journal of Binzhou Medical College;2005-06
5 ZHANG Guihua LIU Weimin LIN Li The People's Hospital of Yangxin County 251800;The clinical investegation of high intensity astragalus injection on unstable angina pectoris[J];Journal of Binzhou Medical University;2010-05
6 ;Advance in Diagnosis and Management of Unstable Angina[J];China Comtemporary Medicine;2001-06
7 ;合贝爽治疗不稳定性心绞痛疗效观察[J];Contemporary Medicine;2010-32
8 LIN Xiu-fang,DONG Dan-dan,XIA Xiao-ming.Department of Cardiology,Zhongshan University Fifth Hospital,Guangdong(519000),China;Early diagnosis and prognostic value of a qualitative test for heart-type fatty acid-binding protein in patients with acute coronary syndrome(ACS)[J];Journal of Chinese Physician;2006-11
9 Yu Li-ping, Na Kai-xian, Yang Xin-chun,et al. (Heart center,Beijing Chaoyang Hospital Capital University of medical sciences,Beijing 100020,china);Features of Clinical and Coronary Angiograph in Female Diabetic Type - 2 Patients with Coronary Atherosclerotic Heart Disease[J];Chinese Journal of Medicinal Guide;2006-02
10 DONG Hong-mei~1,HUANG Lan~1,SONG Yao-ming~1,LI Ai-min~1,YU Xue-jun~1,GENG Zhao-hua~1,JIN Jun~1,QIN Jun~1,ZHAO Gang~1,ZHOU Xiao-bo~1,GAO Yun-hua~2,XIA Hong-mei~2(~1Cardiovascular Disease Research Center,~2Department of Ultrasonic Diagnosis,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China);Relationship between blood ox-LDL levels in coronary sinus and impaired endothelium-dependent vasodilation in patients with coronary artery disease[J];Acta Academiae Medicinae Militaris Tertiae;2006-18
China Proceedings of conference Full-text Database 2 Hits
1 JIA Zhen-hua,GAO Huai-lin,GU Chun-hua,et al.Research Room of Vascular Diseases of Hebei Yiling Pharmaceutical Research Institute,Shijiazhuang 050035,China;Research on common pathogenesis of vessel diseases of 3469 patients based on TCM syndrome distribution[A];[C];2010
2 JIA Zhen-hua,GAO Huai-lin,GU Chun-hua,et al.Research Room of Vascular Diseases of Hebei Yiling Pharmaceutical Research Institute,Shijiazhuang 050035,China;Research on common pathogenesis of vessel diseases of 3469 patients based on TCM syndrome distribution[A];[C];2011
Chinese Journal Full-text Database 7 Hits
1 ;Diagnostic and prognostic value of serum MMP-2 and MMP-9 level in acute coronary syndrome[J];Acta Academiae Medicinae Militaris Tertiae;2005-18
2 ZHAO Chang-lin,XIE Han-ping(Department of Ophthalmology,Southwest Hospital,Third Military Medical University,Chongqing 400038,China);Expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases in Mooren's ulcer cornea[J];Acta Academiae Medicinae Militaris Tertiae;2006-15
3 WANG Guang-Hui1, JIN Fa-Guang1, CHU Dong-Ling1, DUAN Li2 1Department of Respiratory Diseases, Tangdu Hospital, Xi'an 710038, China, 2Institute of Neurosciences, School of Basic Medicine, Fourth Military Medical University, Xi'an 710033, China;Expressions of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in airway remodeling of asthmatic guinea pigs[J];Journal of the Fourth Military Medical University;2006-14
4 GUO Ai-ling1,TIAN Pei-chao2,WANG Huai-li2,ZHUO Zhi-hong2,QIAO Xiao-hui2,CHEN Xiao-xin2(1.Department of Surgery;2.Department of Pediatrics,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China);Expression of Matrix Metalloproteinase 9 and Tissue Inhibitor of Metalloprteinase 1 in Rats with Infectious Brain Edema[J];Journal of Applied Clinical Pediatrics;2008-11
5 Kong Ying-jun, Shi Yu-zhi, Zhang Yi-mei, Huo Jian-min Department of Respiratory Medicine, First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China;Expressions of intercellular adhesion molecule and matrix metalloproteinase 2 in lung tissues of patients with chronic obstructive pulmonary diseases[J];Chinese Journal of Clinical Rehabilitation;2006-20
6 XIN Xiao-feng ZHAO Ming LI Zi-ling SONG Yong SHI Yi Department of Pulmonary Diseases,Nanjing General Hospital of Nanjing Command,PLA,Nanjing 210002,China;Metalloproteinase-9/tissue inhibitor of metalloproteinase-1 in induced sputum in patients with asthma and chronic obstructive pulmonary disease and their relationship to airway inflammation and airflow limitation[J];Chinese Journal of Tuberculosis and Respiratory Diseases;2007-03
7 DU Yue, CAI Xu xu, WU Yu bin, et al. Department of Pediatrics, The Second Affiliated Hospital of China Medical University, Shenyang 110004,China;Research on the changes of expression of MMP 2 and TIMP 2 in the neonatal rats lung tissue caused by LPS[J];Chinese Journal of Perinatal Medicine;2004-06
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 LI Jin-ping,CHENG Jun,TIAN Zhuo,HU Hou-yuan(Department of Cardiology,Southwest Hospital,Third Military Medical University,Chongqing 400038,China);Celastrol down-regulates expressions of MIF and MMP-9 in the aorta of ApoE gene knockout mice[J];Acta Academiae Medicinae Militaris Tertiae;2008-09
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