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《Journal of Zhengzhou University(Medical Sciences)》 2010-06
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Detection of matrix metalloproteinase-2, matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in serum and bronchoalveolar lavage fluid of community acquired pneumonia patients

WANG Maojuan,YANG Xiaoqiong, DENG Shukai,WANG Rongli Department of Respiratory Diseases,the Affiliated Hospital, Luzhou Medical College,Luzhou 646000  
Aim:To detect the levels of matrix metalloproteinase-2(MMP-2),MMP-9 and tissue inhibitor of metalloproteinase-1(TIMP-1) in bronchoalveolar lavage fluid(BALF) and serum of patients with community acquired pneumonia (CAP),and to evaluate their roles in the pathogenesis of CAP.Methods:Sixty patients with CAP and twenty-six normal control subjects took part in the study. Twenty patients were severe lung infection. Serum specimens were collected in patients and normal control subjects. BALF specimens were collected in twenty of the CAP patients and normal control subjects. MMP-2, MMP-9 and TIMP-1 in serum and BALF were determined using ELISA.Results:The levels of MMP-2, MMP-9 and TIMP-1 in the serum of the patients were higher than those of the control group(t was 4.874, 9.961 and 4.500, all P0.001).The levels of MMP-2 and MMP-9 in the BALF of the patients were higher than those of the control group(t was 4.513, 8.165, all P0.001). There was no difference in the level of TIMP-1 in the BALF between the patients and the control group(t=1.717, P=0.093).MMP-2 and MMP-9 in the serum of the severy patients were higher than the other patients (t=3.995 and 3.539, P=0.002 and 0.008). While there was no difference in the levels of TIMP-1 in the serum between the severe patients and the other CAP patients(t=0.759,P=0.080).MMP-9 in serum of the patients showed a positive relationship with the number of neutrophils in the venous blood(r=0.855,P0.001).Conclusion:MMP-2,MMP-9 and TIMP-1 take part in the pathogenesis of CAP. MMP-2 and MMP-9 levels in CAP are two sensitive markers for pulmonary damage. MMP-2 and MMP-9 levels are related to clinical severity of CAP.Neutrophils is the main source of MMP-9 in the serum of the CAP patients.
【Fund】: 泸州医学院基金资助项目泸医院科(2004)10号
【CateGory Index】: R563.1
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