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《Journal of Zhengzhou University(Medical Sciences)》 2006-03
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Detection of telomere length in esophageal squamous cell carcinoma tissue

WEN Hongtao 1),ZHANG Lei 2),FAN Qingxia 2),ZHANG Yunhan 3),WU Hongxia 4) 1)Department of Gastroenterology, the First Affiliated Hospital, Zhengzhou University,Zhengzhou 450052 2)Department of Oncology, the First Affiliated Hospital, Zhengzhou University,Zhengzhou 450052 3)Henan Key Laboratory of Tumor Pathology; Department of Pathology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052 4)Department of Pharmacology, College of Basic Medical Sciences, Zhengzhou University,Zhengzhou 450052  
Aim: To detect the telomere length and investigate the relationship between telomere length and clinicopathological features in esophageal dysplasia and carcinoma. Methods:The telomere length in 38 cases of esophageal squamous cell carcinoma (ESCC), 15 cases of dysplasia tissue of the esophagus, and 12 cases of normal esophageal squamous epithelial tissue were determined by using Southern blot and chemiluminescence methods. Results: The telomere length of ESCCs, dysplasia tissue of the esophagus, and normal esophageal squamous epithelial tissue was 6.095±2.841, 7.847±1.908, and 9.833±2.140, respectively. There was significant difference among ESCCs, dysplasia tissue, and normal tissue in telomere length (P0.05).The telomere length had no correlation with age in normal esophageal squamous epithelial tissue (P0.05). There was no significant difference between moderate and severe dysplasia tissue of the esophagus in telomere length (P0.05). The telomere length had no correlation to other clinicopathological features (age,gender,general type,size,histological differentiation,oncogenesis,and lymphnode metastasis) in ESCCs(P0.05). Conclusion: The abnormal changes of telomere length is not only related to the development of ESCCs but also is an early event in ESCCs.
【Fund】: 河南省自然科学基金资助项目0311643649;; “十五”“211工程”重点学科建设基金资助项目教重办(2002)第2号
【CateGory Index】: R735.1
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