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《Journal of Zhengzhou University(Medical Sciences)》 2008-03
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Significance of combined detection of CK-19 mRNA and tumor markers in diagnosis of lung carcinoma

NIU Songtao1),SHEN Weixi2),ZHENG Tao2),FAN Qingxia1),ZHOU Zhigang1),ZHANG Yan1),JING Haiman1) 1)Department of Oncology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052 2)Department of Oncology,the People's Hospital of Shenzhen,Shenzhen 510082  
Aim:To evaluate the significance of combined detection of CK-19 mRNA,CEA,NSE,and CYFRA21-1 in clinical diagnosis of lung carcinoma.Methods:Based on RT-PCR,radio immunoassay and immunoradiometric assay,the expression levels of CK-19 mRNA,CEA,NSE and CYFRA21-1 of 64 case of lung carcinoma,40 case of benign pneumonopathy and 30 healthy participants were detected respectively;meantime we also examined the sensitivity,specificity,accuracy of combination detection.Results:The positive rate of CK-19 mRNA in peripheral blood and CEA,NSE,CYFRA21-1 in serum were significantly higher than those in benign pneumonopathy and healthy participants group.There was no statistical significance when positive rate of CK-19 mRNA was evaluated in different pathological types.The positive rate of CK-19 mRNA in stageⅠ+Ⅱ,Ⅲ,and Ⅳ had an increasing tendency,the positive rate of CYFRA21-1 was highest in squamous carcinoma(78.5%),positive rate of NSE was highest in small cell carcinoma(81.3%),and positive rate of CEA was highest in lung adenocarcinoma(79.2%).Sensitivity and accuracy of combination detection were 90.6% and 86.2%.Conclusion:The combined detection of CK-19 mRNA,and tumor markers CEA,NSE,CYFRA21-1 in peripheral blood of patients with lung carcinoma was helpful to make more exact diagnosis,in addition,it also provides an important basis to differentiate pathological types of lung carcinoma.
【CateGory Index】: R734.2
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