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《Journal of Zhengzhou University(Medical Sciences)》 2008-02
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Effects of soluble granule of Shengjing on spermatogenesis disturbance induced by cyclophosphamide in mice

XU Lei,WANG Rui,ZHANG Weixing,WU Yufeng Department of Urology,the First Affiliated Hospital,Zhengzhou University;Henan Provincial Open Key Laboratory of Clinical Medicine,Zhengzhou 450052  
Aim:To observe the effects of Chinese medicine soluble granule of Shengjing on spermatogenesis disturbance of mice.Methods:A total of 30 Kunming mice were randomly divided into 3 groups:control group,model group,and the Chinese medicine group. Spermatogenesis disturbance models were obtained by being intraperitoneally injected cyclophosphamide.In the Chinese medicine group,soluble granule of Shengjing was administered after the models were formed(16 g/(kg·d),15 d).Mice in model group and control group were gavaged with equivalent normal saline. Testis weight was measured, blood was collected and the follicle stimulating hormone (FSH),luteinizing hormone(LH), and testosterone(T) levels were measured by radioimmunoassay. The histologic changes of testis were observed by using microscopy.Results:There were no significant differences on FSH, LH, T levels, testis weight, and the number of sperm cells on the seminiferous tubules and the spermatozoon in the lumina of the seminiferous tubules in the Chinese medicine group compared with control group (P0.05), and there were significant differences on all index compared with model group (P0.05).Conclusion:The Chinese medicine soluble granule of Shengjing is effective for therapy of spermatogenesis disturbance.
【Fund】: 河南省自然科学基金资助项目511044600;; 河南省医学科技攻关基金资助项目20060037;; 郑州市科技攻关计划基金资助项目052SGYS33216
【CateGory Index】: R285
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