Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Zhengzhou University(Medical Sciences)》 2006-03
Add to Favorite Get Latest Update

Detection of telomere length in esophageal squamous cell carcinoma tissue

WEN Hongtao 1),ZHANG Lei 2),FAN Qingxia 2),ZHANG Yunhan 3),WU Hongxia 4) 1)Department of Gastroenterology, the First Affiliated Hospital, Zhengzhou University,Zhengzhou 450052 2)Department of Oncology, the First Affiliated Hospital, Zhengzhou University,Zhengzhou 450052 3)Henan Key Laboratory of Tumor Pathology; Department of Pathology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052 4)Department of Pharmacology, College of Basic Medical Sciences, Zhengzhou University,Zhengzhou 450052  
Aim: To detect the telomere length and investigate the relationship between telomere length and clinicopathological features in esophageal dysplasia and carcinoma. Methods:The telomere length in 38 cases of esophageal squamous cell carcinoma (ESCC), 15 cases of dysplasia tissue of the esophagus, and 12 cases of normal esophageal squamous epithelial tissue were determined by using Southern blot and chemiluminescence methods. Results: The telomere length of ESCCs, dysplasia tissue of the esophagus, and normal esophageal squamous epithelial tissue was 6.095±2.841, 7.847±1.908, and 9.833±2.140, respectively. There was significant difference among ESCCs, dysplasia tissue, and normal tissue in telomere length (P0.05).The telomere length had no correlation with age in normal esophageal squamous epithelial tissue (P0.05). There was no significant difference between moderate and severe dysplasia tissue of the esophagus in telomere length (P0.05). The telomere length had no correlation to other clinicopathological features (age,gender,general type,size,histological differentiation,oncogenesis,and lymphnode metastasis) in ESCCs(P0.05). Conclusion: The abnormal changes of telomere length is not only related to the development of ESCCs but also is an early event in ESCCs.
【Fund】: 河南省自然科学基金资助项目0311643649;; “十五”“211工程”重点学科建设基金资助项目教重办(2002)第2号
【CateGory Index】: R735.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 1 Hits
1 HE Xingxiang, WANG Jialong, WU Jieli, et al. Department of Gastroenterology, Tongji Hospital, Tongji Medical University, Wuhan 430030, China;Telomere, cellular DNA content and gastric mucosal carcinogenesis.[J];Chinese Journal of Digestion;2001-01
【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 LI Chang-yong, REN Fu(Institute of Anthropology, Jinzhou Medical College, Liaoning Jinzhou 121001 China);Telomeres and Telomerase: Implications for Aging and Age[J];Progress of Anatomical Sciences;2005-03
2 First author's address Department of Gastroenterology,the Second Affiliated Hospital of chongqing Medic al University,Chongqing 400010,China;Genetic alterations and pathway in gastrocarcinoma occurrence[J];Chinese Journal of Gastroenterology and Hepatology;2003-06
3 YANG Shiming, FANG Dianchun, LUO Yuanhui,et al. Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing, 400038;Analysis of telomeric restriction fragment in gastric cancer and its premalignant lesions[J];CHINESE JOURNAL OF DIGESTION;1999-05
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 ZHAO Bin,GE Jing-fang,LI Jun(School of Pharmacy,Anhui Medical University,Hefei 230032,China);Advances in studies on the anti-tumor mechanisms of camptothecin[J];Anhui Medical and Pharmaceutical Journal;2006-01
2 LIU Cheng-Xia1, ZHANG Shang-Zhong1, ZHANG Xiao-Wei2, GENG Xiu-Lan2, LI Tie-Jun2, HUANG Li-Hua2, WANG Bing2 1. Department of Digestive Disease, Qilu Hospital, Shandong University, Jinan, Shandong, 250012, P. R. China 2. Centra Laboratory, Jinan Institute of Medical Science, Jinan, Shandong, 250013, P. R. China;Inhibitory Effect of Sodium Butyrate on 1,2-Dimethylhydrazine-induced Tumorigenesis of Colorectal Cancer in Mice[J];Chinese Journal of Cancer;2005-08
3 HE Min1, JIANG Yu-Yan2, ZHU Miao1, WEI Xiao2, QIN Jian2, ZHANG Zhi-Yong2, LI Li3 1. Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, 530021, P. R. China 2. Department of Environmental Health, School of Public Hygiene, Guangxi Medical University, Nanning, Guangxi, 530021, P. R. China 3. Cancer Hospital of Guangxi Province, Nanning, Guangxi, 530021, P. R. China;Effects of 3'-Azido-deoxythymidine on Telomerase Activity and Protein Expression of Hepatocarcinoma Cell Line SMMC-7721[J];Chinese Journal of Cancer;2006-05
4 XU Wen Huai, JU Xiao Ming, LI Han (Department of Surgery, Peking University First Hospital, Beijing 100034, China);Telomerase activity in colorectal cancer tissues and normal mucosa and its clinical significance[J];Journal of Beijing Medical University;2001-01
5 ZHANG Huo-jun, TIAN Jian-ming~*, WANG Pei-jun, SHAO Cheng-wei, YANG Ji-jin, ZUO Chang-jing, SHENG Jing, HAO Qiang, YUAN Min (Department of Radiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China);Effects of intratumoral injection of telomerase inhibitor AZT on implanted liver cancer in rats[J];Academic Journal of Second Military Medical University;2005-10
6 ′GE Lu-lu, LIU Chao, CHEN Xiao-hui, et al. ~△ Guangzhou Institute of Criminal Science & Technology, Guangzhou 510030, China);Gender specific profiles of human telomere shortening during aging[J];Chinese Journal of Forensic Medicine;2004-06
7 GE Lu-lu 1 ,LIU Chao 1 ,TAO Li-yang 2 ,et al.(1.Guangzhou Institute of Criminal Science&Technology,Guangzhou510030,China;2.Department of Forensic Biology,Zhongshan Medical College,Zhongshan U - niversity,Guangzhou510089,China);Study on the dynamic changing profiles of telomeric restricted fragment length among sex balanced different age groups[J];Journal of Forensic Medicine;2003-04
8 SUN hong-wei, GAO cai-rong (School of Forensic Medicine, Shanxi Medical University, Taiyuan 030001,China);The Application of Telomere DNA in Age Estimation of Forensic Medicine[J];Journal of Forensic Medicine;2005-02
9 Fang Jie~1,Liu Shuman~2,Wu Jinglan~2,Zhang Qinxian~2(1.Department of Internal Medrcine,Huaxian People's Hospital,Huaxian 456400,China;2.Department of Histology and Embryology,College of Medicine,Zhengzhou University,Zhengzhou 450052,China);Alteration of Telomere Length in the Gastric Carcinoma[J];Journal of Basic and Clinical Oncology;2006-05
10 ;Study Progress in Effects of Chinese Crude Drugs on Telomerase[J];Guiding Journal of TCM;2006-10
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved